National Cancer Institute®
Ultima Vez Modificado: 1 de enero del 2002
UI - 11370765
AU - Chen CH; Li BY; Wan JT; Sun A; Leu JS; Chiang CP
TI - Expression of epidermal growth factor in salivary adenoid cystic carcinoma.
SO - Proc Natl Sci Counc Repub China B 2001 Apr;25(2):90-6
AD - Department of Dentistry, School of Dentistry, China Medical College, Taichung, Taiwan, ROC.
This study used an immunohistochemical technique to assess the expression of epidermal growth factor (EGF) in 40 specimens of salivary adenoid cystic carcinoma (ACC), 7 specimens of labial glands adjacent to mucocele, and 5 specimens of normal submandibular glands. In normal submandibular glands, immunohistochemically detectable EGF was demonstrated in all ductal segments, including intercalated, striated, and excretory duct cells. No EGF positive staining was found in acinar compartments. including serous and mucous acinar cells. In degenerated labial glands adjacent to mucocele, no EGF staining was detected in the remaining acinar and ductal cells. In salivary ACCs, positive EGF immunostaining was observed in one of the 5 (20%) ACCs with a solid pattern and in 13 of the 35 (37.1%) ACCs with a tubular-cribriform pattern. The overall EGF expression rate in 40 salivary ACCs was 35%. Positive EGF staining was predominantly found in tubular structures in the tubular ACCs and in duct-like structures in large cribriform patterns or in the stroma of the cribriform ACCs. There was no significant correlation between EGF expression in salivary ACCs and any of the clinicopathological parameters including patient age and sex, cancer location, TNM status, clinical stage, histologic type, perivascular or perineural invasion, focal necrosis of tumor, and cellular atypia. We conclude that the duct segments of the normal submandibular gland are the sites of EGF synthesis and secretion. In degenerated labial glands adjacent to mucocele, EGF synthesis is completely inhibited. Furthermore, EGF is mainly biosynthesized in cells forming tubular or duct-like structures in tubular or cribriform salivary ACCs, and EGF may play a biologic role, particularly as a mitogen in salivary ACC growth.
UI - 11405064
AU - Cao Y; Karsten U
TI - Binding patterns of 51 monoclonal antibodies to peptide and carbohydrate epitopes of the epithelial mucin (MUC1) on tissue sections of adenolymphomas of the parotid (Warthin's tumours): role of epitope masking by glycans.
SO - Histochem Cell Biol 2001 Apr;115(4):349-56
AD - Max Delbruck Centre for Molecular Medicine, R.-Rossle-Strasse 10, 13125 Berlin-Buch, Germany.
Warthin's tumours provide a unique opportunity to distinguish and compare monoclonal antibodies (mAbs) to the epithelial mucin, MUC1. In this study, we have applied the range of anti-MUC1 antibodies submitted to the ISOBM TD-4 Workshop for this purpose. mAbs and lectins against MUC1-associated carbohydrate epitopes were also included. Among 39 mAbs to peptide epitopes of MUC1, eight distinct types of staining patterns towards the two epithelial cell layers of Warthin's tumours could be observed. A majority of 27 mAbs reacted preferentially (17) or exclusively (10) with columnar cells, whereas 10 mAbs favoured basal cells (1 of them almost exclusively). The observed staining patterns revealed no correlation with the epitopes. However, after carbohydrate-specific periodate oxidation, 33 of the mAbs stained columnar and basal cells equally well, indicating that epitope masking by glycan side chains was in most cases responsible for the different staining patterns. The results demonstrate the profound impact of glycosylation on immunohistochemistry. Among carbohydrate epitopes, sialyl-TF, sialyl-Le(x), sialyl-dimeric Le(x) and Tn were expressed on both columnar and basal cells (the s-TF3 isomer on columnar cells only). The carcinoma-associated Thomsen-Friedenreich epitope was absent.
UI - 11409019
AU - Hee CG; Perry CF
TI - Fine-needle aspiration cytology of parotid tumours: is it useful?
SO - ANZ J Surg 2001 Jun;71(6):345-8
AD - Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, QLD 4102, Australia. firstname.lastname@example.org
BACKGROUND: The efficacy of fine-needle aspiration cytology (FNAC) in the diagnosis of parotid tumours remains a controversial subject. Studies within small departments utilizing experienced pathologists have shown FNAC to have high sensitivity and specificity for parotid tumours. The present study was performed to assess the accuracy and utility of FNAC of parotid tumours within a teaching hospital environment. METHODS: One hundred and sixty-nine patients underwent both FNAC and subsequent surgery to the parotid between 1995 and 1999. The results of the FNAC were compared to the histopathological diagnosis obtained from the surgical specimen. RESULTS: Fine-needle aspiration cytology had an overall accuracy of 56%. Approximately 10% of the FNAC results were non-diagnostic. The sensitivity and specificity for the following diagnoses were, respectively: benign 86% and 61%; malignant 57% and 100%; pleomorphic adenoma 78% and 95%; squamous cell carcinoma 52% and 99%; mucoepidermoid carcinoma 14% and 99% and adenocarcinoma 20% and 100%. Six non-neoplastic conditions were misdiagnosed and all six patients underwent surgery. CONCLUSIONS: Fine-needle aspiration cytology was found to be highly specific for malignancy but its sensitivity for malignancy was poor. The results show that although FNAC is relatively inexpensive and minimally invasive, it cannot be relied upon to provide an accurate tissue diagnosis, may fail to identify malignancy and does not prevent patients undergoing surgery for non-neoplastic conditions.
