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NCI CANCERLIT^® Search: Li-Fraumeni Syndrome - June 2002

Imprima English

National Cancer Institute^®
Ultima Vez Modificado: 1 de junio del 2002

The IARC TP53 database: new online mutation analysis and recommendations to users.

Table of Contents

1
UI - 12007217
AU - Olivier M; Eeles R; Hollstein M; Khan MA; Harris CC; Hainaut P
TI - The IARC TP53 database: new online mutation analysis and recommendations to users.
SO - Hum Mutat 2002 Jun;19(6):607-14
AD - Molecular Carcinogenesis Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Mutations in the tumor suppressor gene TP53 are frequent in most human cancers. Comparison of the mutation patterns in different cancers may reveal clues on the natural history of the disease. Over the past 10 years, several databases of TP53 mutations have been developed. The most extensive of these databases is maintained and developed at the International Agency for Research on Cancer. The database compiles all mutations (somatic and inherited), as well as polymorphisms, that have been reported in the published literature since 1989. The IARC TP53 mutation dataset is the largest dataset available on the variations of any human gene. The database is available at www.iarc.fr/P53/. In this paper, we describe recent developments of the database. These developments include restructuring of the database, which is now patient-centered, with more detailed annotations on the patient (carcinogen exposure, virus infection, genetic background). In addition, a new on-line application to retrieve somatic mutation data and analyze mutation patterns is now available. We also discuss limitations on the use of the database and provide recommendations to users. Copyright 2002 Wiley-Liss, Inc.

The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.

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