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NCI CANCERLIT^® Search: Adrenocortical Carcinoma - May 2002

Imprima English

National Cancer Institute^®
Ultima Vez Modificado: 1 de mayo del 2002

Isoforms of protein kinase C and their distribution in human adrenal cortex and tumors.

Adrenocortical tumor in an adult detected by Ga-67 scintigraphy.

Functioning adrenocortical neoplasms in children.

Table of Contents

1
UI - 11740573
AU - Mikosha AS; Tron'ko ND; Staren'kii DV; Rybakov SI
TI - Isoforms of protein kinase C and their distribution in human adrenal cortex and tumors.
SO - Bull Exp Biol Med 2001 Sep;132(3):841-3
AD - V. P. Komissarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kiev. endo@i.kiev.ua
The cytosol and microsomal fractions of human adrenal cortex contain 3 isoforms of protein kinase C: alpha, zeta, and epsilon. The latter fraction is present in trace amounts. No isoforms beta1, beta2, gamma and delta were found in these cell fractions. The distribution of alpha-isoform between the cytosol and microsomal fraction is determined by tissue origin: in normal tissue its content differs by no more than 10%, while in most tumors this isoform is translocated into the microsomal fraction. The distribution of zeta-isoform did not depend on tissue origin.

2
UI - 11805492
AU - Hershcovici T; Feinmesser M; Steinmetz AP; Hardoff R
TI - Adrenocortical tumor in an adult detected by Ga-67 scintigraphy.
SO - Clin Nucl Med 2002 Jan;27(1):60-1
AD - Department of Internal Medicine A, Rabin Medical Center, Petah Tiqva, Israel.

3
UI - 11942965
AU - Patil KK; Ransley PG; McCullagh M; Malone M; Spitz L
TI - Functioning adrenocortical neoplasms in children.
SO - BJU Int 2002 Apr;89(6):562-5
AD - Great Ormond Street Hospital, University Hospital Lewisham, UK. kalpanakp@aol.com
OBJECTIVE: To describe the clinical features, treatment and outcome of functioning adrenocortical tumours in children, and to assess the value of tumour size as a marker for malignant potential. PATIENTS AND METHODS: Twenty-one children (mean age at presentation 4.9 years, range 0.6-11; 12 girls and nine boys) who presented with a functioning adrenal mass over a 29-year period (1972-2000) were assessed. Clinicopathological features and outcome information were obtained from a structured review of the case-notes. Before 1980 the diagnosis and staging was mainly obtained by intravenous pyelography and plain X-ray. Since 1980, ultrasonography, computed tomography and more recently magnetic resonance imaging were the methods of choice. RESULTS: The mean (range) duration of symptoms before diagnosis was 31 (2-108) months. The symptoms and signs at presentation comprised virilization (18 children), Cushingoid features (three), precocious puberty (three) and hypertension (four). Three children had malignant neoplasms, one presented with metastasis and of the other two, one died from the disease within 6 months, despite adjuvant chemotherapy and radiotherapy. The third girl is disease-free 11 years after complete excision of the neoplasm. Eighteen children had a benign neoplasm and all are alive and free of recurrence. In most of the children surgical extirpation was relatively simple, blood loss minimal, recovery uneventful and the hospital stay short (mean 5 days). The virilizing effects of all the neoplasms gradually resolved after surgery within a median (range) of 27 (6-108) months. CONCLUSIONS: Functioning adrenocortical neoplasms in children are rare, with a peak incidence in the first decade, are predominantly unilateral and more common in girls. Most are benign, but both benign and malignant lesions can present with virilizing and Cushingoid features. The malignant neoplasms have an extremely poor prognosis, especially if excision is incomplete, despite adjuvant chemotherapy and radiotherapy. Although there is an association between tumour size and malignancy, this cannot be used as a reliable individual discriminator.

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