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NCI CANCERLIT® Search: Salivary Gland Cancer - July 2002
National Cancer Institute®
Ultima Vez Modificado: 1 de julio del 2002
- Long-standing mucosa-associated lymphoid tissue lymphoma of the parotid gland: CT and MR imaging findings.
- [Metastasis in submandibular gland from a leiomyosarcoma of the uterus]
- Chronic eosinophilic pneumonia associated with T-cell lymphoma.
- [Pleomorphic adenoma of the parotid gland]
- Primary salivary clear cell tumors--a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with
- Natural killer-like T-cell lymphoma of the parotid in a patient infected with human immunodeficiency virus.
- Spontaneous regression of metastatic malignant melanoma of the parotid gland and neck lymph nodes: a case report and a review of the
- [Pleomorphic adenoma of the parotid gland in childhood]
- Diagnosis and radiologic manifestations of malignant dumbbell tumors of the parotid gland: review and 2 case reports.
- Parotid neoplasms: diagnosis, treatment, and intraparotid facial nerve anatomy.
- Preliminary steps in the diagnosis of the pleomorphic adenoma.
- Tuberculous parotitis: a forgotten entity.
- Hyalinizing clear cell carcinoma of salivary glands: a study of extracellular matrix.
- Assessment of dynamic MRI of Warthin's tumors arising as multiple lesions in the parotid glands.
- Primary high-grade mucoepidermoid carcinoma of the minor salivary glands with cutaneous metastases at diagnosis.
- Residual and recurrent parotid gland neoplasm after surgical excision.
- Low-grade mucoepidermoid carcinoma of salivary glands: characteristic immunohistochemical profile and evidence of striated duct
- Sebaceous differentiation in basal cell adenocarcinoma of the submandibular gland.
- Parotid lipoadenoma with sclerotic and polycystic changes.
- [Rhabdomyosarcoma of parotid gland in 4 years old boy]
- [The case of gigantic pleomorphic adenoma of the parotid gland]
- Basal cell carcinoma metastatic to the parotid stroma.
- Metastatic astrocytoma in the parotid.
- Undifferentiated sarcoma of the parotid gland with osseous metaplasia.
- Monoclonal gammopathy after low-grade MALT lymphoma: evidence for a second neoplasm.
- Oncocytic neoplasms of the parotid gland: a 16-year institutional review.
- Pleomorphic adenoma of the buccal space.
Table of Contents
1
UI - 12034639
AU - Tagnon BB; Theate I; Weynand B; Hamoir M; Coche EE
TI -
Long-standing mucosa-associated lymphoid tissue lymphoma of the parotid
gland: CT and MR imaging findings.
SO - AJR Am J Roentgenol 2002 Jun;178(6):1563-5
AD - Department of Radiology, Cliniques Universitaires St-Luc, Universite
Catholique de Louvain, Ave. Hippocrate, 10, B-1200 Brussels, Belgium.
2
UI - 11998523
AU - Burgos Sanchez AJ; Papi M; Talavera J; Trigueros M
TI -
[Metastasis in submandibular gland from a leiomyosarcoma of the uterus]
SO - Acta Otorrinolaringol Esp 2002 Jan;53(1):67-70
AD - Servicio ORL, Hospital General Universitario, Alicante.
Two general types of metastases should be distinguished in metastatic
salivary gland tumors: one of them are tumors originating in the head
and neck region, and the other are tumors from distant tumor sites.
Distant metastasis affecting the submandibular gland are a rare entity.
We report a case of the uterus leiomyosarcoma which metastatised in the
submandibular gland.
3
UI - 11936394
AU - Thiruchelvam JK; Penfold CN; Akhtar S
TI -
Chronic eosinophilic pneumonia associated with T-cell lymphoma.
SO - Int J Oral Maxillofac Surg 2002 Feb;31(1):112-4
AD - Department of Oral & Maxillofacial Surgery, Glan Clwyd Hospital, Rhyl,
UK.
A case of a woman presenting with a parotid swelling is described. She
had chronic eosinophilic pneumonia (CEP) for approximately 2 years prior
to presentation. After further investigation she had biopsy of her
parotid, which proved to be T-cell lymphoma. This is a rare association,
the diagnosis and the management of this condition is discussed.
