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National Cancer Institute®
Ultima Vez Modificado: 1 de febrero del 2002
UI - 11775244
AU - Deng X; Wu J; Guo X; Han X; Ding X
TI - Effect of 8-bromo-cyclic AMP on neuron specific enolase, heat shock protein, nitric oxide, nitric oxide synthase and nitric oxide synthase mRNA in human retinoblastoma HXO-Rb44 cells and cell differentiation.
SO - Chin Med J (Engl) 2000 Mar;113(3):198-200
AD - Henan Institute of Ophthalmology, Zhengzhou 450003, China.
OBJECTIVE: To study the effect of 8-bromo-cyclic AMP (8-Br-cAMP) on nitric oxide synthase (NOS) mRNA, NOS and nitric oxide (NO) product, heat shock protein (hsp) 70 and neuron specific enolase (NSE) in human retinoblastoma HXO-Rb44 cells and the effect related to cell differentiation. METHODS: Cultured human retinoblastoma HXO-Rb44 cells were divided into two aliquots. One was cultured with 2 x 10(-5) mol/L of 8-Br-cAMP for 24 hours as the experiment group; the other was treated with no 8-Br-cAMP as the control group. The cell suspensions in concentration of 1 x 10(7)/ml in both groups were dropped onto the nitrocellulose membrane (NCM). The NOS mRNA was detected with the biotin-labeled NOS cDNA probe by RNA dot blot. The NOS activity was detected by protein dot blot. The immunoreactivity (IR) of hsp70 and NSE was detected by protein dot blot. The NO was detected by nitrate reductase method. NCM specimens were analyzed by a TLC scanner for detection of the dot blot signal intensity. RESULTS: The signals of NOS mRNA, NOS activity, hsp70-IR, NSE-IR, and NO content in the experiment group were higher than those in the control group (P < 0.05-0.01). CONCLUSIONS: 8-Br-cAMP could increase NO product and the expression of NOS mRNA, NOS, NSE and hsp70. The results indicate that 8-Br-cAMP could facilitate synthesis of NO in the neuroblastoma HXO-Rb44 cells, which could have tendency toward neuron development, suggesting that the increased hsp70, NO and NOS may involve cell differentiation of the retinoblastoma HXO-Rb44.
UI - 11776612
AU - Zheng S; Ke Y
TI - [Study of APC, Rb, c-met gene copy numbers of human gastric mucosa epithelial cell line GES-1]
SO - Zhonghua Zhong Liu Za Zhi 1999 Nov;21(6):409-11
AD - Beijing Institute for Cancer Research, School of Oncology, Beijing Medical University, Beijing 100034.
OBJECTIVE: To study the copy number of oncogene/tumor suppressor genes in GES-1 cell line to identify its characteristics. METHODS: Bio-14-dATP was incorporated into APC, Rb, c-met gene cloned in plasmid by nick translation. Fluorescence in situ hybridization (FISH) of interphase nuclei of GES-1 cells was performed. RESULTS: Two copies of APC were shown in 48% interphase nuclei and 3 copies in 22%; 71% and 80% cells had normal copies of Rb and c-met genes in their nuclei, respectively. CONCLUSION: GES-1 cell line is a relatively normal gastric mucosa epithelial cell line and can be used as a human in vitro model system for the study of carcinogenesis.
UI - 11801509
AU - Gombos DS; Kelly A; Coen PG; Kingston JE; Hungerford JL
TI - Retinoblastoma treated with primary chemotherapy alone: the significance of tumour size, location, and age.
SO - Br J Ophthalmol 2002 Jan;86(1):80-3
AD - Ocular Oncology Service, St Bartholomew's Hospital, London, UK.
AIMS: To evaluate how tumour size, retinal location, and patient age affect the outcome of retinoblastoma foci treated with chemotherapy. METHODS: Retrospective review of retinoblastoma foci treated with primary chemotherapy alone. Individual tumours were coded with regard to their largest basal diameter, location within the eye (macula, macula to equator, equator to ora serrata), and patient's age at diagnosis. Successfully treated tumours required no further intervention while those requiring additional treatment were coded as failures. RESULTS: 56 (72%) tumours responded successfully to chemotherapy alone while 22 (28%) required additional therapy. 26 of 31 macular tumours (84%) and 30 of 47 extramacular tumours (64%) responded to chemotherapy (p <0.060). Relative to size, 46 of 60 tumours (77%) greater than 2 mm in basal diameter were successfully treated with chemotherapy, while only 10 of 18 tumours (56%) less than or equal to 2 mm responded (p <0.088). Among the eight tumour foci diagnosed in children less than 2 months of age, five (63%) failed to respond to chemotherapy alone (p <0.032). CONCLUSION: Retinoblastoma is more likely to respond to primary chemotherapy if it is located in the macula and if the patient is older than 2 months of age. Tumours measuring less than 2 mm in diameter may be less responsive to this treatment.
