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Table of Contents
1
UI - 11014666
AU - Miliauskas JR; Orell SR
TI -
Acinic cell carcinoma arising in pleomorphic adenoma of parotid gland.
SO - Cytopathology 2000 Oct;11(5):356-9
2
UI - 11370765
AU - Chen CH; Li BY; Wan JT; Sun A; Leu JS; Chiang CP
TI -
Expression of epidermal growth factor in salivary adenoid cystic
carcinoma.
SO - Proc Natl Sci Counc Repub China B 2001 Apr;25(2):90-6
AD - Department of Dentistry, School of Dentistry, China Medical College,
Taichung, Taiwan, ROC.
This study used an immunohistochemical technique to assess the
expression of epidermal growth factor (EGF) in 40 specimens of salivary
adenoid cystic carcinoma (ACC), 7 specimens of labial glands adjacent to
mucocele, and 5 specimens of normal submandibular glands. In normal
submandibular glands, immunohistochemically detectable EGF was
demonstrated in all ductal segments, including intercalated, striated,
and excretory duct cells. No EGF positive staining was found in acinar
compartments. including serous and mucous acinar cells. In degenerated
labial glands adjacent to mucocele, no EGF staining was detected in the
remaining acinar and ductal cells. In salivary ACCs, positive EGF
immunostaining was observed in one of the 5 (20%) ACCs with a solid
pattern and in 13 of the 35 (37.1%) ACCs with a tubular-cribriform
pattern. The overall EGF expression rate in 40 salivary ACCs was 35%.
Positive EGF staining was predominantly found in tubular structures in
the tubular ACCs and in duct-like structures in large cribriform
patterns or in the stroma of the cribriform ACCs. There was no
significant correlation between EGF expression in salivary ACCs and any
of the clinicopathological parameters including patient age and sex,
cancer location, TNM status, clinical stage, histologic type,
perivascular or perineural invasion, focal necrosis of tumor, and
cellular atypia. We conclude that the duct segments of the normal
submandibular gland are the sites of EGF synthesis and secretion. In
degenerated labial glands adjacent to mucocele, EGF synthesis is
completely inhibited. Furthermore, EGF is mainly biosynthesized in cells
forming tubular or duct-like structures in tubular or cribriform
salivary ACCs, and EGF may play a biologic role, particularly as a
mitogen in salivary ACC growth.
3
UI - 11405064
AU - Cao Y; Karsten U
TI -
Binding patterns of 51 monoclonal antibodies to peptide and carbohydrate
epitopes of the epithelial mucin (MUC1) on tissue sections of
adenolymphomas of the parotid (Warthin's tumours): role of epitope
masking by glycans.
SO - Histochem Cell Biol 2001 Apr;115(4):349-56
AD - Max Delbruck Centre for Molecular Medicine, R.-Rossle-Strasse 10, 13125
Berlin-Buch, Germany.
Warthin's tumours provide a unique opportunity to distinguish and
compare monoclonal antibodies (mAbs) to the epithelial mucin, MUC1. In
this study, we have applied the range of anti-MUC1 antibodies submitted
to the ISOBM TD-4 Workshop for this purpose. mAbs and lectins against
MUC1-associated carbohydrate epitopes were also included. Among 39 mAbs
to peptide epitopes of MUC1, eight distinct types of staining patterns
towards the two epithelial cell layers of Warthin's tumours could be
observed. A majority of 27 mAbs reacted preferentially (17) or
exclusively (10) with columnar cells, whereas 10 mAbs favoured basal
cells (1 of them almost exclusively). The observed staining patterns
revealed no correlation with the epitopes. However, after
carbohydrate-specific periodate oxidation, 33 of the mAbs stained
columnar and basal cells equally well, indicating that epitope masking
by glycan side chains was in most cases responsible for the different
staining patterns. The results demonstrate the profound impact of
glycosylation on immunohistochemistry. Among carbohydrate epitopes,
sialyl-TF, sialyl-Le(x), sialyl-dimeric Le(x) and Tn were expressed on
both columnar and basal cells (the s-TF3 isomer on columnar cells only).
The carcinoma-associated Thomsen-Friedenreich epitope was absent.
4
UI - 11409019
AU - Hee CG; Perry CF
TI -
Fine-needle aspiration cytology of parotid tumours: is it useful?
SO - ANZ J Surg 2001 Jun;71(6):345-8
AD - Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra
Hospital, Ipswich Road, Woolloongabba, QLD 4102, Australia.
cquehee@mydesk.net.au
BACKGROUND: The efficacy of fine-needle aspiration cytology (FNAC) in
the diagnosis of parotid tumours remains a controversial subject.
Studies within small departments utilizing experienced pathologists have
shown FNAC to have high sensitivity and specificity for parotid tumours.
