Radiation Oncology | Oncolink

Oncolink Features

Find My Cancer Drug

Tipos de Cancer / Cáncer del Seno / Opciones Del Tratamiento /

Radiation

Radiation Therapy and Breast Reconstruction: Considerations and Timing When women are diagnosed with breast cancer, they are immediately faced with an overwhelming amount of information and a need to make important decisions regarding treatment. The most important thing that must be decided on with their team of oncologists is how to best treat the cancer and reduce their risk of a recurrence or spread. However,
Why I Chose Breast Oncology Carla Fisher, MD Like many others, my path into the field of oncology was not a direct one. After making the decision to enter medical school, I chose to pursue a career in surgery followed by a specialization in breast oncology. As I look back, each choice was made for different reasons at different times and ultimately I am so happy with the
DCIS: To radiate or not to radiate? Dear OncoLink "Ask The Experts," I have had the removal of a 1/2 centimeter, stage 0, DCIS (ductal carcinoma in situ) from my left breast. The second biopsy was clear of cancer in the surrounding area. Is radiation necessary, or can I take a chemo drug like tamoxifen for 5 years instead and be considered quite safe from a return of cancer? I am
Second Malignancies after Treatment of Early Stage Breast Cancer with Lumpectomy and Radiation or Mastectomy without Radiation Presenter: E. Obedian Affiliation: Yale University School of Medicine Summary:Multiple studies have demonstrated the clinical efficacy of breast conserving therapy (BCT) for early stage breast cancer. Despite decades of experience, however, there are limited data regarding the safety of this treatment, specificially the risk of second
Tamoxifen & Radiation at The Same Time? Question I will be getting radiation and also tamoxifen treatment following a lumpectomy T2N0. Is there a downside to concurrent treatment? Answer Kevin Fox, MD, Medical Oncologist at Penn , responds: There have been several studies that have looked at concurrent versus sequential radiation and tamoxifen in early stage breast cancer. There
Partial Breast Irradiation Versus Traditional Radiation Question Why do I have to come for radiation every day for weeks? I have heard about some radiation for breast cancer that is done in only 5 days- what is that and is it just as good? Answer Gary Freedman, MD, Radiation Oncologist at Penn , responds: The purpose of delivering radiation therapy in a relatively small dose once a day for about 6
Surgery and Radiotherapy for Breast Cancer: A Look at the Studies In December of 2005, the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) published the combined results of 78 clinical trials evaluating radiation therapy and surgery in breast cancer patients.The group has published updates of this data every 5 years, and this publication represents 15 years of follow-up. The paper is jam-packed with
BRCA1/BRCA2 Germline Mutations in Locally Recurrent Breast Cancer Patients After Lumpectomy and Radiation Therapy: Implications for Breast-Conserving Management in Patients With BRCA1/BRCA2 Mutation Reviewers: Li Liu, MD Source: Journal of Clinical Oncology, Volume 17, No 10:3017-3024, October 1999.BackgroundFor women with early stage breast cancer, lumpectomy followed by radiation therapy (LRT) has been an acceptable standard of care. Much effort has been made to identify a subgroup of patients who are at higher risk for ipsilateral breast
Second Malignancies after Treatment of Early-Stage Breast Cancer: Lumpectomy and Radiation Therapy Versus Mastectomy Reviewers: Li Liu, M.D Source: Journal of Clinical Oncology, Volume 18 (12), 2406-2412 (June) 2000Précis: Radiation for breast cancer is not associated with greater risk of second malignancy.IntroductionAlmost all types of cancer can be caused by exposure to ionizing radiation with exception of chronic lymphocytic leukemia. Recent studies
Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17 Authors: Fisher B, Dignam J, Wolmark N, Mamounas E, Costantino J, Poller W, Fisher ER, Wickerham DL, Deutsch M, Margolese R, Dimitrov N, Kavanah M. Source: J Clin Oncol. 1998 Feb; 16(2): 441-52 Background Intraductal carcinoma-in-situ of the breast, commonly referred to as DCIS, is a pathologic diagnosis that is occurring with increasing
Impact of Concurrent Versus Sequential Tamoxifen With Radiation Therapy in Early-Stage Breast Cancer Patients Undergoing Breast Conservation Treatment Source: J Clin Oncol. 2005 Jan 1;23(1):11-6. Authors: Harris EE, Christensen VJ, Hwang WT, Fox K, Solin LJ. Affiliation: University of Pennsylvania, Philadelphia, PA. Background The optimal sequencing of breast irradiation and adjuvant systemic therapy is controversial. A randomized trial evaluating the sequencing of radiation and cytotoxic