UI - 11403256
AU - Schindler S; Nayar R; Dutra J; Bedrossian CW
TI - Diagnostic challenges in aspiration cytology of the salivary glands.
SO - Semin Diagn Pathol 2001 May;18(2):124-46
AD - Department of Pathology, Northwestern University Medical School, Chicago, IL, USA.
The main goal of fine-needle aspiration (FNA) of salivary gland lesions is to assist the clinician in the management of patients who present with a mass lesion. Cytologic examination aims to determine, if a process is inflammatory and/or reactive, benign or malignant neoplasm and if possible renders a specific diagnosis. It has been argued that in the area of salivary gland tumors, surgical management relies less heavily on a specific preoperative diagnosis, because almost all neoplastic salivary gland lesions will undergo surgical excision. However, knowing beforehand if a lesion is malignant or benign, will aid in planning surgery and may prompt or postpone decisions for surgical intervention. The salivary glands are unique in their histologic complexity and morphological variability of tumors, which is reflected in the cytologic material. In addition to the overlapping morphologic patterns of salivary gland tumors, they also represent relatively rare lesions, thus making it more difficult to acquire diagnostic expertise in FNA. Other than approaching salivary gland tumors by a description of single entities in their benign and malignant categories, we favor a more practical approach to diagnosis based on the key morphologic features noted in FNAs. This article addresses differential diagnoses according to the predominant cytologic presentation with attention to the cell type and size, nature of the cytoplasm, and the smear background.
UI - 11403257
AU - Tworek JA; Michael CW
TI - Parotid gland mucosa associated lymphomas and their cytologic mimics.
SO - Semin Diagn Pathol 2001 May;18(2):147-50
AD - Department of Pathology, Saint Joseph's Mercy Hospital, Ann Arbor, MI, USA.
Although the parotid is a target for myoepithelial sialadenitis and lymphomas of mucosa associated lymphoid tissue (MALTomas), MALTomas are rare and have not been well characterized in the cytology literature. We examine fine needle aspiration biopsies from 19 lymphoid lesions of the parotid gland with particular emphasis on MALTomas and their cytologic look-a-likes. Purely on cytology it is difficult to distinguish with certainty a MALToma from a late-phase reactive lymph node. Both conditions were predominantly composed of small mature appearing lymphocytes and both occasionally had larger lymphocytes with tingible body macrophages. By contrast, the diagnosis of non-MALT lymphoma was usually straight forward, as they had overt cytologic atypia. In applying fine needle aspiration biopsy to large or persistent lymphoid lesions of extra-nodal sites like the parotid gland, we recommend the liberal use of flow cytometric analysis to distinguish between reactive lymph nodes and MALToma and to more precisely classify non-MALT lymphomas.
UI - 11419156
AU - Mortele B; Lemmerling M; Seynaeve P; Clarysse P; Quintens F; Kunnen M
TI - Hemangiopericytoma of the parotid gland: CT and MR features.
SO - Eur Radiol 2001;11(6):1073-5
AD - Department of Radiology, Gent University Hospital, De Pintelaan 185, 9000 Gent, Belgium.
Hemangiopericytomas are uncommon vascular neoplasms with rare occurrence in the head and neck region. They originate from the pericytes, which are small, oval cells encircling capillaries. Hemangiopericytomas traditionally appear in the retroperitoneum and in the capillaries of the extremities. A case of hemangiopericytoma of the parotid gland is presented. The clinical, surgical, histologic, and radiologic features are described and discussed.
UI - 11484973
AU - Ruiz-Godoy RL; Meneses GA; Mosqueda TA; Suarez RL
TI - Unusual salivary glands adenocarcinomas: a retrospective study.
SO - J Exp Clin Cancer Res 2001 Jun;20(2):189-94
AD - Division of Pathology, Instituto Nacional de Cancerologia, Universidad Autonoma Metropolitana Xochimilco, Mexico. email@example.com
Malignant tumors of the salivary gland ducts exhibit variable morphological patterns and biological behavior. This group of neoplasms includes some uncommon lesions that originate from the intercalated ducts, such as polymorphous low-grade adenocarcinoma, epithelial-myoepithelial carcinoma and basal cell adenocarcinoma, and other that arise from the excretory duct, such as the salivary duct carcinoma. One hundred and seventy-seven malignant neoplasms of the major and minor salivary glands were reviewed. There were 23 cases of uncommon types of ductal carcinomas. Age, sex, location, size of tumor were examined as well as their histopathological features. There were four polymorphous low-grade adenocarcinomas (17.3%), two of which were located on the palate and two on the cheek; seven epithelial-myoepithelial carcinomas (30.4%), most of them located in the parotid; six basal cell adenocarcinomas (26%) which predominated in the submandibular gland, and there were six salivary duct carcinomas (26%), four of which occurred in the parotid gland, and two in the submandibular gland.