The present study was performed to assess the accuracy and utility of
FNAC of parotid tumours within a teaching hospital environment. METHODS:
One hundred and sixty-nine patients underwent both FNAC and subsequent
surgery to the parotid between 1995 and 1999. The results of the FNAC
were compared to the histopathological diagnosis obtained from the
surgical specimen. RESULTS: Fine-needle aspiration cytology had an
overall accuracy of 56%. Approximately 10% of the FNAC results were
non-diagnostic. The sensitivity and specificity for the following
diagnoses were, respectively: benign 86% and 61%; malignant 57% and
100%; pleomorphic adenoma 78% and 95%; squamous cell carcinoma 52% and
99%; mucoepidermoid carcinoma 14% and 99% and adenocarcinoma 20% and
100%. Six non-neoplastic conditions were misdiagnosed and all six
patients underwent surgery. CONCLUSIONS: Fine-needle aspiration cytology
was found to be highly specific for malignancy but its sensitivity for
malignancy was poor. The results show that although FNAC is relatively
inexpensive and minimally invasive, it cannot be relied upon to provide
an accurate tissue diagnosis, may fail to identify malignancy and does
not prevent patients undergoing surgery for non-neoplastic conditions.
5
UI - 11403256
AU - Schindler S; Nayar R; Dutra J; Bedrossian CW
TI -
Diagnostic challenges in aspiration cytology of the salivary glands.
SO - Semin Diagn Pathol 2001 May;18(2):124-46
AD - Department of Pathology, Northwestern University Medical School,
Chicago, IL, USA.
The main goal of fine-needle aspiration (FNA) of salivary gland lesions
is to assist the clinician in the management of patients who present
with a mass lesion. Cytologic examination aims to determine, if a
process is inflammatory and/or reactive, benign or malignant neoplasm
and if possible renders a specific diagnosis. It has been argued that in
the area of salivary gland tumors, surgical management relies less
heavily on a specific preoperative diagnosis, because almost all
neoplastic salivary gland lesions will undergo surgical excision.
However, knowing beforehand if a lesion is malignant or benign, will aid
in planning surgery and may prompt or postpone decisions for surgical
intervention. The salivary glands are unique in their histologic
complexity and morphological variability of tumors, which is reflected
in the cytologic material. In addition to the overlapping morphologic
patterns of salivary gland tumors, they also represent relatively rare
lesions, thus making it more difficult to acquire diagnostic expertise
in FNA. Other than approaching salivary gland tumors by a description of
single entities in their benign and malignant categories, we favor a
more practical approach to diagnosis based on the key morphologic
features noted in FNAs. This article addresses differential diagnoses
according to the predominant cytologic presentation with attention to
the cell type and size, nature of the cytoplasm, and the smear
background.
6
UI - 11403257
AU - Tworek JA; Michael CW
TI -
Parotid gland mucosa associated lymphomas and their cytologic mimics.
SO - Semin Diagn Pathol 2001 May;18(2):147-50
AD - Department of Pathology, Saint Joseph's Mercy Hospital, Ann Arbor, MI,
USA.
Although the parotid is a target for myoepithelial sialadenitis and
lymphomas of mucosa associated lymphoid tissue (MALTomas), MALTomas are
rare and have not been well characterized in the cytology literature. We
examine fine needle aspiration biopsies from 19 lymphoid lesions of the
parotid gland with particular emphasis on MALTomas and their cytologic
look-a-likes. Purely on cytology it is difficult to distinguish with
certainty a MALToma from a late-phase reactive lymph node. Both
conditions were predominantly composed of small mature appearing
lymphocytes and both occasionally had larger lymphocytes with tingible
body macrophages. By contrast, the diagnosis of non-MALT lymphoma was
usually straight forward, as they had overt cytologic atypia. In
applying fine needle aspiration biopsy to large or persistent lymphoid
lesions of extra-nodal sites like the parotid gland, we recommend the
liberal use of flow cytometric analysis to distinguish between reactive
lymph nodes and MALToma and to more precisely classify non-MALT
lymphomas.
7
UI - 11419156
AU - Mortele B; Lemmerling M; Seynaeve P; Clarysse P; Quintens F; Kunnen M
TI -
Hemangiopericytoma of the parotid gland: CT and MR features.
SO - Eur Radiol 2001;11(6):1073-5
AD - Department of Radiology, Gent University Hospital, De Pintelaan 185,
9000 Gent, Belgium.
Hemangiopericytomas are uncommon vascular neoplasms with rare occurrence
in the head and neck region. They originate from the pericytes, which
are small, oval cells encircling capillaries. Hemangiopericytomas
traditionally appear in the retroperitoneum and in the capillaries of
the extremities. A case of hemangiopericytoma of the parotid gland is
presented. The clinical, surgical, histologic, and radiologic features
are described and discussed.
8
UI - 11484973
AU - Ruiz-Godoy RL; Meneses GA; Mosqueda TA; Suarez RL
TI -
Unusual salivary glands adenocarcinomas: a retrospective study.
SO - J Exp Clin Cancer Res 2001 Jun;20(2):189-94
AD - Division of Pathology, Instituto Nacional de Cancerologia, Universidad
Autonoma Metropolitana Xochimilco, Mexico. lmgodoy@tutopia.com
Malignant tumors of the salivary gland ducts exhibit variable
morphological patterns and biological behavior. This group of neoplasms
includes some uncommon lesions that originate from the intercalated
ducts, such as polymorphous low-grade adenocarcinoma,
epithelial-myoepithelial carcinoma and basal cell adenocarcinoma, and
other that arise from the excretory duct, such as the salivary duct
carcinoma. One hundred and seventy-seven malignant neoplasms of the
major and minor salivary glands were reviewed. There were 23 cases of
uncommon types of ductal carcinomas. Age, sex, location, size of tumor
were examined as well as their histopathological features. There were
four polymorphous low-grade adenocarcinomas (17.3%), two of which were
located on the palate and two on the cheek; seven
epithelial-myoepithelial carcinomas (30.4%), most of them located in the
parotid; six basal cell adenocarcinomas (26%) which predominated in the
submandibular gland, and there were six salivary duct carcinomas (26%),
four of which occurred in the parotid gland, and two in the
submandibular gland.
