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NCI CANCERLIT^® Search: Gastrointestinal Carcinoid Tumor - April 2002

Imprima English

National Cancer Institute^®
Ultima Vez Modificado: 1 de abril del 2002

[von Recklinghausen disease associated with intrahepatic cholangiocarcinoma and ampullary carcinoid]

Gastric carcinoid tumors without autoimmune gastritis in Japan: a relationship with Helicobacter pylori infection.

[A case of gastric carcinoids associated with type A gastritis and gastric cancer]

Levels of angiogenic peptides in sera from patients with carcinoid tumours during alpha-interferon treatment.

Recurrent hemorrhage caused by ileal carcinoid.

[A case of multiple gastric carcinoid tumor with type A gastritis treated by distal gastrectomy]

Table of Contents

1
UI - 11808180
AU - Takeuchi Y; Nagata K; Yokota T; Handa M; Matsunaga H; Nishio Y; Kusugami
TI - K [von Recklinghausen disease associated with intrahepatic cholangiocarcinoma and ampullary carcinoid]
SO - Nippon Naika Gakkai Zasshi 2001 Dec 10;90(12):2467-9
AD - Department of Internal Medicine, Shizuoka Kousei Hospital, Shizuoka.

2
UI - 11911346
AU - Sato Y; Iwafuchi M; Ueki J; Yoshimura A; Mochizuki T; Motoyama H;
TI - Sugimura K; Honma T; Narisawa R; Ichida T; Asakura H; Van T Gastric carcinoid tumors without autoimmune gastritis in Japan: a relationship with Helicobacter pylori infection.
SO - Dig Dis Sci 2002 Mar;47(3):579-85
AD - Third Department of Internal Medicine, Faculty of Health Science, Niigata University School of Medicine, Japan.
In Japan, most cases of gastric carcinoid tumor (GCT) are unassociated with either autoimmune gastritis (AIG) showing type-A chronic atrophic gastritis (CAG-A) or Zollinger-Ellison syndrome (ZES). However, the pathogenesis of this tumor remains unknown. Recent studies have determined that Helicobacter pylori infection induces gastric carcinoid in Mongolian gerbils and that H. pylori lipopolysaccharide exerts a mitogenic effect on ECL cells. We examined five patients with histologically diagnosed GCT, 40 patients with H. pylori-positive gastric ulcer (Hp+GU), 24 patients with H. pylori-positive duodenal ulcer (Hp+DU), and 12 patients with AIG showing CAG-A topographically. We compared the prevalence of H. pylori infection, and the levels of gastrin and pepsinogen (PG) in the serum of patients with GCT with those of patients with Hp+GU, or Hp+DU, and AIG. We also investigated the histological characteristics of the tumor and the gastric corpus mucosa in the GCT patients. The levels of serum gastrin and PG I and II were measured using an RIA kit. In all five (100%) patients with GCT, H. pylori infection was present, without any evidence of AIG or ZES. The serum levels of gastrin in the GCT patients were higher than those in either Hp+GU or Hp+DU patients and lower than those in the AIG patients. In contrast, serum PG I levels and the PG I/II ratio were lower in the GCT group than in the Hp+GU or Hp+DU groups. Histologically, all GCTs were ECL cell tumors and peritumoral corporal mucosal atrophy was observed in four of the five patients with GCT. In conclusions, H. pylori infection and hypergastrinemia were found in the patients with GCT without AIG. This finding suggests that H. pylori infection may induce corporal mucosal atrophy and hypergastrinemia that can produce a GCT with time.

3
UI - 11925864
AU - Hiroyoshi M; Ogino K; Moritomo H; Kitagawa T; Yamamoto H; Watahiki H;
TI - Ogawa H; Nagata Y [A case of gastric carcinoids associated with type A gastritis and gastric cancer]
SO - Nippon Shokakibyo Gakkai Zasshi 2002 Mar;99(3):270-4
AD - Department of Surgery, Seirei Mikatahara Hospital.

4
UI - 11911297
AU - Nilsson A; Janson E T; Eriksson B; Larsson A
TI - Levels of angiogenic peptides in sera from patients with carcinoid tumours during alpha-interferon treatment.
SO - Anticancer Res 2001 Nov-Dec;21(6A):4087-90
AD - Department of Medical Sciences, University Hospital, Uppsala, Sweden.
BACKGROUND: Alpha-interferon, a known inhibitor of angiogenesis and cell proliferation, is used in the standard treatment of patients with carcinoid tumors. We studied the levels of two angiogenic peptides (bFGF and VEGF) in sera from patients with carcinoid tumours before and during treatment with alpha-interferon. The aim was to investigate if the antitumoral effect of alpha-interferon in these patients could be at least in part explained by a reduction in the measured angiogenetic peptides. PATIENTS AND METHODS: Sera from 29 patients with carcinoid tumours were collected before and during alpha-interferon treatment and analyzed using commercially available ELISA-kits. RESULTS: Interferon alpha treatment did not cause reduction of bFGF and VEGF levels in serum from patients with carcinoid tumours. In fact there was no correlation between changes in bFGF or VEGF levels and treatment effect. CONCLUSION: The action of alpha-interferon does not seem to be mediated by bFGF or VEGF in patients with carcinoid tumours. If alpha-interferon has an anti-angiogenic effect in this patient group, it is probably mediated by angiogenic peptides other than bFGF and VEGF.

5
UI - 11923773
AU - Tang SJ; Jutabha R
TI - Recurrent hemorrhage caused by ileal carcinoid.
SO - Gastrointest Endosc 2002 Apr;55(4):559
AD - UCLA Center for the Health Sciences, Los Angeles, California, USA.

6
UI - 11979736
AU - Tohdo H; Akagi M; Chikamatsu S; Miura T; Watanabe T; Haruma K; Shimamoto
TI - F; Yoshida K; Toge T [A case of multiple gastric carcinoid tumor with type A gastritis treated by distal gastrectomy]
SO - Nippon Shokakibyo Gakkai Zasshi 2002 Apr;99(4):386-90
AD - Department of Internal Medicine, Hiroshima Prefectual Akitsu Hospital.

The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.

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