UI - 11489377
AU - Furukawa M; Suzuki H; Matsuura K; Takahashi E; Suzuki H; Tezuka F
TI - Carcinoma ex pleomorphic adenoma of the palatal minor salivary gland with extension into the nasopharynx.
SO - Auris Nasus Larynx 2001 Aug;28(3):279-81
AD - Department of Otorhinolaryngology, Sendai National Hospital, 2-8-8 Miyagino Miyagino-ku, Sendai 983-8520, Japan. firstname.lastname@example.org
Carcinoma ex pleomorphic adenoma presenting in the nasopharynx is extremely rare. We present a case of carcinoma ex pleomorphic adenoma occupying the nasopharynx and the soft palate in a 51-year-old woman. To the best of our knowledge, this is the first reported case of carcinoma ex pleomorphic adenoma in the nasopharynx.
UI - 11489378
AU - Sato J; Himi T; Matsui T
TI - Parasympathetic schwannoma of the submandibular gland.
SO - Auris Nasus Larynx 2001 Aug;28(3):283-5
AD - Department of Otolaryngology, Sapporo Medical University, School of Medicine, S-1W-16 Chuo-ku, Sapporo 060-8543, Japan. email@example.com
Schwannomas of the submandibular gland have only been documented sporadically throughout the medical literature. We describe a case of schwannoma of the submandibular gland originating from the submandibular branch of the lingual nerve, which carries the preganglionic parasympathetic nerve fibers. The clinical aspect of this tumor is discussed, followed by a brief literature review.
UI - 11036244
AU - Economopoulou P; Hanby A; Odell EW
TI - Expression of E-cadherin, cellular differentiation and polarity in epithelial salivary neoplasms.
SO - Oral Oncol 2000 Nov;36(6):515-8
AD - Head and Neck Cancer Research Programme, Division of Oral Medicine and Pathology, King's College London Dental Institute, Floor 28 Guy's Tower, Guy's Hospital, SE1 9RT, London, UK.
To investigate whether expression of E-cadherin correlates with polarised tissue organisation, grade or tumour type in salivary neoplasms, frozen sections from 30 salivary gland neoplasms were stained immunohistochemically for E-cadherin using the antibody HECD-1 and compared to the staining patterns in five samples of normal salivary gland. Lesions with areas of lack of staining were restained at two higher antibody concentrations. Normal salivary gland stained strongly around the periphery of acinar and ductal cells. Neoplasms mostly stained strongly regardless of neoplasm type. Reproducible loss of expression was found only in epithelial cells showing stromal or plasmacytoid (hyaline) differentiation in pleomorphic adenoma. Low- and high- grade mucoepidermoid carcinomas, adenocarcinoma NOS and carcinoma ex pleomorphic adenoma showed focal loss of expression but this was not related to tissue architecture, differentiation or invasiveness. We conclude that the relationship seen between E-cadherin expression and cell polarity/glandular organisation in breast and colon does not appear to exist for salivary gland neoplasms in which the diversity of architectural patterns precludes detection of any simple relationship. E-cadherin expression seems unlikely to be a useful marker for diagnosis or prognosis in salivary neoplasia in general.
UI - 11337269
AU - Machado de Sousa SO; Soares de Araujo N; Correa L; Pires Soubhia AM;
TI - Cavalcanti de Araujo V Immunohistochemical aspects of basal cell adenoma and canalicular adenoma of salivary glands.
SO - Oral Oncol 2001 Jun;37(4):365-8
AD - Department of Oral Pathology, School of Dentistry, University of Sao Paulo, Av. Prof. Lineu Prestes 2227, 05508-900, Sao Paulo, SP, Brazil. firstname.lastname@example.org
Basal cell adenoma is a benign epithelial neoplasm with a uniform histologic appearance dominated by basaloid cells. Those cells may be distributed in various arrangements as solid, trabecular, tubular and membranous. Canalicular adenoma is also a benign neoplasm composed by columnar cells arranged in branching and interconnecting cords of single or double cell thick rows. There is some disagreement among investigators about whether canalicular adenoma should be included within the basal cell adenoma histologic spectrum. In the present study we compared the expression of cytokeratins (CK), vimentin and muscle-specific actin, utilizing immunohistochemical technique, in three cases diagnosed as basal cell adenomas predominantly of the solid type, and three cases of canalicular adenomas. The results obtained showed a distinct immunoprofile for both neoplasms. Solid areas of basal cell adenomas did not stain for any of the tested antibodies; only when there was tubular differentiation, those structures expressed CKs 7, 8, 14, and 19 in luminal cells and vimentin in non-luminal cells. On the other hand, canalicular adenomas strongly expressed CKs 7 and 13. The panel of antibodies utilized supports the separation of the two entities.
UI - 11527159
AU - Esposito C; Zupi A; Califano L
TI - Surgical therapy of parotid hemangiomas.
