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NCI CANCERLIT^® Search: Penile Cancer - April 2002

Imprima English

National Cancer Institute^®
Ultima Vez Modificado: 1 de abril del 2002

Secondary tumours of the penis.

Large granular cell tumor of the penis in a 53-year-old man with coexisting prostate cancer.

Small bowel obstruction as a unique complication of squamous cell carcinoma of the penis.

[Carcinoma in situ of the penis rapidly progressing after carbon dioxide laser treatment]

Squamous cell carcinoma in situ of the penis successfully treated with imiquimod 5% cream.

Table of Contents

1
UI - 11872774
AU - Bates AW; Baithun SI
TI - Secondary tumours of the penis.
SO - J R Soc Med 2002 Mar;95(3):162-3

2
UI - 11927333
AU - Carver BS; Venable DD; Eastham JA
TI - Large granular cell tumor of the penis in a 53-year-old man with coexisting prostate cancer.
SO - Urology 2002 Apr;59(4):602
AD - Department of Urology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA.
Granular cell tumors are soft tissue neoplasms that rarely involve the male external genitalia. Thus far, only 7 cases of granular cell tumor of the penis have been reported. We report a case of granular cell tumor of the penis in a man undergoing radical retropubic prostatectomy for organ-confined adenocarcinoma of the prostate.

3
UI - 11873122
AU - Sapozhnikov E; Zakko S; Remoroza R; Aziz K; Levine J; Shah M; Henisz AK;
TI - Giebisch NX Small bowel obstruction as a unique complication of squamous cell carcinoma of the penis.
SO - J Clin Gastroenterol 2002 Mar;34(3):289-90

4
UI - 11968805
AU - Tsukamoto T; Yonese J; Kin T; Samejima T; Hasegawa Y; Fukui I; Ishikawa
TI - Y [Carcinoma in situ of the penis rapidly progressing after carbon dioxide laser treatment]
SO - Nippon Hinyokika Gakkai Zasshi 2002 Mar;93(3):483-6
AD - Department of Urology, Cancer Institute Hospital.
Laser treatment is considered to be effective in treating carcinoma in situ of the penis. We, however, report a case with carcinoma in situ of the penis which developed invasive carcinoma and inguinal lymphnode metastases only 6 months after the laser treatment. A 74-year-old man with pseudophimosis presented with redness of the glans penis. A physical examination revealed thick erythema, 12 millimeters in diameter, around the external urethral meatus. Histologically, biopsy revealed squamous cell carcinoma in situ. No metastasis was suspected by physical examination and imaging studies. Although the lesion appeared to slightly extend into the urethra, it was primarily treated with the CO2 laser. Six months after the treatment, however, local recurrence was confirmed by the touch smear cytology, resulting in the partial amputation of the penis. The histopathological examination revealed subepithelial and marked lymphatic invasion of the tumor and positive margin in the urethral stump (squamous cell carcinoma in situ). Further, since bilateral superficial inguinal lymphnode swelling appeared, total amputation of the penis with perineal urethrotomy and pelvic/inguinal lymphnode dissection was performed subsequently. The metastases to bilateral inguinal lymphnodes were confirmed histologically. The patient received adjuvant chemotherapy and has been alive and well without evidence of disease 40 months after the initial treatment.

5
UI - 11907505
AU - Schroeder TL; Sengelmann RD
TI - Squamous cell carcinoma in situ of the penis successfully treated with imiquimod 5% cream.
SO - J Am Acad Dermatol 2002 Apr;46(4):545-8
AD - Washington University, St. Louis, MO 63141, USA.
BACKGROUND: Multiple treatments for squamous cell carcinoma in situ (SCCIS) of the penis have been used with variable success and morbidity. Surgery and destructive treatment modalities have significant risk of scarring, deformity, and impaired function. OBJECTIVE: The purpose of this study was to determine whether topical imiquimod 5% cream is a potentially effective treatment for SCCIS of the penis and to qualify treatment associated morbidity. METHODS: The case of a patient with extensive penile SCCIS is reported. The patient was treated with topical imiquimod 5%, administered daily until blistering occurred (2 cycles). Biopsy specimens were obtained to confirm tumor clearance. RESULTS: One month after therapy was completed, no clinical or histologic evidence of residual tumor was found. Adverse effects of imiquimod included localized tenderness and erythema. No evidence of scarring, deformity, loss of function, or tumor recurrence was noted 18 months after treatment. CONCLUSION: Imiquimod 5% cream may represent an alternative treatment option for SCCIS of the penis.

The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.

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