Long-Term Outcome after Breast-Conservation Treatment with Radiation for Mammographically Detected Ductal Carcinoma in Situ of the Breast Source: Cancer. Vol. 103, p. 1137-1146 (2005). Authors: Solin LJ, Fourquet A, Vicini FA, Taylor M, Olivotto IA, Haffty B, Strom EA, Pierce LJ, Marks LB, Bartelink H, McNeese MD, Jhingran A, Wai E, Bijker N, Campana F, Hwang WT. Affiliations: University of Pennsylvania, Philadelphia (LJS, WTH) and 9 other centers. Background The role of
Lumpectomy and Radiation Therapy for the Treatment of Intraductal Breast Cancer: Findings from National Surgical Adjuvant Breast and Bowel Project B-17 Reviewers: John Han-Chih Chang, MD and Kenneth Blank, MD Source: Journal of Clinical Oncology 1998; volume 16 (number 2): pages 441 - 452BackgroundWith the use of screening studies such as mammograms and ultrasounds along with self breast exams, there has been a trend towards an increased incidence of finding breast cancers that are not invasive
Breast Feeding During Radiation Therapy Dear OncoLink "Ask The Experts," Is it safe to breastfeed your child if you are receiving radiation for 6 weeks for a brain tumor? Neha Vapiwala , MD, Senior Editor of OncoLink and Chief Resident in the Department of Radiation Oncology at the Hospital of the University of Pennsylvania, responds:Yes, it is fine for a woman to breastfeed while
Timing of Radiation and Chemotherapy with Breast Cancer Dear OncoLink "Ask the Experts," In patients with node negative breast cancer undergoing radiation therapy after lumpectomy, what is the best timing for radiation therapy with respect to chemotherapy (such as eight 3 week cycles of CMF)? The optimal timing of radiation therapy and chemotherapy under such circumstances
Breast reconstruction after lumpectomy and radiation treatment Dear OncoLink "Ask the Experts," It has been a year since I received 25 radiation treatments for Stage II Breast Cancer. Though I had a lumpectomy, I would like to reconstruct the breast to make it look more symmetrical. The plastic surgeon feels that a standard breast lift should fix the problem, but I would like to use a submuscular
Radiation and Tamoxifen for DCIS Dear OncoLink "Ask The Experts," In August, I was diagnosed with ductal carcinoma in situ. I had a lumpectomy and am currently going through 38 days of radiation. Will the radiation make less the chances of it recurring? And would tamoxifen make a difference? I am currently 43 years old I have been told that I would not be a good
Tamoxifen and Radiation Therapy for Early Breast Cancer Dear OncoLink "Ask The Experts," I had a lumpectomy for a Grade 1 breast cancer of 12mm with lymph node clearance. I am now taking Tamoxifen and my surgeon and radiation oncologist are advising follow up radiotherapy, due to start within the next few weeks. My reading indicates this is probably beneficial. I would appreciate your
Breast feeding while receiving radiation to the pelvis Dear OncoLink "Ask The Experts," I am getting ready to take external radiation therapy to my pelvic region. Can I still breast feed my 5 month old? Christina S. Chu, MD, Assistant Professor of the Division of Gynecologic Oncology at the University of Pennsylvania Health System, responds: If the radiation is
Radiation after Mastectomy with Reconstruction Dear OncoLink "Ask The Experts," I had a left-sided mastectomy with immediate reconstruction and tissue expander. I had DCIS with invasion and had a sentinel lymph node biopsy, which came back with 2 positive nodes out of 11. I'm undergoing chemo with A/C and Taxol for a total of 8 treatments, and my oncologist recommended radiation when I'm
Breast reconstruction after radiation therapy Dear OncoLink "Ask The Experts," I had a mastectomy followed by chemotherapy and radiation therapy for my advanced breast cancer. I completed radiation 3 months ago and have healed fine. I would like to have reconstruction. My oncologist recommended waiting for 6 months total after radiation but did say that it's probably OK to go ahead now. I'd
Screening Mammography and Radiation Exposure Dear OncoLink "Ask The Experts," My mother was diagnosed with breast cancer at 44 years old. As a result of this, I have been having routine mammograms annually since age 30 (I am currently 37). Am I doing more harm than good by doing this in terms of the long-term radiation exposure? Thank you.Lawrence J. Solin, MD, FACR, Professor of Radiation