UI - 11807886
AU - Tharapel SA; Kadandale JS
TI - Primed in situ labeling (PRINS) for evaluation of gene deletions in cancer.
SO - Am J Med Genet 2002 Jan 15;107(2):123-6
AD - Cytogenetics Reference Laboratory, Pathology and Laboratory Medicine Service, V.A. Medical Center, Tennessee 38104, USA. email@example.com
Rearrangements involving the 13q14 and 17p13 chromosomal regions are often observed in leukemias and lymphomas. These rearrangements are not always identifiable cytogenetically. In more than 50% of cases, deletions occur at the submicroscopic level and the karyotypes appear normal. Molecular cytogenetic techniques such as fluorescence in situ hybridization (FISH) have accordingly contributed to the identification of a variety of subtle rearrangements such as those involving submicroscopic deletions. However, FISH is expensive, time consuming, technically burdensome, and requires cloned DNA probes. A newer technique, primed in situ labeling (PRINS), has been tested as a possible alternative to FISH. To assess the utility and efficiency of the PRINS method in the detection of RB1 and p53 deletions, we evaluated 10 patients with hematological disorders and known rearrangements, i.e., deletions involving 13q14 and 17p13 regions. The data in these cases were validated against data obtained with standard FISH probes. Our results indicate that PRINS could be used with relative ease in cytogenetics laboratories and could serve as an alternative to conventional FISH for defining deletions involving unique sequences. Copyright 2001 Wiley-Liss, Inc.
UI - 11812445
AU - Laquis SJ; Rodriguez-Galindo C; Wilson MW; Fleming JC; Haik BG
TI - Retinoblastoma in a patient with an X;13 translocation and facial abnormalities consistent with 13q-syndrome.
SO - Am J Ophthalmol 2002 Feb;133(2):285-7
AD - Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
PURPOSE: To report a patient with an X;13 translocation and facial features of 13q-syndrome who developed retinoblastoma. DESIGN: Observational case report. METHODS: A 9-month-old girl known to have an X;13 chromosomal translocation with a break point at 13q12.1 and dysmorphic facial features characteristic of 13q-syndrome presented with leukocoria in her right eye. RESULTS: By clinical examination, retinoblastoma was diagnosed in the right eye. CONCLUSION: Chromosomal abnormalities on the long arm of chromosome 13 predispose to retinoblastoma formation and characteristic facial features.
UI - 11587173
AU - Shields JA; Shields CL
TI - Differentiation of coats' disease and retinoblastoma.
SO - J Pediatr Ophthalmol Strabismus 2001 Sep-Oct;38(5):262-6; quiz 302-3
AD - Ocular Oncology Service, Wills Eye Hospital Thomas Jefferson University, Philadelphia, PA 19107, USA.
UI - 11587178
AU - Wang AG; Lai CR; Hsu WM; Liu JH; Yen MY
TI - Clinicopathologic factors related to apoptosis in retinoblastoma.
SO - J Pediatr Ophthalmol Strabismus 2001 Sep-Oct;38(5):295-301
AD - Department of Ophthalmology, Taipei Veterans General Hospital, Institute of Clinical Medicine, National Yang-Ming University Taiwan.
PURPOSE: To investigate the presence of apoptosis in retinoblastoma and its correlation with other pathologic and prognostic factors. METHODS: The pathologic and admission records of 25 patients with a pathologically confirmed diagnosis of retinoblastoma were reviewed. TUNEL (TdT dUTP nick end labeling) staining was used to examine apoptosis in the pathologic slides of these 25 patients. The association between apoptosis and clinicopathologic factors was examined with chi-square, Fisher's exact, and Student's t tests. RESULTS: Of the 25 specimens tested, 11 were TUNEL stain-positive for the presence of apoptotic cells. Apoptosis was found more frequently in younger patients and within rosettes, although these associations were not statistically significant. Apoptosis was not associated with tumor invasion or metastasis. CONCLUSION: Apoptotic cells were found in 11 of 25 retinoblastoma specimens. Apoptosis tends to occur in young patients and be distributed within rosettes.
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