SO - Pediatr Surg Int 2001 Jul;17(5-6):335-7
AD - Department of Pediatric Surgery, School of Medicine and Surgery, Federico II University of Naples, Italy.
The goal of this review is to define the clinical characteristics of parotid hemangiomas in children and outline their therapeutic management. The records of 42 pediatric patients with hemangiomas were reviewed; 10 required surgical treatment. Two cases of temporary postoperative facial nerve palsy were observed. Treatment was commonly delayed, and there is a significant likelihood of spontaneous regression. The indications for surgical intervention are an increase in tumor size, rapid tumor growth, failure of tumor size to decrease and hemorrhage into the lesion.
UI - 11555161
AU - Franchi A; Moroni M; Paglierani M; Santucci M
TI - Expression of CD44 standard and variant isoforms in parotid gland and parotid gland tumours.
SO - J Oral Pathol Med 2001 Oct;30(9):564-8
AD - Department of Human Pathology and Oncology, University of Florence Medical School, Viale G.B. Morgagni 85, 50134 Florence, Italy.
In this study, we investigated the distribution of the standard form of the CD44 (CD44s) cell adhesion molecule and of its v3 and v6 isoforms in samples of foetal and adult parotid gland tissue, in comparison with samples of parotid gland adenomas and carcinoma ex pleomorphic adenoma. Foetal parotid gland showed CD44s and CD44v3 expression in the peripheral small primordial ducts and acini, while CD44v6 was only focally expressed. Adult parotid gland tissue showed a similar distribution of CD44s and variants, with a predominant expression in acinar structures and a weaker expression at duct level. In parotid gland adenomas, a diffuse and intense expression of CD44s and variants 3 and 6 was observed only in pleomorphic adenomas, while expression of CD44s was prevalent in Warthin's tumour, myoepithelioma and oncocytoma. The malignant areas of carcinoma ex pleomorphic adenoma showed a markedly decreased expression of CD44v3 and CD44v6 in comparison with the adjacent pleomorphic adenoma component. In conclusion, the prevalent expression of CD44s and variants in pleomorphic adenoma in comparison with other adenomas may be related to the abundant extracellular matrix production present in these tumours, while loss of CD44v3 and CD44v6 associated with the onset of carcinoma ex pleomorphic adenoma could promote stromal invasion, eventually contributing to the development of distant metastases.
UI - 11555785
AU - Jaehne M; Jakel KT; Roser K; Ussmuller J; Loning T
TI - [About the prognostic value of Her-2 gene-amplification and cell-proliferation in salivary duct carcinoma of the major salivary glands - a pilot-study]
SO - Laryngorhinootologie 2001 Sep;80(9):525-9
AD - Klinik und Poliklinik fur Hals-Nasen-Ohrenheilkunde, Universitatsklinikum Hamburg-Eppendorf, Germany. email@example.com
INTRODUCTION: The salivary duct carcinoma (sdc) represents a rare variant of the group of adeno-carcinomas of the salivary glands. Histopathologically, it is marked by solid and cribriform cell nests with central necrosis, displaying distinct similarity with the ductal carcinoma of the breast, where prognosis can be correlated with Her-2 gene-amplification. Based on this histopathological similarity, the prognostic value of Her-2 gene amplification in SDC was examined in the presented pilot-study. PATIENTS AND METHODS: Four own patients with different clinical courses were examined in regard to their histopathological features, Her-2 gene-amplification and proliferation (Ki67). RESULTS: Three of the four patients died tumor related 2.4, 5.5 and 8.2 years after initial diagnosis. The remaining patient died tumor-free 6 year after diagnosis (myocardial infarct). The two patients with an early recurrent disease and distant metastasis showed a high Her-2 expression and proliferation (Ki67), compared to the other two patients. CONCLUSION: In the presented pilot-study a distinct correlation between Her2-gene-amplification, proliferation (Ki67) and clinical course could be observed. Additional analysis to evaluate this aspect seems rectified, especially under recognition of therapy decisions.
UI - 11562768
AU - Hoang MP; Callender DL; Sola Gallego JJ; Huang Z; Sneige N; Luna MA;
TI - Batsakis JG; El-Naggar AK Molecular and biomarker analyses of salivary duct carcinomas: comparison with mammary duct carcinoma.
SO - Int J Oncol 2001 Oct;19(4):865-71
AD - Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Salivary duct carcinoma (SDC) is a rare high-grade aggressive neoplasm that manifests close histologic features with invasive ductal carcinoma of the breast (IDC). In contrast to SDC, extensive molecular studies have been performed on IDC and led to the identification of certain biological markers. To investigate the underlying molecular and biologic characteristics of SDC, we performed molecular analyses using microsatellite markers on chromosomal arms 6q, 16q, 17p, and 17q, DNA flow cytometry and immunohistochemical staining for androgen receptor (AR) and p53 expression on 28 examples of these tumors in comparison to 24 IDC cases. Our results show that generally similar allelic alterations, elevated p53 and androgen receptor expressions, and high frequency of DNA aneuploidy are manifested in both SDCs and IDCs. Differences at certain markers on 6q, 17p and 17q chromosomal loci, however, were observed between the two entities. Certain loci on 6q were more frequently altered in SDC than IDC which loci on chromosomes 17p and q arms were more seen in IDCs than SDCs. The majority of SDCs had high AR expression while most of IDCs were AR negative. Our study indicates that: i) SDC may share some genetic alterations with IDC, ii) high AR expression in SDC may play a role in tumor progression, and iii) p53 overexpression and DNA aneuploidy in both entities reflect their aggressive behavior.