4
UI - 11933672
AU - Paranque AR; Breton P; Ben Slama L; Bertrand JCh; Goga D
TI -
[Pleomorphic adenoma of the parotid gland]
SO - Rev Stomatol Chir Maxillofac 2002 Feb;103(1):56-61
AD - Service de Stomatologie, Chirurgie Maxillo-faciale et Chirurgie
Plastique de la face, HIA Begin, 94163 Saint-Mande.
5
UI - 12033955
AU - Wang B; Brandwein M; Gordon R; Robinson R; Urken M; Zarbo RJ
TI -
Primary salivary clear cell tumors--a diagnostic approach: a
clinicopathologic and immunohistochemical study of 20 patients with
clear cell carcinoma, clear cell myoepithelial carcinoma, and
epithelial-myoepithelial carcinoma.
SO - Arch Pathol Lab Med 2002 Jun;126(6):676-85
AD - Lillian and Henry M. Stratton-Hans Popper Department of Pathology, The
Mount Sinai School of Medicine, New York, NY 10021, USA.
CONTEXT: Primary salivary clear cell tumors comprise an uncommonly
encountered subgroup of salivary neoplasia. We hypothesize that clear
cell carcinoma does not represent a "monomorphic" variant of
epithelial-myoepithelial carcinoma, but is distinct in terms of
histogenesis and tumor biology. OBJECTIVES: To compare the
clinicopathologic features of 20 cases of salivary primary clear cell
tumors, including 12 clear cell carcinomas (CCCs), 7
epithelial-myoepithelial carcinomas (EMECs), and 1 clear cell
myoepithelial carcinoma (CCMEC); to investigate their interrelationship
with regard to myoepithelial differentiation; and to offer a diagnostic
approach for distinguishing between these entities. DESIGN:
Retrospective and prospective identification and review of patients
diagnosed with primary salivary clear cell neoplasia and review of the
English language literature. SETTING: Three academic tertiary-care
hospitals. PATIENTS: We identified 12 patients with CCC, 7 with EMEC,
and 1 with CCMEC. Patients included 11 men and 9 women, aged 30 to 88
years (median 72.5 years). MAIN OUTCOME MEASURES: Immunohistochemical
reactivity for S100, muscle-specific actin, and calponin;
ultrastructural examination when feasible; review of patient charts; and
telephone interviews to establish clinical outcome. RESULTS: Clear cell
carcinoma has a predilection for intraoral sites, whereas EMEC has a
predilection for the parotid. All 3 of the tumor types studied have a
propensity for locoregional recurrence, which can manifest decades after
initial surgery. There were no mortalities among patients with CCC, even
after pulmonary metastasis in 2 patients, confirming the indolent nature
of this group of clear cell tumors. A meta-analysis of reported cases of
CCC, EMEC, and CCMEC confirmed that EMEC and CCMEC have a much greater
propensity for locoregional recurrence than CCC, despite the
predilection of both for a more surgically accessible site (parotid). We
found no definitive evidence of myoepithelial differentiation in CCC,
indicating that it is probably morphogenetically distinct from EMEC and
CCMEC, both tumors with diagnostically requisite myoepithelial
differentiation. CONCLUSIONS: The initial treatment of choice for CCC,
CCMEC, and EMEC is surgical resection with negative margins.
Locoregional recurrence should be treated aggressively, as it is still
consistent with long disease-free intervals. The lack of myoepithelial
differentiation in CCC is consistent with the concept that this tumor is
histomorphogenically distinct from EMEC and that it is not merely a
monomorphic variant.
6
UI - 12033970
AU - Cornfield DB; Papiez JS; Lynch JT; Rimsza LM
TI -
Natural killer-like T-cell lymphoma of the parotid in a patient infected
with human immunodeficiency virus.
SO - Arch Pathol Lab Med 2002 Jun;126(6):738-41
AD - Department of Pathology, University of Florida College of Medicine,
Gainesville, USA. cornf1@dca.net
A 42-year-old man with acquired immunodeficiency syndrome developed a
mass of the right parotid gland and multiple hepatic masses.
Hematoxylin-eosin-stained sections of the parotid lesion showed a
diffuse infiltrate of large mononuclear cells with vesicular nuclei and
prominent nucleoli, consistent with a non-Hodgkin lymphoma.