Risk of Heart & Lung Damage with Breast Radiation Dear OncoLink "Ask The Experts," What is the risk of damage to your heart or lung from radiation treatment for left breast DCIS? Terry Styles, MD, Assistant Professor of Radiation Oncology at the University of Pennsylvania, responds: After many years of radiotherapy and many types of cancer treated, it became obvious that radiation to the chest
Swimming and Exercise While on Radiation Therapy for Breast Cancer? Dear OncoLink "Ask The Experts," I am about to start radiation therapy for breast cancer. Can I swim during this time? I have heard conflicting reports about exercise during therapy. Linda McGrath Boyle PT, DPT CLT-LANA, Cancer Rehab Specialist and OncoLink Lymphedema Team Editor, responds:Your doctors, including the surgeon, medical oncologist,
Radiation Therapy for Hodgkin's Disease and Breast Cancer Dear OncoLink "Ask the Experts," Your article on the long-term effects of radiation failed to mention the connection between radiation therapy and breast cancer. There have been many articles including the Journal of the National Cancer Institute, Journal of the American Medical Association, New England Journal of Medicine and the
Preliminary Analysis of Radiotherapy Data from CALGB 9082: Variability of Treatment Fields for Local/Regional Breast Cancer and the Impact of High Dose Chemotherapy on the Ability to Deliver Radiation Therapy Presenter: Lawrence B. Marks, M.D. Affiliation: Duke University/CALGB/SWOG Summary:Positive contributions of radiotherapy (RT) and chemotherapy in patients with high-risk breast cancer are well documented, but the sequencing of these modalities and dosage of chemotherapy in such patients remains controversial. This offering examines the effect
Timescale of Evolution of Late Radiation Injury after Postoperative Radiotherapy of Breast Cancer Patients Presenter: Silvia Johansson Affiliation: Umea University Hospital, Sweden Summary:Most of the modern randomized trials in breast cancer document toxicity associated with treatment, but none document these toxicities over the scale of decades. These data are important because many women are diagnosed with breast cancer at a relatively young age,
Fatigue During Radiation Therapy of Patients with Breast Cancer Presenter: H. Geinitz Affiliation: Technical University Munich, Muenchen, Germany Background: The purpose of this study was to evaluate the course and the possible causes of fatigue during postoperative radiation therapy (RT) of patients with breast cancer. Materials and Methods: 41 patients with postoperative RT after breast
Preliminary Results Of A Randomized Study Of Tamoxifen +/- Breast Radiation In T1/2 N0 Disease In Women Over 50 Years Of Age Presenter: Anthony Fyles Affiliation: Princess Margaret Hospital, Toronto, ON, Canada Background: Breast radiation (RT) shows definitive reduction in local relapses, however, with moderal toxicity and without a survival benefit. In Tamoxifen (TAM) treated pts, majority have no relpase without RT. With RT, TAM further decreased rate of
Sequencing of Chemotherapy and Radiation Therapy for Patients with Early Stage Breast Cancer: Updated Results of a Prospective Randomized Trial Presenter: Bellon, JR Presenter's Affiliation: Harvard Medical School Type of Session: Plenary Background This study was designed to evaluate the optimal sequencing of radiation therapy and chemotherapy in early stage breast cancer patients treated initially with lumpectomy The initial report with 5 yrs of follow-up showed for patients at
Preliminary Results of a Randomized Study of Tamoxifen Alone or Tamoxifen and Breast Radiation in Women over 50 Years of Age with T1/2 N0 Disease Presenter: A. Fyles Presenter's Affiliation: Princess Margaret Hospital Type of Session: Scientific Background The standard of care for women with invasive breast cancer who were treated with lumpectomy is adjuvant radiation therapy and tamoxifen in patients with ER (+) tumors with no contraindications. This is a study investigating the
Results of Whole Brain Radiation Therapy in Breast Cancer Patients with Brain Metastases Presenter: A.S. Mahmoud-ahmed Presenter's Affiliation: Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH Type of Session: Scientific Background Brain metastasis is the most common neurologic complication experienced breast cancer patients. Whole brain irradiation is a known methods of palliation for these lesions. Some previous
Axillary Lymph Node Dose With Modern Tangential Breast Radiation Presenter: Daniel ReedPresenter's Affiliation: Dept of Radiation Oncology, Univ of Washington Medical Center, Seattle, WAType of Session: ScientificBackground The computerized tomography (CT) scan has become a valuable tool in defining the location of internal mammary nodes, in the development of dose?volume histograms relating to the radiation