UI - 11572247
AU - Carinci F; Farina A; Pelucchi S; Calearo C; Pastore A
TI - Parotid gland carcinoma: surgical strategy based on local risk factors.
SO - J Craniofac Surg 2001 Sep;12(5):434-7
AD - Chair of Maxillofacial Surgery, University of Ferrara, Italy. firstname.lastname@example.org
To evaluate the best surgical strategy in cases of parotid gland carcinoma, local risk factors (T, N, histology, and treatment) were analyzed in a series of 134 patients. The efficacy of the facial nerve sacrifice in case of macroscopic tumor infiltration was tested by means of survival analyses (Kaplan-Meier and Cox algorithms). This study demonstrated that nerve preservation resulted in a better prognostic value when compared with resection only in the group of patients having a T1 or T2. In patients affected by T3 and T4, the different treatment did not show any difference in survival rate. In conclusion, the sacrifice of the facial nerve is not always able to improve the survival rate.
UI - 11570911
AU - Khurana KK; Mortelliti AJ
TI - The role of fine-needle aspiration biopsy in the diagnosis and management of juvenile hemangioma of the parotid gland and cheek.
SO - Arch Pathol Lab Med 2001 Oct;125(10):1340-3
AD - Department of Pathology, SUNY Upstate Medical University Hospital, Syracuse, NY 13210, USA. Khuranak@upstate.edu
BACKGROUND: The current recommendation for the management of juvenile hemangiomas (JH) is to delay treatment in the hope of spontaneous regression. However, accurate diagnosis is necessary before considering conservative management. Traditionally, the diagnosis of JH has required excisional biopsy. The cytology literature on this relatively rare neoplasm is sparse. OBJECTIVE: To present our experience with fine-needle aspiration in the diagnosis and management of JH. DESIGN: Three cases with a cytologic diagnosis consistent with JH of the parotid gland and cheek were identified from our cytopathology files. Aspirate smears, immunohistochemical studies, computed tomographic scan findings, and clinical follow-up were reviewed. RESULTS: Patients were female infants ranging in age from 3 to 9 months and presented with an oval firm mass (size range, 2.0-5.0 cm) involving the parotid gland (2 cases) and cheek (1 case). Computed tomographic scan with contrast demonstrated homogeneous enhancement. Aspirate smears revealed spindle-shaped cells in sheets and clusters in a background of blood. The parotid gland aspirates and cell block preparations revealed ductal structures entrapped in sheets of spindle-shaped cells. Immunohistochemical studies revealed prominent vascular spaces lined by CD34 and factor VIII-positive flattened endothelial cells. The diagnosis of JH was rendered on the basis of the cytologic findings in conjunction with the radiologic and clinical findings. On clinical follow-up (8-24 months), none of the patients has shown any progression of the lesion. CONCLUSIONS: Fine-needle aspiration, in conjunction with imaging studies, is a useful tool in the diagnosis and management of JH. It eliminates the need for surgical excision for diagnostic purposes and allows for clinical follow-up of patients with JH.
UI - 11590073
AU - Franca CM; Jaeger RG; Freitas VM; Araujo NS; Jaeger MM
TI - Effect of N-CAM on in vitro invasion of human adenoid cystic carcinoma cells.
SO - Oral Oncol 2001 Dec;37(8):638-42
AD - Universidade de Sao Paulo, Faculdade de Odontologia, Disciplina de Patologia Bucal, Av. Prof. Lineu Prestes, 2227, 05508-900 Sao Paulo-SP, Brazil.
Adenoid cystic carcinoma of salivary glands is characterised by aggressive behaviour, high rate of local recurrences, neurotropism and late metastasis. In a previous work we demonstrated that adenoid cystic carcinoma cultured cells (CAC2 cells) expressed N-CAM. It was suggested that this expression, modulated by extracellular matrix, would be correlated to cell movement. The aim of our study was to verify whether CAC2 cells presented invasion capacity. Moreover, we tested whether the neural adhesion molecule (N-CAM) would participate in this process. CAC2 cells were either previously treated, or not (control), with a monoclonal antibody against N-CAM. Invasion assays were carried out using a modified Boyden chamber (Transwell chamber). CAC2 cells (10(5)) were dispensed into Transwell upper chamber on the top of Matrigel coated filter. The cells that invaded the filters in the first 8 h were counted under light microscopy, yielding data for the invasion rates (%). Control CAC2 cells presented an invasion rate of 5.28+/-0.04%. The invasion rate raised to 6.53+/-0.2% when N-CAM was blocked with monoclonal antibody. N-CAM impaired the adenoid cystic carcinoma cell invasion in vitro. Therefore, we suggest an anti-invasive role for N-CAM in adenoid cystic carcinoma.