9
UI - 11489377
AU - Furukawa M; Suzuki H; Matsuura K; Takahashi E; Suzuki H; Tezuka F
TI -
Carcinoma ex pleomorphic adenoma of the palatal minor salivary gland
with extension into the nasopharynx.
SO - Auris Nasus Larynx 2001 Aug;28(3):279-81
AD - Department of Otorhinolaryngology, Sendai National Hospital, 2-8-8
Miyagino Miyagino-ku, Sendai 983-8520, Japan. masa3003@ya2.so-net.ne.jp
Carcinoma ex pleomorphic adenoma presenting in the nasopharynx is
extremely rare. We present a case of carcinoma ex pleomorphic adenoma
occupying the nasopharynx and the soft palate in a 51-year-old woman. To
the best of our knowledge, this is the first reported case of carcinoma
ex pleomorphic adenoma in the nasopharynx.
10
UI - 11489378
AU - Sato J; Himi T; Matsui T
TI -
Parasympathetic schwannoma of the submandibular gland.
SO - Auris Nasus Larynx 2001 Aug;28(3):283-5
AD - Department of Otolaryngology, Sapporo Medical University, School of
Medicine, S-1W-16 Chuo-ku, Sapporo 060-8543, Japan. jsato@sapmed.ac.jp
Schwannomas of the submandibular gland have only been documented
sporadically throughout the medical literature. We describe a case of
schwannoma of the submandibular gland originating from the submandibular
branch of the lingual nerve, which carries the preganglionic
parasympathetic nerve fibers. The clinical aspect of this tumor is
discussed, followed by a brief literature review.
11
UI - 11036244
AU - Economopoulou P; Hanby A; Odell EW
TI -
Expression of E-cadherin, cellular differentiation and polarity in
epithelial salivary neoplasms.
SO - Oral Oncol 2000 Nov;36(6):515-8
AD - Head and Neck Cancer Research Programme, Division of Oral Medicine and
Pathology, King's College London Dental Institute, Floor 28 Guy's Tower,
Guy's Hospital, SE1 9RT, London, UK.
To investigate whether expression of E-cadherin correlates with
polarised tissue organisation, grade or tumour type in salivary
neoplasms, frozen sections from 30 salivary gland neoplasms were stained
immunohistochemically for E-cadherin using the antibody HECD-1 and
compared to the staining patterns in five samples of normal salivary
gland. Lesions with areas of lack of staining were restained at two
higher antibody concentrations. Normal salivary gland stained strongly
around the periphery of acinar and ductal cells. Neoplasms mostly
stained strongly regardless of neoplasm type. Reproducible loss of
expression was found only in epithelial cells showing stromal or
plasmacytoid (hyaline) differentiation in pleomorphic adenoma. Low- and
high- grade mucoepidermoid carcinomas, adenocarcinoma NOS and carcinoma
ex pleomorphic adenoma showed focal loss of expression but this was not
related to tissue architecture, differentiation or invasiveness. We
conclude that the relationship seen between E-cadherin expression and
cell polarity/glandular organisation in breast and colon does not appear
to exist for salivary gland neoplasms in which the diversity of
architectural patterns precludes detection of any simple relationship.
E-cadherin expression seems unlikely to be a useful marker for diagnosis
or prognosis in salivary neoplasia in general.
12
UI - 11337269
AU - Machado de Sousa SO; Soares de Araujo N; Correa L; Pires Soubhia AM;
TI -
Cavalcanti de Araujo V
Immunohistochemical aspects of basal cell adenoma and canalicular
adenoma of salivary glands.
SO - Oral Oncol 2001 Jun;37(4):365-8
AD - Department of Oral Pathology, School of Dentistry, University of Sao
Paulo, Av. Prof. Lineu Prestes 2227, 05508-900, Sao Paulo, SP, Brazil.
scmsousa@fo.usp.br
Basal cell adenoma is a benign epithelial neoplasm with a uniform
histologic appearance dominated by basaloid cells. Those cells may be
distributed in various arrangements as solid, trabecular, tubular and
membranous. Canalicular adenoma is also a benign neoplasm composed by
columnar cells arranged in branching and interconnecting cords of single
or double cell thick rows. There is some disagreement among
investigators about whether canalicular adenoma should be included
within the basal cell adenoma histologic spectrum. In the present study
we compared the expression of cytokeratins (CK), vimentin and
muscle-specific actin, utilizing immunohistochemical technique, in three
cases diagnosed as basal cell adenomas predominantly of the solid type,
and three cases of canalicular adenomas. The results obtained showed a
distinct immunoprofile for both neoplasms. Solid areas of basal cell
adenomas did not stain for any of the tested antibodies; only when there
was tubular differentiation, those structures expressed CKs 7, 8, 14,
and 19 in luminal cells and vimentin in non-luminal cells. On the other
hand, canalicular adenomas strongly expressed CKs 7 and 13. The panel of
antibodies utilized supports the separation of the two entities.