Accelerated Partial Breast Irradiation Via Interstitial Brachytherapy as the Sole Radiation Modality for Treatment of Early-Stage Breast Cancer Presenter: Peter Y. ChenPresenter's Affiliation: Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MIType of Session: ScientificBackground In several randomized clinical trials BCT including whole breast irradiation has been found to yield equivalent survival rates when compared to mastectomy in patients with early carcinoma
The Value of Adding Radiation to Tamoxifen in Post-Menopausal Women with Stage I Breast Cancer: A Decision Analysis Presenter: R.S. PungliaPresenter's Affiliation: Joint Center for RadiationTherapyType of Session: ScientificBackground Large randomized trials have proven that radiation therapy (RT) decreases local recurrence in post-lumpectomy patients with breast cancer. However, the effect on the development of distant metastases and overall survival is less
The Impact of Regional Nodal Radiation In Patients With Early-Stage Breast Cancer with Clinically Negative Nodes Treated with Breast-Conserving Therapy Presenter: T. VuPresenter's Affiliation: CHUQ, Pavillon Hotel-Dieu de QuebecType of Session: ScientificBackground Breast cancer is the most common cancer in women Axillary dissection is often part of breast conservation therapy (BCT) because it can decrease axillary recurrence, it helps with staging and prognosis, it guides medical oncologists in
A Randomized Trial of Tamoxifen With or Without Breast Radiation in Women With Early Breast Cancer 50 Years of Age and Over Presenter: A. FylesPresenter's Affiliation: Princess Margaret Hospital, Toronto, ON, CanadaType of Session: PlenaryBackground The search continues for a subset of women with favorable breast cancer characteristics in whom radiation may be avoided. This trial was designed to determine the effects of radiation therapy plus tamoxifen versus
Breast Cancer Patients Attitudes Towards Clinical Trials in the Radiation Oncology Clinic Versus Those Searching for Trial Information on the Internet Breast Cancer Patients Attitudes Towards Clinical Trials in the Radiation Oncology Clinic Versus Those Searching for Trial Information on the Internet Presenter: Christopher Dolinsky, MD
Radiation is an Important Component of Therapy for Patients with Stage III Breast Cancer Who Achieve a Pathological Complete Response after Neoadjuvant Chemotherapy Presenter: SE McGuirePresenter's Affiliation: Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TXType of Session: ScientificBackground Neoadjuvant chemotherapy is the standard for locally advanced breast cancer and for large operable breast cancer. A pathological complete response rate of 15-20% after neoadjuvant
Concurrent Trastuzumab and Radiation Therapy (RT) in the Adjuvant Treatment of Breast Cancer Presenter: J. R. BellonPresenter's Affiliation: Dana-Farber Cancer InstituteType of Session: ScientificBackground Her-2-Neu is overexpressed in approximately 25% of breast cancer patients and confers a worse prognosis. Adjuvant trastuzumab improves outcome in node-positive breast cancer patients with Her-2-Neu positivity and high risk node-negative
ASTRO Patient Summary: Radiation is an Important Component of Therapy for Patients with Stage III Breast Cancer Who Achieve a Pathological Complete Response after Neoadjuvant Chemotherapy Radiation is an Important Component of Therapy for Patients with Stage III Breast Cancer Who Achieve a Pathological Complete Response after Neoadjuvant Chemotherapy Patients who present with locally advanced breast cancer (spread to local lymph nodes or local tissue) or large operable tumors are usually treated with chemotherapy prior to surgical
ASTRO Patient Summary: Concurrent Trastuzumab and Radiation Therapy (RT) in the Adjuvant Treatment of Breast Cancer Concurrent Trastuzumab and Radiation Therapy (RT) in the Adjuvant Treatment of Breast Cancer Patients with Her2/neu positive breast cancer are considered to have higher risk disease, but have an additional therapy option in trastuzumab (Herceptin). Doctors would like to administer trastuzumab during the same time period as the radiation therapy,
Phase III Randomized Study of Intensity Modulated Radiation Therapy vs. Standard Wedging Adjuvant Breast Radiotherapy Presenter: Jean-Philippe Pignol, M.D.Presenter's Affiliation: Sunnybrook and Women's College Health Sciences Centre, Toronto , Ontario , CanadaType of Session: PlenaryBackground The current standard adjuvant treatment of localized breast cancer is whole breast radiotherapy Prior to using modern 3-D planning techniques, opposed tangent