UI - 11593192
AU - Pirodda A; Ferri GG; Truzzi M; Cavicchi O
TI - Benign cystic teratoma of the parotid gland.
SO - Otolaryngol Head Neck Surg 2001 Oct;125(4):429-30
AD - Department of Surgical and Anaesthesiological Sciences, ENT Section, University of Bologna, S. Orsola Hospital, via Massarenti 9, 40138 Bologna, Italy.
UI - 11605225
AU - Shinohara S; Yamamoto E; Tanabe M; Maetani T; Fujiwara K; Kim T
TI - [Evaluation of RI scintiscanning to parotid gland tumors]
SO - Nippon Jibiinkoka Gakkai Kaiho 2001 Sep;104(9):852-8
AD - Department of Otolaryngology, Kobe City General Hospital, Kobe.
We retrospectively evaluated preoperative radioisotope (RI) scintiscans in 275 patients (283 glands) with parotid tumors who undergoing surgery between 1987 and 2000. Technetium-99m-pertechnetate (Tc) scintigraphy was conducted on 201 glands. Oncocytoma and Warthin's tumor showed a high positive rate. In evaluating Warthin's tumor with Tc scintigraphy, sensitivity was 75% and specificity 88%; above the age of 40 years, specificity exceeded 90%. Gallium-67-citrate (Ga) scintigraphy was conducted on 207 glands. Malignant parotid tumors showed high positivity (85%), but the specificity of positive findings was quite low (38%) because 44% of benign pleomorphic adenoma, which occupied major material, showed Ga-positive findings. Ga-negative findings indicated high probability (95%) of benign tumors. Thus, Tc scintigraphy is effective in diagnosing Warthin's tumor, while Ga scintigraphy is effective in diagnosing benign tumors.
UI - 11598171
AU - Okabe M; Inagaki H; Murase T; Inoue M; Nagai N; Eimoto T
TI - Prognostic significance of p27 and Ki-67 expression in mucoepidermoid carcinoma of the intraoral minor salivary gland.
SO - Mod Pathol 2001 Oct;14(10):1008-14
AD - Department of Pathology, Nagoya City University Medical School, Nagoya, Japan.
p27 and Ki-67, a universal cyclin-dependent kinase inhibitor and a proliferative cell marker, respectively, have been useful in predicting clinical aggressiveness in various human tumors. We studied clinicopathologic significance of these molecules in mucoepidermoid carcinoma of the intraoral minor salivary gland. Expression of p27 and Ki-67 was assessed immunohistochemically in primary mucoepidermoid carcinomas from 31 patients without distant metastasis at surgery. Correlation each of p27 and Ki-67 expression was analyzed with various clinicopathologic parameters including age, sex, primary tumor site, tumor size, nodal metastasis, clinical stage, and histologic grade. The latter was evaluated using a point-scoring scheme of Auclair et al. that consists of five histologic factors (intracystic component, neural invasion, necrosis, mitosis, and anaplasia). p27 expression was correlated inversely with histologic grade (P =.007), but with none of other factors. When the correlation of p27 expression was further examined with each of the histologic factors, it was correlated significantly with intracystic component, but not with neural invasion, necrosis, mitosis, or anaplasia. Ki-67 expression was correlated significantly with histologic grade only in the clinicopathologic factors (P <.0001), and in the histologic factors, with necrosis, mitosis, and anaplasia. Multivariate prognostic analyses were performed to identify independent risk factors for both disease-free and overall survivals. Large tumor size (P =.031, relative risk = 5.5) and low p27 expression (P =.012, relative risk = 5.2) were risk factors for worse disease-free survival. Low p27 expression (P =.015, relative risk = 15.2) was selected as a risk factor for worse overall survival. Other factors including age, sex, tumor site, nodal status, clinical stage, histologic grade, and Ki-67 did not emerge as independent risk factors in either prognostic analysis. These data suggest that p27 may be useful in estimating prognosis of the patients who have mucoepidermoid carcinoma of the intraoral minor salivary gland.
UI - 11678950
AU - Teymoortash A; Lippert BM; Werner JA
TI - Steroid hormone receptors in parotid gland cystadenolymphoma (Warthin's tumour).
SO - Clin Otolaryngol 2001 Oct;26(5):411-6
AD - Department of Otolaryngology, Head and Neck Surgery, Philipps University, Marburg, Germany. email@example.com
The aetiopathogenesis of cystadenolymphoma is mostly unknown. Cystadenolymphomas have a significantly higher incidence in the male than the female population. This might be as a result of endocrine dependency in this kind of tumour. The purpose of the present study was to determine the sex hormone receptor status in cystadenolymphoma. Tissue samples of cystadenolymphoma, pleomorphic adenoma and normal samples of the parotid gland were examined immunohistochemically for oestrogen and progesterone receptors. Progesterone-positive cells could be found in the salivary duct system of normal glands and in the epithelial components of cystadenolymphomas. There was no evidence for the presence of oestrogen receptor in any sample studied. The evidence of progesterone receptors in cystadenolymphoma may implicate a potential role of endocrine factors in the development of this tumour.