13
UI - 11527159
AU - Esposito C; Zupi A; Califano L
TI -
Surgical therapy of parotid hemangiomas.
SO - Pediatr Surg Int 2001 Jul;17(5-6):335-7
AD - Department of Pediatric Surgery, School of Medicine and Surgery,
Federico II University of Naples, Italy.
The goal of this review is to define the clinical characteristics of
parotid hemangiomas in children and outline their therapeutic
management. The records of 42 pediatric patients with hemangiomas were
reviewed; 10 required surgical treatment. Two cases of temporary
postoperative facial nerve palsy were observed. Treatment was commonly
delayed, and there is a significant likelihood of spontaneous
regression. The indications for surgical intervention are an increase in
tumor size, rapid tumor growth, failure of tumor size to decrease and
hemorrhage into the lesion.
14
UI - 11555161
AU - Franchi A; Moroni M; Paglierani M; Santucci M
TI -
Expression of CD44 standard and variant isoforms in parotid gland and
parotid gland tumours.
SO - J Oral Pathol Med 2001 Oct;30(9):564-8
AD - Department of Human Pathology and Oncology, University of Florence
Medical School, Viale G.B. Morgagni 85, 50134 Florence, Italy.
In this study, we investigated the distribution of the standard form of
the CD44 (CD44s) cell adhesion molecule and of its v3 and v6 isoforms in
samples of foetal and adult parotid gland tissue, in comparison with
samples of parotid gland adenomas and carcinoma ex pleomorphic adenoma.
Foetal parotid gland showed CD44s and CD44v3 expression in the
peripheral small primordial ducts and acini, while CD44v6 was only
focally expressed. Adult parotid gland tissue showed a similar
distribution of CD44s and variants, with a predominant expression in
acinar structures and a weaker expression at duct level. In parotid
gland adenomas, a diffuse and intense expression of CD44s and variants 3
and 6 was observed only in pleomorphic adenomas, while expression of
CD44s was prevalent in Warthin's tumour, myoepithelioma and oncocytoma.
The malignant areas of carcinoma ex pleomorphic adenoma showed a
markedly decreased expression of CD44v3 and CD44v6 in comparison with
the adjacent pleomorphic adenoma component. In conclusion, the prevalent
expression of CD44s and variants in pleomorphic adenoma in comparison
with other adenomas may be related to the abundant extracellular matrix
production present in these tumours, while loss of CD44v3 and CD44v6
associated with the onset of carcinoma ex pleomorphic adenoma could
promote stromal invasion, eventually contributing to the development of
distant metastases.
15
UI - 11555785
AU - Jaehne M; Jakel KT; Roser K; Ussmuller J; Loning T
TI -
[About the prognostic value of Her-2 gene-amplification and
cell-proliferation in salivary duct carcinoma of the major salivary
glands - a pilot-study]
SO - Laryngorhinootologie 2001 Sep;80(9):525-9
AD - Klinik und Poliklinik fur Hals-Nasen-Ohrenheilkunde,
Universitatsklinikum Hamburg-Eppendorf, Germany.
jaehne@uke.uni-hamburg.de
INTRODUCTION: The salivary duct carcinoma (sdc) represents a rare
variant of the group of adeno-carcinomas of the salivary glands.
Histopathologically, it is marked by solid and cribriform cell nests
with central necrosis, displaying distinct similarity with the ductal
carcinoma of the breast, where prognosis can be correlated with Her-2
gene-amplification. Based on this histopathological similarity, the
prognostic value of Her-2 gene amplification in SDC was examined in the
presented pilot-study. PATIENTS AND METHODS: Four own patients with
different clinical courses were examined in regard to their
histopathological features, Her-2 gene-amplification and proliferation
(Ki67). RESULTS: Three of the four patients died tumor related 2.4, 5.5
and 8.2 years after initial diagnosis. The remaining patient died
tumor-free 6 year after diagnosis (myocardial infarct). The two patients
with an early recurrent disease and distant metastasis showed a high
Her-2 expression and proliferation (Ki67), compared to the other two
patients. CONCLUSION: In the presented pilot-study a distinct
correlation between Her2-gene-amplification, proliferation (Ki67) and
clinical course could be observed. Additional analysis to evaluate this
aspect seems rectified, especially under recognition of therapy
decisions.
16
UI - 11562768
AU - Hoang MP; Callender DL; Sola Gallego JJ; Huang Z; Sneige N; Luna MA;
TI -
Batsakis JG; El-Naggar AK
Molecular and biomarker analyses of salivary duct carcinomas: comparison
with mammary duct carcinoma.
SO - Int J Oncol 2001 Oct;19(4):865-71
AD - Department of Pathology, The University of Texas M.D. Anderson Cancer
Center, Houston, TX 77030, USA.
Salivary duct carcinoma (SDC) is a rare high-grade aggressive neoplasm
that manifests close histologic features with invasive ductal carcinoma
of the breast (IDC). In contrast to SDC, extensive molecular studies
have been performed on IDC and led to the identification of certain
biological markers. To investigate the underlying molecular and biologic
characteristics of SDC, we performed molecular analyses using
microsatellite markers on chromosomal arms 6q, 16q, 17p, and 17q, DNA
flow cytometry and immunohistochemical staining for androgen receptor
(AR) and p53 expression on 28 examples of these tumors in comparison to
24 IDC cases. Our results show that generally similar allelic
alterations, elevated p53 and androgen receptor expressions, and high
frequency of DNA aneuploidy are manifested in both SDCs and IDCs.