Immunohistochemical stains demonstrated expression of the T-cell markers
CD3 and UCHL-1, as well as latent membrane protein 1 and T-cell
intracellular antigen 1. Flow cytometry showed surface expression of
CD2, CD3, CD7 (dim), CD8, and CD56. CD5 was not expressed. Molecular
evaluation by polymerase chain reaction demonstrated monoclonal
rearrangement of the T-cell receptor gamma gene. Epstein-Barr virus
early RNA and human immunodeficiency virus RNA were demonstrated by in
situ hybridization. To our knowledge, this is the first reported case of
T-cell lymphoma of the parotid in a patient infected with human
immunodeficiency virus. After 2 separate chemotherapy regimens, the
patient achieved clinical remission for 1(1/2) years; he then developed
progressive pulmonary lesions and died.
7
UI - 11824888
AU - King M; Spooner D; Rowlands DC
TI -
Spontaneous regression of metastatic malignant melanoma of the parotid
gland and neck lymph nodes: a case report and a review of the
literature.
SO - Clin Oncol (R Coll Radiol) 2001;13(6):466-9
AD - Queen Elizabeth Centre for the Treatment of Cancer, University Hospitals
Birmingham NHS Trust, UK.
We report the case history of a patient with complete spontaneous
regression of metastatic cutaneous melanoma with parotid and neck lymph
node metastases. Complete spontaneous regression of metastatic melanoma
is very rare, with an estimated incidence of 0.22%-0.27%. We review the
literature on this subject. Elucidation of the process of spontaneous
regression may offer the possibility of improved methods of treating and
preventing cancer.
8
UI - 11535976
AU - Giudice M; Itro A; Marra A; Amodio A
TI -
[Pleomorphic adenoma of the parotid gland in childhood]
SO - Minerva Stomatol 2001 Jun;50(6):205-11
AD - Facolta di Medicina e Chirurgia, Dipartimento Assistenziale di Patologia
della Testa e del Collo, Orale e Maxillo-Facciale, Cattedra e Servizio
di Pedodonzia Chirurgica, II Universita degli Studi, Naples, Italy.
BACKGROUND: The authors report the results of ten years' activity at the
Pedodontic Surgery Unit in the Institute of Maxillofacial Surgery at the
Second University of Naples and analyse the possibility of conservative
treatment of pleomorphic adenoma in childhood. METHODS: The study
includes 614 cases of salivary gland pathology. The authors illustrate
the epidemiological, clinical and therapeutic characteristics of this
type of lesion in childhood, emphasising that the data emerging from
this study do not differ from the clinical and therapeutic management of
pleomorphic adenoma in young patients reported in the literature.
RESULTS: In particular, they emphasise that satisfactory therapeutic
results can be achieved using conservative techniques, like conservative
superficial parotidectomy. CONCLUSIONS: Conservative superficial
parotidectomy has the advantage of being less radical and traumatic for
a young patient, without provoking a significant increase in
recidivation.
9
UI - 11925549
AU - Hakim SG; Sieg P
TI -
Diagnosis and radiologic manifestations of malignant dumbbell tumors of
the parotid gland: review and 2 case reports.
SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Mar;93(3):362-8
AD - Department of Maxillofacial Surgery, Medical University of Luebeck,
Germany.
Primary malignant dumbbell tumors represent a special growth type of
deep-lobe parotid neoplasm. Because they are located in an anatomically
limited space between the skull base and the mandibular ramus, they do
not cause any but a few nonspecific symptoms and may metastasize into
the neck or distant organs before the primary tumor has ever been
diagnosed. This article describes 2 cases that first presented as
asymptomatic carcinoma unknown primary syndrome and were later
discovered to be malignant dumbbell tumors of the parotid gland. Because
adequate evaluation is essential for the subsequent management, several
diagnostic methods available for the differential diagnosis of this
tumor are discussed; we compare these according to their relevance to
the therapeutic procedure. Magnetic resonance imaging was found to be
the most appropriate imaging technique because of its ability to help us
better differentiate between tumor and surrounding tissue. Computed
tomography and single photon emission computed tomography can help us
identify involvement of the skull base and mandibular ramus.
10
UI - 12080993
AU - Tsai SC; Hsu HT
TI -
Parotid neoplasms: diagnosis, treatment, and intraparotid facial nerve
anatomy.
