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NCI CANCERLIT^® Search: Gestational Trophoblastic Neoplasms - October 2001

Imprima English

National Cancer Institute^®
Ultima Vez Modificado: 21 de noviembre del 2001

Different transporters for tri-iodothyronine (T(3)) and thyroxine (T(4)) in the human choriocarcinoma cell line, JAR.

Choriocarcinoma and human immunodeficiency virus (HIV) infection: a case report.

Images in radiology: complete hydatidiform mole with live pregnancy in a twin gestation.

Serum human chorionic gonadotropin regression pattern in persistent trophoblastic disease during chemotherapy.

[Typical forms of choriocarcinoma in clinical practice--diagnosis and therapeutic course in four patients]

[Regression of hCG in various types of molar pregnancies--clinical course and prognosis]

The diagnosis of hydatidiform mole in early tubal ectopic pregnancy.

Pregnancy outcomes of patients who conceived within 1 year after chemotherapy for gestational trophoblastic tumor: a clinical report of

Possible influence of granulocyte colony-stimulating factor and recombinant human erythropoietin on human chorionic gonadotropin

Hydatidiform moles and teratomas confirm the human identity of the preimplantation embryo.

Intracranial haemorrhage resulting from unsuspected choriocarcinoma metastasis.

Table of Contents

1
UI - 20567693
AU - Powell KA; Mitchell AM; Manley SW; Mortimer RH; Mortimer RH
TI - Different transporters for tri-iodothyronine (T(3)) and thyroxine (T(4)) in the human choriocarcinoma cell line, JAR.
SO - J Endocrinol 2000 Dec;167(3):487-92
AD - Conjoint Endocrine Laboratory, Royal Brisbane Hospital Research Foundation, The Bancroft Centre, 300 Herston Road, Brisbane, Queensland 4029, Australia. kellieP@qimr.edu.au
We investigated transport systems for tri-iodothyronine (T(3)) and thyroxine (T(4)) in the human choriocarcinoma cell line, JAR, using a range of structurally similar compounds to determine whether these thyroid hormones are transported by common or different mechanisms. Saturable T(3) but not saturable T(4) uptake was inhibited by a wide range of aromatic compounds (nitrendipine, nifedipine, verapamil, meclofenamic acid, mefenamic acid, diazepam, phenytoin). Nitrendipine and diazepam were the most effective inhibitors of saturable thyroid hormone uptake. Nitrendipine decreased the K(m) for T(4) uptake from a control value of around 500 nM to around 300 nM (n=6). In contrast, the K(m) for T(3) uptake was increased from a control value of around 300 nM to around 750 nM (n=4). Diazepam had similar effects. This divergent shift in affinity for the uptake of T(3) and T(4) suggested that separate uptake systems exist for these two thyroid hormones. This provides evidence for at least two transporters mediating uptake of T(3) and T(4) in JAR cells: a specific T(4) transporter that does not interact with T(3) or structurally similar compounds; and a shared iodothyronine transporter that interacts with T(3), T(4), nitrendipine and diazepam.

2
UI - 21411924
AU - Moodley M; Moodley J
TI - Choriocarcinoma and human immunodeficiency virus (HIV) infection: a case report.
SO - Int J Gynecol Cancer 2001 Jul-Aug;11(4):329-30
AD - MRC/UN Pregnancy Hypertension Research Unit and Department of Obstetrics and Gynaecology, University of Natal Medical School, Durban, South Africa.
The appropriate management of gynecological malignancies in human immunodeficiency virus (HIV)-infected patients is uncertain. Gestational trophoblastic disease is highly curable and occurs predominantly among young females. However, such patients are often immunocompromised and cytotoxic agents may further compromise immunity. This case report demonstrates the successful management of choriocarcinoma in a HIV-infected patient.