Differences at certain markers on 6q, 17p and 17q chromosomal loci,
however, were observed between the two entities. Certain loci on 6q were
more frequently altered in SDC than IDC which loci on chromosomes 17p
and q arms were more seen in IDCs than SDCs. The majority of SDCs had
high AR expression while most of IDCs were AR negative. Our study
indicates that: i) SDC may share some genetic alterations with IDC, ii)
high AR expression in SDC may play a role in tumor progression, and iii)
p53 overexpression and DNA aneuploidy in both entities reflect their
aggressive behavior.
17
UI - 11572247
AU - Carinci F; Farina A; Pelucchi S; Calearo C; Pastore A
TI -
Parotid gland carcinoma: surgical strategy based on local risk factors.
SO - J Craniofac Surg 2001 Sep;12(5):434-7
AD - Chair of Maxillofacial Surgery, University of Ferrara, Italy.
crc@unife.it
To evaluate the best surgical strategy in cases of parotid gland
carcinoma, local risk factors (T, N, histology, and treatment) were
analyzed in a series of 134 patients. The efficacy of the facial nerve
sacrifice in case of macroscopic tumor infiltration was tested by means
of survival analyses (Kaplan-Meier and Cox algorithms). This study
demonstrated that nerve preservation resulted in a better prognostic
value when compared with resection only in the group of patients having
a T1 or T2. In patients affected by T3 and T4, the different treatment
did not show any difference in survival rate. In conclusion, the
sacrifice of the facial nerve is not always able to improve the survival
rate.
18
UI - 11570911
AU - Khurana KK; Mortelliti AJ
TI -
The role of fine-needle aspiration biopsy in the diagnosis and
management of juvenile hemangioma of the parotid gland and cheek.
SO - Arch Pathol Lab Med 2001 Oct;125(10):1340-3
AD - Department of Pathology, SUNY Upstate Medical University Hospital,
Syracuse, NY 13210, USA. Khuranak@upstate.edu
BACKGROUND: The current recommendation for the management of juvenile
hemangiomas (JH) is to delay treatment in the hope of spontaneous
regression. However, accurate diagnosis is necessary before considering
conservative management. Traditionally, the diagnosis of JH has required
excisional biopsy. The cytology literature on this relatively rare
neoplasm is sparse. OBJECTIVE: To present our experience with
fine-needle aspiration in the diagnosis and management of JH. DESIGN:
Three cases with a cytologic diagnosis consistent with JH of the parotid
gland and cheek were identified from our cytopathology files. Aspirate
smears, immunohistochemical studies, computed tomographic scan findings,
and clinical follow-up were reviewed. RESULTS: Patients were female
infants ranging in age from 3 to 9 months and presented with an oval
firm mass (size range, 2.0-5.0 cm) involving the parotid gland (2 cases)
and cheek (1 case). Computed tomographic scan with contrast demonstrated
homogeneous enhancement. Aspirate smears revealed spindle-shaped cells
in sheets and clusters in a background of blood. The parotid gland
aspirates and cell block preparations revealed ductal structures
entrapped in sheets of spindle-shaped cells. Immunohistochemical studies
revealed prominent vascular spaces lined by CD34 and factor
VIII-positive flattened endothelial cells. The diagnosis of JH was
rendered on the basis of the cytologic findings in conjunction with the
radiologic and clinical findings. On clinical follow-up (8-24 months),
none of the patients has shown any progression of the lesion.
CONCLUSIONS: Fine-needle aspiration, in conjunction with imaging
studies, is a useful tool in the diagnosis and management of JH. It
eliminates the need for surgical excision for diagnostic purposes and
allows for clinical follow-up of patients with JH.
19
UI - 11590073
AU - Franca CM; Jaeger RG; Freitas VM; Araujo NS; Jaeger MM
TI -
Effect of N-CAM on in vitro invasion of human adenoid cystic carcinoma
cells.
SO - Oral Oncol 2001 Dec;37(8):638-42
AD - Universidade de Sao Paulo, Faculdade de Odontologia, Disciplina de
Patologia Bucal, Av. Prof. Lineu Prestes, 2227, 05508-900 Sao Paulo-SP,
Brazil.
Adenoid cystic carcinoma of salivary glands is characterised by
aggressive behaviour, high rate of local recurrences, neurotropism and
late metastasis. In a previous work we demonstrated that adenoid cystic
carcinoma cultured cells (CAC2 cells) expressed N-CAM. It was suggested
that this expression, modulated by extracellular matrix, would be
correlated to cell movement. The aim of our study was to verify whether
CAC2 cells presented invasion capacity. Moreover, we tested whether the
neural adhesion molecule (N-CAM) would participate in this process. CAC2
cells were either previously treated, or not (control), with a
monoclonal antibody against N-CAM. Invasion assays were carried out
using a modified Boyden chamber (Transwell chamber). CAC2 cells (10(5))
were dispensed into Transwell upper chamber on the top of Matrigel
coated filter. The cells that invaded the filters in the first 8 h were
counted under light microscopy, yielding data for the invasion rates
(%). Control CAC2 cells presented an invasion rate of 5.28+/-0.04%. The
invasion rate raised to 6.53+/-0.2% when N-CAM was blocked with
monoclonal antibody. N-CAM impaired the adenoid cystic carcinoma cell
invasion in vitro. Therefore, we suggest an anti-invasive role for N-CAM
in adenoid cystic carcinoma.