SO - J Laryngol Otol 2002 May;116(5):359-62
AD - Department of Otolaryngology, Shin Kong Wu Ho-Su Memorial Hospital,
Taipei, ROC.
The demographics of parotid neoplasms in different populations have been
reported by various centres. In this investigation, we reviewed
retrospectively all the in-patient and out-patient charts and records of
108 patients who were diagnosed with parotid neoplasms and received
Patient age, gender, tumour pathology, fine-needle aspiration cytology
results, and the intraparotid anatomy of the facial nerve were noted. We
showed that despite the difference between our Taiwanese and previously
studied patient populations, both populations had a similar
distribution, diagnosis and treatment of parotid neoplasms, although the
incidence of parotid tuberculosis was higher in our patient group. In
addition, the facial nerve anatomy within the parotid gland had three
main branching patterns in the upper and lower division.
11
UI - 12066368
AU - Linsky H; Mandel L
TI -
Preliminary steps in the diagnosis of the pleomorphic adenoma.
SO - N Y State Dent J 2002 May;68(5):28-31
Patients with parotid swellings are often first seen in the dental
office. The dental practitioner must be able to differentiate a
neoplastic lesion from other causes of parotid swelling. Knowledge of
the modalities that are available to distinguish the presence of a tumor
and whether the tumor is benign or malignant is mandatory. The authors
present a case report to illustrate the techniques that are used in the
preliminary diagnosis of the benign pleomorphic adenoma. Final diagnosis
awaits the microscopic examination of a surgical specimen.
12
UI - 12075235
AU - Hamdan AL; Hadi U; Shabb N
TI -
Tuberculous parotitis: a forgotten entity.
SO - Otolaryngol Head Neck Surg 2002 May;126(5):581-2
AD - Department of Otolaryngology-Head and Neck Surgery, American University
of Beirut Medical Center, New York, NY 10022-6297, USA.
13
UI - 12076700
AU - Felix A; Rosa JC; Nunes JF; Fonseca I; Cidadao A; Soares J
TI -
Hyalinizing clear cell carcinoma of salivary glands: a study of
extracellular matrix.
SO - Oral Oncol 2002 Jun;38(4):364-8
AD - Departamento de Patologia Morfologica, Instituto Portugues de Oncologia
de Francisco Gentil, Rua Professor Lima Basto, 1099-023 Lisboa Codex,
Portugal. anafpinto@mail.telepac.pt
Hyalinizing clear cell carcinoma (HCCC) is a recently described
low-grade carcinoma of the salivary glands presenting two main
histological features: clear neoplastic cells and prominent hyalinized
stroma. Our aim was to characterize the composition of the hyalinized
stroma in three cases of HCCC. An immuno-histochemical study using
laminin and type I, III and IV collagens, fibronectin and tenascin
antibodies was performed. In one case, electron microscopy study was
also done. Collagen I and fibronectin were always present in tumoral
stroma. Collagen III was documented in two cases and tenascin at the
invasive front of the neoplasm. Collagen IV and laminin were found
around neoplastic cells but not at the interstitial stroma. Foci of
basal lamina reduplication and large deposits of long space collagen
were observed in EM. This study demonstrates that the hyalinized stroma
of HCCC is not formed by the accumulation of basement membrane-type
material since it is mostly composed by collagen I and fibronectin.
14
UI - 12076701
AU - Hisatomi M; Asaumi J; Konouchi H; Yanagi Y; Matsuzaki H; Kishi K
TI -
Assessment of dynamic MRI of Warthin's tumors arising as multiple
lesions in the parotid glands.
SO - Oral Oncol 2002 Jun;38(4):369-72
AD - Department of Oral Radiology, Okayama University Dental School, 2-5-1,
Shikata-cho, Okayama-city, Okayama 700-8525, Japan.
tomi@md.okayama-u.ac.jp
We examined three patients with multiple synchronous Warthin's tumors in
the bilateral parotid and described the value of using dynamic MRI. The
time course of the contrast index (CI curves) was calculated from a
dynamic series. Warthin's tumors showed intermediate signal intensity on
T1WI, heterogeneous high and intermediate signal intensity on T2WI and a
slight enhancement on Gd-T1WI. Warthin's tumors of CI curves showed
specific findings. CI curves in each lesion showed the same pattern. It
was difficult to diagnose masses as Warthin's tumors using only MR
images on T1, T2 and Gd-T1WI. Dynamic MRI can distinguish Warthin's
tumors from other possible tumors except for oncocytoma. Therefore, the
use of dynamic MRI is recommended as a diagnostic method for Warthin's
tumors in multiple synchronous lesions of the parotid gland.