3
UI - 21329270
AU - Narlawar RS; Shah J; Patkar D
TI - Images in radiology: complete hydatidiform mole with live pregnancy in a twin gestation.
SO - J Postgrad Med 2000 Oct-Dec;46(4):291-2
AD - Department Of Radiology, K.E.M. Hospital, Parel, Mumbai, India. drranjeet@hotmail.com

4
UI - 21420047
AU - Lertkhachonsuk R; Limpongsanurak S
TI - Serum human chorionic gonadotropin regression pattern in persistent trophoblastic disease during chemotherapy.
SO - J Med Assoc Thai 2001 Jun;84 Suppl 1():S352-9
AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
The objective of this study was to identify the regression pattern of serum beta-hCG in persistent trophoblastic disease patients after initiating chemotherapy. Eighty-nine women who were diagnosed as persistent trophoblastic disease in King Chulalongkorn Memorial Hospital chemotherapy were included. The incidence was 20.2 per cent of total gestational trophoblastic disease patients. Seventy-two (80.9%) from 89 patients were recruited in our study. Sixty-four (88.9%) patients responded to first-line chemotherapy and 8 patients (11.1%) resisted. Suction curettage was done as initial treatment in 61 (84.7%) cases. Most of them (95.8%) received actinomycin-D as first line treatment. Total courses of chemotherapy averaged 4 courses, but increased to 8.5 courses in the resistant group. Mean time of serum beta-hCG to remission was 16.7 and 21.5 weeks in the chemo-sensitive and chemo-resistant group, respectively. Average time to start chemotherapy was in the tenth week, and in the resistant group it was started in the sixth week. Chemotherapy regimen was changed in the fifteenth week. Initial serum beta-hCG levels were not significantly different between the two groups. The reduction rates of beta-hCG were significantly different from the third to the seventh week in the chemo-sensitive and chemo-resistant groups, which was during the second and third course of chemotherapy (P<0.05). In conclusion, by using the reduction rate, the regression pattern of serum beta-hCG level in persistent trophoblastic disease patients was significantly different between the chemosensitive and chemoresistant group from the third to the seventh week after starting chemotherapy.

5
UI - 21426104
AU - Gurlit L; Lampe S; Goeschen K; Krech R; Hartlapp HJ; Bohmer S
TI - [Typical forms of choriocarcinoma in clinical practice--diagnosis and therapeutic course in four patients]
SO - Zentralbl Gynakol 2001 Jul;123(7):383-9
AD - Frauenklinik, Klinikum Osnabruck.
The paper reports on four patients with choriocarcinoma. In two of them, the choriocarcinoma was found after abortion, in one of them following termination of pregnancy, and in the last patient a hydatidiform mole was present. In all patients increased beta-HCG was found. One patient had lung metastasis at the time of diagnosis. In another patient, choriocarcinoma was suspected owing to ultrasonographic vaginal examination. According to the Bagshawe Score, 3 patients were low-risk and were subjected to methotrexate. One patient was medium-risk and received PEB chemotherapy. All four patients are regarded as cured.

6
UI - 21452205
AU - Rob L; Robova H; Pluta M; Kulovany E; Hrehorcak M; Chmel R; Schlegerova
TI - D; Kodet R; Macek M [Regression of hCG in various types of molar pregnancies--clinical course and prognosis]
SO - Ceska Gynekol 2001 Jul;66(4):230-5
AD - Gynekologicko-porodnicka klinika, onkogynekologicke oddeleni, 2. LF UK Praha.
OBJECTIVE: To evaluate spontaneous regression curves of hCG serum positivity in patients with surgically treated molar pregnancies. Comparison of complete, partial and invasive mole. The study should result in optimalisation of follow up criteria of molar pregnancies in respect to their potential malignant change. DESIGN: Retrospective comparative clinical study. SETTING: Obst. Gyn. Dpt., Oncogynecology div., 2nd Medical Faculty, FNM, Charles University Prague, Pathology Dpt., 2nd Medical Faculty, Institute of Biology and Medical Genetics. METHODS: Evaluation of spontaneous regression curves of serum hCG levels in 104 molar pregnancies. 46 patients with partial hydatiform mole, 48 patients with complete hydatiform mole, 10 patients with invasive mole. Serum hCG levels were detected by radioimunoassay (RIA) in the first period and imunochemoluminisent assay (LIA) in the second period. Regression curves of hCG positivity in particular moles were statistically evaluated by Fischer test and t-test. RESULTS: There is statistically significant difference in spontaneous regression of hCG positivity in different types of molar pregnancies. Recommended criteria for gestational trofoblastic disease (GTD) diagnosis and follow up are fully applicable in clinical practice. There is exception in partial hydatiform moles, where plateau in hCG regression does not necessarily implicate chemotherapy in patient with good compliance. CONCLUSION: Early diagnosis of GTD predominantly due to the widespread use of ultrasonography changes classical clinical features of molar pregnancies. Spontaneous regression in hCG positivity in serum is more rapid in patients with partial hydatiform mole, slower in complete hydatiform mole and invasive mole. There is no significant change in malignant potential regarding early detection and treatment.