20
UI - 11593192
AU - Pirodda A; Ferri GG; Truzzi M; Cavicchi O
TI -
Benign cystic teratoma of the parotid gland.
SO - Otolaryngol Head Neck Surg 2001 Oct;125(4):429-30
AD - Department of Surgical and Anaesthesiological Sciences, ENT Section,
University of Bologna, S. Orsola Hospital, via Massarenti 9, 40138
Bologna, Italy.
21
UI - 11605225
AU - Shinohara S; Yamamoto E; Tanabe M; Maetani T; Fujiwara K; Kim T
TI -
[Evaluation of RI scintiscanning to parotid gland tumors]
SO - Nippon Jibiinkoka Gakkai Kaiho 2001 Sep;104(9):852-8
AD - Department of Otolaryngology, Kobe City General Hospital, Kobe.
We retrospectively evaluated preoperative radioisotope (RI) scintiscans
in 275 patients (283 glands) with parotid tumors who undergoing surgery
between 1987 and 2000. Technetium-99m-pertechnetate (Tc) scintigraphy
was conducted on 201 glands. Oncocytoma and Warthin's tumor showed a
high positive rate. In evaluating Warthin's tumor with Tc scintigraphy,
sensitivity was 75% and specificity 88%; above the age of 40 years,
specificity exceeded 90%. Gallium-67-citrate (Ga) scintigraphy was
conducted on 207 glands. Malignant parotid tumors showed high positivity
(85%), but the specificity of positive findings was quite low (38%)
because 44% of benign pleomorphic adenoma, which occupied major
material, showed Ga-positive findings. Ga-negative findings indicated
high probability (95%) of benign tumors. Thus, Tc scintigraphy is
effective in diagnosing Warthin's tumor, while Ga scintigraphy is
effective in diagnosing benign tumors.
22
UI - 11598171
AU - Okabe M; Inagaki H; Murase T; Inoue M; Nagai N; Eimoto T
TI -
Prognostic significance of p27 and Ki-67 expression in mucoepidermoid
carcinoma of the intraoral minor salivary gland.
SO - Mod Pathol 2001 Oct;14(10):1008-14
AD - Department of Pathology, Nagoya City University Medical School, Nagoya,
Japan.
p27 and Ki-67, a universal cyclin-dependent kinase inhibitor and a
proliferative cell marker, respectively, have been useful in predicting
clinical aggressiveness in various human tumors. We studied
clinicopathologic significance of these molecules in mucoepidermoid
carcinoma of the intraoral minor salivary gland. Expression of p27 and
Ki-67 was assessed immunohistochemically in primary mucoepidermoid
carcinomas from 31 patients without distant metastasis at surgery.
Correlation each of p27 and Ki-67 expression was analyzed with various
clinicopathologic parameters including age, sex, primary tumor site,
tumor size, nodal metastasis, clinical stage, and histologic grade. The
latter was evaluated using a point-scoring scheme of Auclair et al. that
consists of five histologic factors (intracystic component, neural
invasion, necrosis, mitosis, and anaplasia). p27 expression was
correlated inversely with histologic grade (P =.007), but with none of
other factors. When the correlation of p27 expression was further
examined with each of the histologic factors, it was correlated
significantly with intracystic component, but not with neural invasion,
necrosis, mitosis, or anaplasia. Ki-67 expression was correlated
significantly with histologic grade only in the clinicopathologic
factors (P <.0001), and in the histologic factors, with necrosis,
mitosis, and anaplasia. Multivariate prognostic analyses were performed
to identify independent risk factors for both disease-free and overall
survivals. Large tumor size (P =.031, relative risk = 5.5) and low p27
expression (P =.012, relative risk = 5.2) were risk factors for worse
disease-free survival. Low p27 expression (P =.015, relative risk =
15.2) was selected as a risk factor for worse overall survival. Other
factors including age, sex, tumor site, nodal status, clinical stage,
histologic grade, and Ki-67 did not emerge as independent risk factors
in either prognostic analysis. These data suggest that p27 may be useful
in estimating prognosis of the patients who have mucoepidermoid
carcinoma of the intraoral minor salivary gland.
23
UI - 11678950
AU - Teymoortash A; Lippert BM; Werner JA
TI -
Steroid hormone receptors in parotid gland cystadenolymphoma (Warthin's
tumour).
SO - Clin Otolaryngol 2001 Oct;26(5):411-6
AD - Department of Otolaryngology, Head and Neck Surgery, Philipps
University, Marburg, Germany. teymoort@mailer.uni-marburg.de
The aetiopathogenesis of cystadenolymphoma is mostly unknown.
Cystadenolymphomas have a significantly higher incidence in the male
than the female population. This might be as a result of endocrine
dependency in this kind of tumour. The purpose of the present study was
to determine the sex hormone receptor status in cystadenolymphoma.