15
UI - 12076708
AU - Locati LD; Quattrone P; Pizzi N; Fior A; Cantu G; Licitra L
TI -
Primary high-grade mucoepidermoid carcinoma of the minor salivary glands
with cutaneous metastases at diagnosis.
SO - Oral Oncol 2002 Jun;38(4):401-4
AD - Department of Medical Oncology, Istituto Nazionale Tumori, Via Venezian
1, 20133, Milan, Italy.
Mucoepidermoid carcinoma (MEC) represents 15% of all salivary glands
malignancies. Metastatic disease at diagnosis is observed in less than
5% of the cases. The lung is the most commonly involved site. This is
the first reported case of high-grade MEC of the salivary gland with
skin metastases at diagnosis. This feature was associated with a
chemoresistant and aggressive behaviour. Differential diagnosis between
metastatic MEC and primary skin MEC is essential for therapeutic
management and prognosis.
16
UI - 12081344
AU - Ezeanolue BC
TI -
Residual and recurrent parotid gland neoplasm after surgical excision.
SO - West Afr J Med 2002 Jan-Mar;21(1):5-8
AD - Department of Otolaryngology, University of Nigeria Teaching Hospital,
Enugu.
Ten patients who presented with residual or recurrent parotid gland
factors responsible for the persistence or recurrence of the tumour
after surgical excision. The 10 patients comprised of four males and six
females. Their ages ranged from 33 to 73 years with a mean of 52 years.
Seven were of malignant histologic cell types while three were benign.
Eight patients were treated with secondary parotidectomy while two
received combination chemotherapy. In five patients, both the
superficial and deep lobes of the parotid gland were found during
secondary parotidectomy. This confirms that the extent of the initial
surgery was less than superficial parotidectomy. This confirms that the
extent of the initial surgery was less than superficial parotidectomy.
Four patients were later referred to radiotherapy centers for further
treatment It is concluded that most recurrent parotid neoplasm is a
result of inadequate primary surgical excision, and best results are
obtained by doing a minimum of superficial parotidectomy in the surgical
treatment of parotid gland neoplasms.
17
UI - 12021929
AU - Foschini MP; Marucci G; Eusebi V
TI -
Low-grade mucoepidermoid carcinoma of salivary glands: characteristic
immunohistochemical profile and evidence of striated duct
differentiation.
SO - Virchows Arch 2002 May;440(5):536-42
AD - Department of Oncology, Section of Anatomic Pathology, M. Malpighi
University of Bologna, Ospedale Bellaria, Via Altura 3, 40139 Bologna,
Italy. mariapia.foschini@ausl.bologna.it
The purpose of the present study is to determine the presence and
distribution of epithelial and myoepithelial cells in mucoepidermoid
carcinoma (MEC) of salivary glands and to compare them with normal
salivary gland tissue and other primary carcinomas. This is in order to
establish novel diagnostic criteria and to better understand MEC
histogenesis. Formalin-fixed paraffin-embedded tissues from ten
well-differentiated MECs, three adenoid cystic carcinomas (ACC), four
acinic cell carcinomas (AC), and three epithelial-myoepithelial
carcinomas (EMCC) of salivary glands were studied with
immunohistochemistry using antibodies that recognise antigens indicative
of epithelial and myoepithelial cell differentiation. An
anti-mitochondrial antibody was also employed. Normal salivary tissue
was present for comparative study in non-tumorous areas of the same
section from 12 cases. MEC contained numerous keratin-positive cells.
Anti mitochondrial antibody was diffusely positive in all ten of these
tumours. Smooth muscle actin, h-caldesmon, and smooth muscle heavy chain
myosin, which are indicative of myoepithelial cell differentiation, were
negative. Rare cells in only one case were stained by calponin.