UI - 11683932
AU - Fornelli A; Eusebi V; Pasquinelli G; Quattrone P; Rosai J
TI - Merkel cell carcinoma of the parotid gland associated with Warthin tumour: report of two cases.
SO - Histopathology 2001 Oct;39(4):342-6
AD - Dipartimento di Oncologia, Sezione di Anatomia Istologia e Citologia Patologica della Universita di Bologna, Bologna, Italy.
AIMS: Two cases of Merkel cell carcinoma occurring simultaneously and in close association with a Warthin tumour of the parotid gland are reported. METHODS AND RESULTS: The patients were a 65-year-old man and a 70-year-old man, respectively. The Merkel cell carcinoma component was immunoreactive for chromogranin and keratin 20 and contained neuroendocrine-type granules at the ultrastructural level. CONCLUSIONS: The histogenesis of this heretofore undescribed combination is discussed.
UI - 11683933
AU - Schwerer MJ; Kraft K; Baczako K; Maier H
TI - Cytokeratin expression and epithelial differentiation in Warthin's tumour and its metaplastic (infarcted) variant.
SO - Histopathology 2001 Oct;39(4):347-52
AD - Department of Pathology, Military Hospital Ulm, Ulm/Donau, Germany.
AIMS: Warthin's tumour is characterized by a bilayered columnar epithelium. Transformation into metaplastic (infarcted) Warthin's tumour includes squamous metaplasia of the epithelium along with regressive changes in the stroma. Misinterpretation of metaplastic Warthin's tumour for malignancy is a serious diagnostic pitfall. This study assesses the utility of cytokeratin expression in Warthin's tumour and its metaplastic variant. METHODS AND RESULTS: Twenty-six cases of Warthin's tumour, among them eight metaplastic Warthin's tumours, were investigated employing immunohistochemistry. Both Warthin's tumour and its metaplastic variant regularly expressed cytokeratins (CK) 7, 8, 18, and 19. Staining results with antibodies to CK10, 10/13, 1/2/10/11, and 20 were negative in all specimens. Immunoreactivity for CK 5/14 and 17 was restricted to basal cells in Warthin's tumour, but involved basal as well as surface cells in metaplastic Warthin's tumour. CONCLUSIONS: Warthin's tumour and its metaplastic (infarcted) variant both express CK 7, 8, 18, and 19, which are typical for columnar differentiation. Cytokeratins typical of squamous differentiation are absent from Warthin's tumour and its metaplastic variant, irrespective of the squamous morphology of the epithelium in metaplastic Warthin's tumour. The expression of CK 5/14 and 17, which are typical of regenerative cells, is restricted to basal cells in Warthin's tumour, but is expressed also in surface cells in metaplastic Warthin's tumour.
UI - 11692423
AU - Almela Cortes R; Faubel Serra M; Cueva Ruiz C; Conde Perez de la Blanca
TI - I [Intra-parotid facial plexiform neurofibroma. Review of the literature]
SO - An Otorrinolaringol Ibero Am 2001;28(4):363-70
AD - Servicio de ORL, Hospital General de Especialidades Ciudad de Jaen, Jaen.
It is being tumor developed from Schwann cells of peripheral nerves sheath. In its plexiform type it is a rare growth presenting solitary or in the context of von Recklinghausen's disease. The aim of this article is to present one plexiform neurofibroma localized in the parotid gland. At the same time we make a perusal on the literature of this kind of tumor.
UI - 11688044
AU - Siciliano S; Crevecoeur H; Weynand B; Reychler H
TI - Primary neuroendocrine carcinoma of the parotid gland: a case report.
SO - J Oral Maxillofac Surg 2001 Nov;59(11):1359-62
AD - University Hospital St. Luc, Catholic University of Louvain, Brussels, Belgium. Siciliano@stom.ucl.ac.be
UI - 11710645
AU - de Oliveira PT; Jaeger MM; Miyagi SP; Jaeger RG
TI - The effect of a reconstituted basement membrane (matrigel) on a human salivary gland myoepithelioma cell line.
SO - Virchows Arch 2001 Oct;439(4):571-8
AD - Department of Oral Pathology, School of Dentistry, University of Sao Paulo, SP, Brazil.
We have already demonstrated that a reconstituted basement membrane (Matrigel) is a key modulator of morphogenetic changes and cytodifferentiation of pleomorphic adenoma cells in culture. Myoepithelioma is considered to be a neoplasm closely related to pleomorphic adenoma and should experience similar induction processes. Thus, the aim of this study was to investigate whether Matrigel would influence myoepithelioma cells. We used a cell line derived from a human salivary gland plasmacytoid myoepithelioma (M1 cells) grown in a three-dimensional preparation of Matrigel. Phenotype differences were assessed using conventional light microscopy technique (haematoxylin and eosin) and phase and differential interference contrast (Nomarski). Immunofluorescence was carried out to detect smooth-muscle actin, laminin and type-IV collagen. M1 cells exhibited all proteins studied, showing a myoepithelial differentiation. M1 cells grown inside Matrigel presented morphological changes and changes in smooth-muscle actin status. By growing M1 cells inside Matrigel, it was possible to reproduce the tumour architecture with no duct-like structures. Based on our findings, we suggest that myoepithelioma would be derived from a cell with a commitment to myoepithelial differentiation. We also suggest that the mechanical properties of the matrix environment will likely regulate smooth-muscle actin expression in myoepithelioma.