Tissue samples of cystadenolymphoma, pleomorphic adenoma and normal
samples of the parotid gland were examined immunohistochemically for
oestrogen and progesterone receptors. Progesterone-positive cells could
be found in the salivary duct system of normal glands and in the
epithelial components of cystadenolymphomas. There was no evidence for
the presence of oestrogen receptor in any sample studied. The evidence
of progesterone receptors in cystadenolymphoma may implicate a potential
role of endocrine factors in the development of this tumour.
24
UI - 11683932
AU - Fornelli A; Eusebi V; Pasquinelli G; Quattrone P; Rosai J
TI -
Merkel cell carcinoma of the parotid gland associated with Warthin
tumour: report of two cases.
SO - Histopathology 2001 Oct;39(4):342-6
AD - Dipartimento di Oncologia, Sezione di Anatomia Istologia e Citologia
Patologica della Universita di Bologna, Bologna, Italy.
AIMS: Two cases of Merkel cell carcinoma occurring simultaneously and in
close association with a Warthin tumour of the parotid gland are
reported. METHODS AND RESULTS: The patients were a 65-year-old man and a
70-year-old man, respectively. The Merkel cell carcinoma component was
immunoreactive for chromogranin and keratin 20 and contained
neuroendocrine-type granules at the ultrastructural level. CONCLUSIONS:
The histogenesis of this heretofore undescribed combination is
discussed.
25
UI - 11683933
AU - Schwerer MJ; Kraft K; Baczako K; Maier H
TI -
Cytokeratin expression and epithelial differentiation in Warthin's
tumour and its metaplastic (infarcted) variant.
SO - Histopathology 2001 Oct;39(4):347-52
AD - Department of Pathology, Military Hospital Ulm, Ulm/Donau, Germany.
AIMS: Warthin's tumour is characterized by a bilayered columnar
epithelium. Transformation into metaplastic (infarcted) Warthin's tumour
includes squamous metaplasia of the epithelium along with regressive
changes in the stroma. Misinterpretation of metaplastic Warthin's tumour
for malignancy is a serious diagnostic pitfall. This study assesses the
utility of cytokeratin expression in Warthin's tumour and its
metaplastic variant. METHODS AND RESULTS: Twenty-six cases of Warthin's
tumour, among them eight metaplastic Warthin's tumours, were
investigated employing immunohistochemistry. Both Warthin's tumour and
its metaplastic variant regularly expressed cytokeratins (CK) 7, 8, 18,
and 19. Staining results with antibodies to CK10, 10/13, 1/2/10/11, and
20 were negative in all specimens. Immunoreactivity for CK 5/14 and 17
was restricted to basal cells in Warthin's tumour, but involved basal as
well as surface cells in metaplastic Warthin's tumour. CONCLUSIONS:
Warthin's tumour and its metaplastic (infarcted) variant both express CK
7, 8, 18, and 19, which are typical for columnar differentiation.
Cytokeratins typical of squamous differentiation are absent from
Warthin's tumour and its metaplastic variant, irrespective of the
squamous morphology of the epithelium in metaplastic Warthin's tumour.
The expression of CK 5/14 and 17, which are typical of regenerative
cells, is restricted to basal cells in Warthin's tumour, but is
expressed also in surface cells in metaplastic Warthin's tumour.
26
UI - 11692423
AU - Almela Cortes R; Faubel Serra M; Cueva Ruiz C; Conde Perez de la Blanca
TI -
I
[Intra-parotid facial plexiform neurofibroma. Review of the literature]
SO - An Otorrinolaringol Ibero Am 2001;28(4):363-70
AD - Servicio de ORL, Hospital General de Especialidades Ciudad de Jaen,
Jaen.
It is being tumor developed from Schwann cells of peripheral nerves
sheath. In its plexiform type it is a rare growth presenting solitary or
in the context of von Recklinghausen's disease. The aim of this article
is to present one plexiform neurofibroma localized in the parotid gland.
At the same time we make a perusal on the literature of this kind of
tumor.
27
UI - 11688044
AU - Siciliano S; Crevecoeur H; Weynand B; Reychler H
TI -
Primary neuroendocrine carcinoma of the parotid gland: a case report.
SO - J Oral Maxillofac Surg 2001 Nov;59(11):1359-62
AD - University Hospital St. Luc, Catholic University of Louvain, Brussels,
Belgium. Siciliano@stom.ucl.ac.be
28
UI - 11710645
AU - de Oliveira PT; Jaeger MM; Miyagi SP; Jaeger RG
TI -
The effect of a reconstituted basement membrane (matrigel) on a human
salivary gland myoepithelioma cell line.
SO - Virchows Arch 2001 Oct;439(4):571-8
AD - Department of Oral Pathology, School of Dentistry, University of Sao
Paulo, SP, Brazil.
We have already demonstrated that a reconstituted basement membrane
(Matrigel) is a key modulator of morphogenetic changes and
cytodifferentiation of pleomorphic adenoma cells in culture.
Myoepithelioma is considered to be a neoplasm closely related to
pleomorphic adenoma and should experience similar induction processes.
Thus, the aim of this study was to investigate whether Matrigel would
influence myoepithelioma cells. We used a cell line derived from a human
salivary gland plasmacytoid myoepithelioma (M1 cells) grown in a
three-dimensional preparation of Matrigel. Phenotype differences were
assessed using conventional light microscopy technique (haematoxylin and
eosin) and phase and differential interference contrast (Nomarski).