Long-Term Results of a Randomized Trial of Tamoxifen With or Without Radiation in Women Over 50 Years of Age With T1/2 N0 Breast Cancer Presenter: A. FylesPresenter's Affiliation: Princess Margaret HospitalType of Session: ScientificBackground Multiple studies have attempted to define a population of women with early stage breast cancer in whom the inclusion of radiation as a part of breast conservation treatment is not necessary This report represents long-term results
Five year results of Intergroup Study E5194: local excision alone (without radiation treatment) for selected patients with ductal carcinoma in situ (DCIS) Presenter: L. Hughes Affiliation: Eastern Cooperative Oncology Group Background Based on results of large randomized trials studying adjuvant treatment for excised ductal carcinoma in situ, adjuvant breast radiation is the gold standard to reduce the risk of local recurrence Retrospective analyses have attempted to identify favorable
Chest Wall Radiation Alone for Breast Cancer Patients With 1-3 Positive Lymph Nodes Treated by Mastectomy Presenter: Shannon M. MacDonald, MDPresenter's Affiliation: Massachusetts General HospitalType of Session: ScientificBackground Numerous studies have demonstrated that the administration of adjuvant comprehensive postmastectomy radiation, which includes radiation to the chest wall and supraclavicular region, reduces locoregional recurrences
Impact of Postoperative Radiation Therapy on Postmastectomy Breast Reconstruction Presenter: L.C. KeilerPresenter's Affiliation: University Hospital of Cleveland, Cleveland, OHType of Session: ScientificBackground Despite improvements in early-detection of breast cancer, many patients still present with disease requiring surgical intervention with mastectomy. Post-mastectomy radiation treatment (PMRT) is recommended
Initial Efficacy Results of RTOG 0319: Three Dimensional Conformal Radiation Therapy (3D-CRT) Confined to the Region of the Lumpectomy Cavity for Stage I/II Breast Carcinoma Presenter: F.A. ViciniPresenter's Affiliation: William Beaumont Hospital, Royal Oak, MIType of Session: ScientificBackground Breast conservation treatment, consisting of lumpectomy followed by radiotherapy, has been demonstrated in large trials to be equivalent to mastectomy for treatment of early-stage breast cancer (Fisher B, NEJM, 2002).
Results of the Phase III ENRICH (RT-016) Study of Efaproxiral Administered Concurrently with Whole Brain Radiation Therapy (WBRT) in Women with Brain Metastases from Breast Cancer Presenter: J. H. SuhPresenter's Affiliation: Cleveland Clinic, Cleveland, OHType of Session: ScientificBackground Brain metastasis is a common and deadly complication of many cancers, including lung, breast, renal cell, melanoma, and others. 170,000 individuals are diagnosed with new brain metastases annually in the United States.
Low-risk Breast Ductal Carcinoma In Situ (DCIS): Results From the Radiation Therapy Oncology Group 9804 Phase 3 Trial Abstract # 11 Presenter: Beryl McCormick Affiliation: Memorial Sloan Kettering Cancer Center, New York Background Several randomized clinical trials have demonstrated the benefit of adjuvant radiation therapy on local control for women with ductal carcinoma in situ (DCIS) of the breast following lumpectomy with breast conversation
Interim Toxicity Results from RAPID: A Randomized Trial of Accelerated Partial Breast Irradiation (APBI) Using 3D Conformal External Beam Radiation Therapy (3D-CRT) Abstract number: Plenary # 5 Presenter: Timothy J Whelan Affiliation: Ontario Clinical Oncology Group Background Accelerated partial breast irradiation (APBI) is defined as the delivery of large dose per fraction to the surgical cavity as part of a breast conservation approach (lumpectomy followed by radiation) The smaller treatment
Brown Bag Web Chat: Life After Breast Cancer Date: October 28, 2011 Time: 1:15 - 2:15 pm EST Join the OncoLink Team for a live, interactive webchat on breast cancer. Our experts will address your questions during the live event, or you can submit questions ahead of time. You can use your (public) Twitter account to participate during the live event (use the hashtag #oncochat). Focus on
Understanding Breast Cancer Supportive Care Issues - Brown Bag Chat Join us for a lunch time LIVE Web Chat with OncoLink's Breast Cancer Supportive Care Experts on October 22, 2009 at 12:30-1:30pm EST. You can submit questions during the chat or ahead of time. A transcript of the chat will be available after the event. Submit a Question Now! Understanding Breast Cancer Supportive Care Issues Have questions