UI - 11710649
AU - Jaehne M; Jakel KT; Ussmuller J; Feller AC
TI - Nasal NK/T-cell-lymphoma metastazising into the masseteric muscle mimicking a parotid mass.
SO - Virchows Arch 2001 Oct;439(4):597-8
UI - 11704316
AU - Storey MR; Garden AS; Morrison WH; Eicher SA; Schechter NR; Ang KK
TI - Postoperative radiotherapy for malignant tumors of the submandibular gland.
SO - Int J Radiat Oncol Biol Phys 2001 Nov 15;51(4):952-8
AD - Department of Radiation Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.
PURPOSE: This retrospective study assessed the outcome and patterns of failure for patients with malignant submandibular tumors treated with surgery and postoperative radiation. METHODS AND MATERIALS: Between 1965 and 1995, 83 patients aged 11-83 years old received postoperative radiotherapy after resection of submandibular gland carcinomas. The most common radiation technique was an appositional field to the submandibular gland bed using electrons either alone or mixed with photons. Primary tumor bed doses ranged from 50 to 69 Gy (median, 60 Gy). Regional lymph nodes (ipsilateral Levels I-IV) were irradiated in 66 patients to a median dose of 50 Gy. Follow-up time ranged from 5 to 321 months (median, 82 months). RESULTS: Actuarial locoregional control rates were 90%, 88%, and 88% at 2, 5, and 10 years, respectively. The corresponding disease-free survival rates were 76%, 60%, and 53%, because 27 of 74 patients (36%) who attained locoregional control developed distant metastases. Adenocarcinoma, high-grade histology, and treatment during the earlier years of the study were associated with worse locoregional control and disease-free survival. The median survival times for patients with and without locoregional control were 183 months and 19 months, respectively. Actuarial 2-, 5-, and 10-year survival rates were 84%, 71%, and 55%, respectively. Late complications occurred in 8 patients (osteoradionecrosis, 5 patients). CONCLUSIONS: High-risk cancers of the submandibular gland have a historic control rate of approximately 50% when treated with surgery alone. In the current series, locoregional control rates for high-risk patients with submandibular gland cancers treated with surgery and postoperative radiotherapy were excellent, with an actuarial locoregional control rate of 88% at 10 years.
UI - 11715527
AU - Wang J; Dong F; Yong P
TI - [Tumour suppressor p53 gene sequence mutations in pleomorphic adenoma of salivary gland]
SO - Zhonghua Yi Xue Za Zhi 1999 Oct;79(10):777-9
AD - School of Stomatology, Hebei Medical University, Shijiazhuang 050017.
OBJECTIVE: To detect p53 exon 7 and 8 mutation and to study genesis and biological characteristics of pleomorphic adenoma of salivary galand. METHODS: Polymerase chain reaction- single-strand conformational polymorphism (PCR-SSCP) and DNA sequencing analysis were used. RESULTS: PCR-SSCP analysis showed that in 11 patients with positive SSCP, 7 showed abnormal exon 7 and 3 abnormal exon 8. Comparison of SSCP results with DNA sequencing showed that patients all patients with p53 exon 7 and 8 mutations were SSCP positive. Exon 7 mutation pattern was point mutation(T-->C). Exon 8 mutation pattern included base substitution (point mutation) (C-->A) and frame-shiftmutation (base insertion and base loss). CONCLUSIONS: Polycodon and poly-pattern mutations appeared in p53 exon 7 and 8. Pleomorphic adenoma of salivary galand was similar to malignant tumor in p53 gene mutation. Poly-codon mutation could occur in the same case.
UI - 11718383
AU - Browne RF; Golding SJ; Watt-Smith SR
TI - The role of MRI in facial swelling due to presumed salivary gland disease.
SO - Br J Radiol 2001 Feb;74(878):127-33
AD - Department of Radiology, University of Oxford, John Radcliffe Hospital, Headington, UK.
50 consecutive patients presenting with facial swelling thought clinically to be due to salivary gland disease underwent MRI. Examinations were interpreted by one radiologist without access to previous investigations. Records were reviewed to determine the reliability and role of MRI in patient management, and the contribution of other prior or subsequent investigations. MRI findings were verified against operative findings, percutaneous biopsy or clinical follow-up (periods ranging from 8-58 months). A mass was found in 27 patients; in 11 of these patients, disease was extrinsic to the salivary gland. MRI diagnosis of tumour was correct in all patients and MRI was a reliable investigation for planning surgical resection. No mass was found in 23 patients, 8 of whom had normal appearan
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