Immunofluorescence was carried out to detect smooth-muscle actin,
laminin and type-IV collagen. M1 cells exhibited all proteins studied,
showing a myoepithelial differentiation. M1 cells grown inside Matrigel
presented morphological changes and changes in smooth-muscle actin
status. By growing M1 cells inside Matrigel, it was possible to
reproduce the tumour architecture with no duct-like structures. Based on
our findings, we suggest that myoepithelioma would be derived from a
cell with a commitment to myoepithelial differentiation. We also suggest
that the mechanical properties of the matrix environment will likely
regulate smooth-muscle actin expression in myoepithelioma.
29
UI - 11710649
AU - Jaehne M; Jakel KT; Ussmuller J; Feller AC
TI -
Nasal NK/T-cell-lymphoma metastazising into the masseteric muscle
mimicking a parotid mass.
SO - Virchows Arch 2001 Oct;439(4):597-8
30
UI - 11704316
AU - Storey MR; Garden AS; Morrison WH; Eicher SA; Schechter NR; Ang KK
TI -
Postoperative radiotherapy for malignant tumors of the submandibular
gland.
SO - Int J Radiat Oncol Biol Phys 2001 Nov 15;51(4):952-8
AD - Department of Radiation Oncology, The University of Texas, M.D. Anderson
Cancer Center, Houston, TX, USA.
PURPOSE: This retrospective study assessed the outcome and patterns of
failure for patients with malignant submandibular tumors treated with
surgery and postoperative radiation. METHODS AND MATERIALS: Between 1965
and 1995, 83 patients aged 11-83 years old received postoperative
radiotherapy after resection of submandibular gland carcinomas. The most
common radiation technique was an appositional field to the
submandibular gland bed using electrons either alone or mixed with
photons. Primary tumor bed doses ranged from 50 to 69 Gy (median, 60
Gy). Regional lymph nodes (ipsilateral Levels I-IV) were irradiated in
66 patients to a median dose of 50 Gy. Follow-up time ranged from 5 to
321 months (median, 82 months). RESULTS: Actuarial locoregional control
rates were 90%, 88%, and 88% at 2, 5, and 10 years, respectively. The
corresponding disease-free survival rates were 76%, 60%, and 53%,
because 27 of 74 patients (36%) who attained locoregional control
developed distant metastases. Adenocarcinoma, high-grade histology, and
treatment during the earlier years of the study were associated with
worse locoregional control and disease-free survival. The median
survival times for patients with and without locoregional control were
183 months and 19 months, respectively. Actuarial 2-, 5-, and 10-year
survival rates were 84%, 71%, and 55%, respectively. Late complications
occurred in 8 patients (osteoradionecrosis, 5 patients). CONCLUSIONS:
High-risk cancers of the submandibular gland have a historic control
rate of approximately 50% when treated with surgery alone. In the
current series, locoregional control rates for high-risk patients with
submandibular gland cancers treated with surgery and postoperative
radiotherapy were excellent, with an actuarial locoregional control rate
of 88% at 10 years.
31
UI - 11715527
AU - Wang J; Dong F; Yong P
TI -
[Tumour suppressor p53 gene sequence mutations in pleomorphic adenoma of
salivary gland]
SO - Zhonghua Yi Xue Za Zhi 1999 Oct;79(10):777-9
AD - School of Stomatology, Hebei Medical University, Shijiazhuang 050017.
OBJECTIVE: To detect p53 exon 7 and 8 mutation and to study genesis and
biological characteristics of pleomorphic adenoma of salivary galand.
METHODS: Polymerase chain reaction- single-strand conformational
polymorphism (PCR-SSCP) and DNA sequencing analysis were used. RESULTS:
PCR-SSCP analysis showed that in 11 patients with positive SSCP, 7
showed abnormal exon 7 and 3 abnormal exon 8. Comparison of SSCP results
with DNA sequencing showed that patients all patients with p53 exon 7
and 8 mutations were SSCP positive. Exon 7 mutation pattern was point
mutation(T-->C). Exon 8 mutation pattern included base substitution
(point mutation) (C-->A) and frame-shiftmutation (base insertion and
base loss). CONCLUSIONS: Polycodon and poly-pattern mutations appeared
in p53 exon 7 and 8. Pleomorphic adenoma of salivary galand was similar
to malignant tumor in p53 gene mutation. Poly-codon mutation could occur
in the same case.
32
UI - 11718383
AU - Browne RF; Golding SJ; Watt-Smith SR
TI -
The role of MRI in facial swelling due to presumed salivary gland
disease.
SO - Br J Radiol 2001 Feb;74(878):127-33
AD - Department of Radiology, University of Oxford, John Radcliffe Hospital,
Headington, UK.
50 consecutive patients presenting with facial swelling thought
clinically to be due to salivary gland disease underwent MRI.
Examinations were interpreted by one radiologist without access to
previous investigations. Records were reviewed to determine the
reliability and role of MRI in patient management, and the contribution
of other prior or subsequent investigations. MRI findings were verified
against operative findings, percutaneous biopsy or clinical follow-up
(periods ranging from 8-58 months). A mass was found in 27 patients; in
11 of these patients, disease was extrinsic to the salivary gland. MRI
diagnosis of tumour was correct in all patients and MRI was a reliable
investigation for planning surgical resection. No mass was found in 23
patients, 8 of whom had normal appearan
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