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Tamoxifen for weakly positive Estrogen and Progesterone breast cancers Dear OncoLink "Ask The Experts," I am a 31-year old ER negative and "weakly" PR positive breast cancer patient. I have had a mastectomy with no lymph node involvement and chemotherapy and now deciding whether to go on Tamoxifen. Does your practice recommend Tamoxifen for "weakly" PR positive patients?Julia Draznin Maltzman, MD,
Tamoxifen Therapy for Estrogen Receptor Negative Breast Cancer Dear OncoLink "Ask the Experts," I am a medical student with a parent who is currently undergoing treatment for breast cancer. I understand that tamoxifen is used for breast cancers and is highly effective in preventing recurrence. However, what is the situation when a breast cancer is weakly estrogen receptor positive? What is the action
Estrogen receptor negative breast cancers Dear OncoLink "Ask The Experts," Does breast cancer run along some continuum from estrogen-receptor positive to estrogen-receptor negative tumors? Are ER+ tumors a different disease than ER- tumors? I have been diagnosed with an ER- breast cancer and I am confused as to whether I am at increased risk of recurrence and general guidelines for
Comparison Of Lumpectomy Plus Tamoxifen With And Without Radiotherapy (RT) In Women 70 Years Of Age Or Older Who Have Clinical Stage I, Estrogen Receptor Positive (ER+) Breast Carcinoma Presenter: Kevin S. Hughes Affiliation: Massachusetts General Hospital Background: No survival impact of RT from previous studies. Tumor in this group of pts grow slowly, therefore, less time at risk. This study is designed to assess, in this population, whether RT, when added to tamoxifen: 1) decreases locoregional recurrence, 2)
Overall Survival After Cyclophosphamide, Adriamycin, 5-FU, And Tamoxifen (CAFT) Is Superior To T Alone In Postmenopausal, Receptor (+), Node (+) Breast Cancer: New Findings From Phase III Southwest Oncology Group Intergroup Trial S8814 (INT-0100) Presenter: Kathy Albain Affiliation: Loyola Univ. Med. Center, Maywood, IL Background: The treatment of older women with breast cancer presents many unique treatment issues. One such issue is the use of anthracyclines to treat older patients who are receptor positive and node positive. The objectives of INT-0100 were to determine 1) if
Tamoxifen (Nolvadex®) Pronounced: ta-MOX-i-fen Classification: Antiestrogen About Tamoxifen Tamoxifen works by blocking estrogen receptors in breast tissue. While estrogen may not actually cause breast cancer, it is necessary for the cancer to grow in estrogen receptor-positive breast cancers. With estrogen blocked, the cancer cells that feed off estrogen may

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