Cytokeratin 14 (CK14) and anti mitochondrial antibody stained cells
located mainly at the periphery of neoplastic nests and cystic spaces,
while CK7 was mainly present in cells bordering gland lumina (zoning
pattern). The immunohistochemical cell profile was similar to that seen
in striated normal ducts. All others tumours studied showed a different
immunohistochemical pattern, mostly consisting of a lack of
mitochondrion-rich cells and the presence of myoepithelial cells in ACC
and EMCC. Immunoreactivity in MEC for CK7, CK14 and mitochondrial
antibodies appears as a peculiar pattern of staining, different from
that of other salivary gland tumors; this seems helpful for diagnostic
purposes. In addition, a differentiation of the "striated duct
phenotype" is suggested.
18
UI - 12021931
AU - Ide F; Kusama K
TI -
Sebaceous differentiation in basal cell adenocarcinoma of the
submandibular gland.
SO - Virchows Arch 2002 May;440(5):547-8
19
UI - 12021932
AU - Hirokawa M; Bando Y; Tashiro T; Kuma S; Kawata I; Sano T
TI -
Parotid lipoadenoma with sclerotic and polycystic changes.
SO - Virchows Arch 2002 May;440(5):549-50
20
UI - 12094655
AU - Polawska K
TI -
[Rhabdomyosarcoma of parotid gland in 4 years old boy]
SO - Otolaryngol Pol 2002;56(2):249-53
AD - Katedra i Klinika Chorob Uszu, Nosa, Gardla i Krtani AM w Gdansku.
The author described the case of parotid gland rhabdomyosarcoma in 4
years old boy. As there was no parents agreement to initial, radical
surgical treatment, the patient underwent chemo- and radiotherapy, after
which temporary remission of the disease was observed. The surgical
treatment was performed for local recurrence, but despite radical
parotidectomy, which was done, the progression of disease was occurred
(with local recurrence and bone metastases). The patient died 3 years
after initial diagnosis.
21
UI - 12094657
AU - Zawislak J; Polberg K
TI -
[The case of gigantic pleomorphic adenoma of the parotid gland]
SO - Otolaryngol Pol 2002;56(2):259-62
AD - Oddzial Laryngologii Szpitala Wojewodzkiego w Zamosciu.
The authors describe case of big size pleomorphic adenoma of the parotid
gland. This tumor lead to cachexia and to elimination of life in
society. Attention was paid on the surgical treatment of pleomorphic
adenomas by superficial or total parotidectomies. Possibility of the
post operative complications avoidance, even in such big cases was
emphasized. Recurrence was not observed during 10 months follow up. Use
of surgical treatment make that the patient was able to return to her
previous job.
22
UI - 11910236
AU - Benlier E; Kilinc N; Erdem I
TI -
Basal cell carcinoma metastatic to the parotid stroma.
SO - Ann Plast Surg 2002 Feb;48(2):217-8
23
UI - 12060086
AU - Raut V; Golchin K; Anderson N; Primrose WJ
TI -
Metastatic astrocytoma in the parotid.
SO - Cytopathology 2002 Jun;13(3):186-8
24
UI - 12088457
AU - Wajstaub S; Deb P; Chorneyko KA
TI -
Undifferentiated sarcoma of the parotid gland with osseous metaplasia.
SO - Arch Pathol Lab Med 2002 Jul;126(7):849-52
AD - Department of Pathology and Molecular Medicine, St Joseph's Healthcare
and McMaster University, Hamilton, Ontario, Canada.
Malignant spindle cell tumors of the parotid gland are a diagnostic
challenge. We present an unusual case of such a tumor that occurred in
the right parotid gland of a 53-year-old man. The clinical and
histologic assessments were consistent with a primary sarcoma of the
parotid gland. The tumor was composed of sheets of pleomorphic,
spindle-shaped cells with an area of bone formation. By
immunohistochemistry, the tumor cells were positive for vimentin and
negative for epithelial markers. Electron microscopy revealed
mesenchymal cells containing moderate amounts of rough endoplasmic
reticulum. The major differential diagnostic considerations were spindle
cell carcinoma, carcinosarcoma, and primary undifferentiated sarcoma
with osseous metaplasia. The lack of epithelial features and the benign
appearance of the bone formation led to a diagnosis of undifferentiated
sarcoma of the parotid gland.
25
UI - 12111792
AU - Pachmann S; Anderegg B; Muller-Hocker J; Nathrath W; Brack N; Tigges FJ;
TI -
Hartenstein R; Munker R
Monoclonal gammopathy after low-grade MALT lymphoma: evidence for a
second neoplasm.
SO - Am J Hematol 2002 Jun;70(2):167-73
AD - Stadtisches Krankenhaus Munchen-Harlaching (Departments of Medicine IV
and Pathology), Pathologisches Institut der
Ludwig-Maximilians-Universitat, Munich, Germany.
We report the case of a patient with lymphoma of the salivary gland, at
first diagnosed as lymphoma of mucosa-associated lymphoid tissue (MALT
lymphoma) but later found to infiltrate the bone marrow. At diagnosis,
the patient had a polyclonal increase of gamma-globulins. Five years
after initial diagnosis, the patient presented with monoclonal
gammopathy and infiltration of the bone marrow with neoplastic cells.
Initially, the patient had received chemotherapy with different
protocols (including etoposide, cyclophosphamide, fludarabin,
methotrexate, and vincristine), none of which induced a lasting
response. Therapy with rituximab (chimeric anti-CD20 monoclonal
antibody) finally led to partial remission. Eighteen months after
rituximab, progressive lymphoma in the abdomen and a monoclonal
gammopathy developed. The bone marrow showed infiltration by
lymphoplasmacytoid cells (monoclonal expression of the light-chain type
lambda, positive for CD20, heterogeneous expression of CD45). The
patient achieved another short clinical response with 4 cycles of the
CHOP-protocol, but soon the lymphoma progressed again. Five years and 8
months after the initial diagnosis, the patient died from septicemia and
progressive lymphoma. By polymerase chain reaction (PCR) for the IgH
gene it was shown that lymphoma cells were initially oligoclonal in the
salivary gland and, later, biclonal in the bone marrow. Sequencing of
two bands of apparently same length showed that these manifestations of
lymphoma were not identical. Taken together, our data show that the
initial low-grade oligoclonal MALT lymphoma was no longer present and a
more aggressive biclonal lymphoma with plasmacytoid differentiation had
developed. The new lymphoma was clonally distinct and produced high
amounts of monoclonal IgG lambda by immunoelectrophoresis. The
relationship of the second lymphoma to the initial MALT lymphoma is
discussed. Copyright 2002 Wiley-Liss, Inc.
26
UI - 12087334
AU - Capone RB; Ha PK; Westra WH; Pilkington TM; Sciubba JJ; Koch WM;
TI -
Cummings CW
Oncocytic neoplasms of the parotid gland: a 16-year institutional
review.
SO - Otolaryngol Head Neck Surg 2002 Jun;126(6):657-62
AD - Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins
University School of Medicine, Baltimore, MD 21287, USA.
BACKGROUND: Oncocytic neoplasms of the parotid gland are a rare
collection of salivary gland tumors that include oncocytosis,
oncocytoma, and oncocytic carcinoma. Mounting evidence has linked the
presence of oncocytes to acquired mitochondrial dysfunction. OBJECTIVES:
The study goals were to further delineate this poorly understood group
of salivary gland tumors and to search for genetic alterations
indicative of mitochondrial dysfunction. METHODS: Cases were identified
by search of the surgical pathology archival files from 1984 through
2000. Corresponding medical records were reviewed. Tumor mitochondrial
DNA (mtDNA) was evaluated for mtDNA mutations within the control region
(C-tract). RESULTS: Twenty-one parotid oncocytic neoplasms were
identified. Oncocytoma was the most frequent morphology (62%), followed
by oncocytosis (28.5%) and oncocytic carcinoma (9.5%). One specimen
displayed synchronous oncocytic morphologies (oncocytoma, oncocytosis,
and oncocytic metaplasia). One oncocytoma specimen displayed the mtDNA
C-tract alteration. CONCLUSIONS: Oncocytic neoplasia of the parotid
gland is a rare form of salivary gland disease with obscure etiology.
The presence of multiple oncocytic morphologies in a single specimen is
suggestive of transition between forms. Although oncocytic tumorigenesis
secondary to acquired mitochondrial dysfunction is a plausible
mechanism, few of these tumors actually harbor mtDNA alterations within
the control region.
27
UI - 12087341
AU - Pontius AT; Myers LL
TI -
Pleomorphic adenoma of the buccal space.
SO - Otolaryngol Head Neck Surg 2002 Jun;126(6):695-6
AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas
Southwestern Medical Center, Dallas 75390-9035, USA.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
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