7
UI - 21423772
AU - Rees HC; Paradinas FJ
TI - The diagnosis of hydatidiform mole in early tubal ectopic pregnancy.
SO - Histopathology 2001 Sep;39(3):320-1
AD - Charing Cross Department of Histopathology, The Hammersmith Hospitals NHS Trust, London, UK.

8
UI - 21469903
AU - Lan Z; Hongzhao S; Xiuyu Y; Yang X
TI - Pregnancy outcomes of patients who conceived within 1 year after chemotherapy for gestational trophoblastic tumor: a clinical report of 22 patients.
SO - Gynecol Oncol 2001 Oct;83(1):146-8
AD - Department of Ob/Gyn, Peking Union Medical College Hospital, Beijing 100730, China.
OBJECTIVE: The aim of this study was to explore the risk of pregnancy of patients who conceived within 1 year after successful chemotherapy for gestational trophoblastic tumor (GTT). METHODS: From 1966 to 1996, 22 patients who conceived within 1 year after chemotherapy were followed up and analyzed retrospectively. RESULTS: Among 22 patients, 9 had term deliveries and 1 had a premature birth, 6 had induced abortion at the patient's request, and 6 had therapeutic abortion because of various indications such as repeated hydatidiform mole (1 case), intrauterine death (1 case), inevitable abortion (1 case), and threatened abortion (3 cases). The fetal loss rate was 27.1% (6/22). The incidence rate of gestational trophoblastic disease (GTD) was 9.1% (2/22). The incidence rate of GTT was 4.5% (1/22). The average interval between completion of chemotherapy and pregnancy was 10.25 months in the group of term pregnancies and 5.86 months in that of fetal loss (P < 0.05), indicating that the longer the interval, the lesser the risk of GTD. CONCLUSION: The results suggest that contraception for 1 year is necessary in patients with GTT after successful chemotherapy. However, in the case of a patient who conceives within 1 year, it is not necessary to terminate pregnancy, but the pregnancy must be carefully watched. Copyright 2001 Academic Press.

9
UI - 21469907
AU - Losch A; Lahodny J; Petru E
TI - Possible influence of granulocyte colony-stimulating factor and recombinant human erythropoietin on human chorionic gonadotropin secretion during chemotherapy for choriocarcinoma.
SO - Gynecol Oncol 2001 Oct;83(1):165-6

10
UI - 91147859
AU - Suarez A
TI - Hydatidiform moles and teratomas confirm the human identity of the preimplantation embryo.
SO - J Med Philos 1990 Dec;15(6):627-35
AD - Interdisciplinary Study Center, Zurich, Switzerland.
Results of recent research on hydatidiform moles and teratomas show that during pregnancy the embryo does not receive any message or information from the mother able to control the mechanisms of development or to produce the type of cellular differentiation necessary for building the tissues of the new human adult. Thus, the biological identity of the new human being does not depend on the sojourn in the uterus; the preimplantation embryo is the same individual of the human species as the adult, into whom the embryo can in principle develop.

11
UI - 21477248
AU - Suresh TN; Santosh V; Shastry Kolluri VR; Jayakumar PN; Yasha TC;
TI - Mahadevan A; Shankar SK Intracranial haemorrhage resulting from unsuspected choriocarcinoma metastasis.
SO - Neurol India 2001 Sep;49(3):231-6
AD - Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India.
A retrospective analysis of clinicopathological data of 10 patients with clinically unsuspected cerebral metastatic choriocarcinoma was carried out. All patients were young adult females. History of preceding pregnancy/abortion was forthcoming in 5 cases but none had a prior history of abnormal gestation. Features of raised intracranial tension followed by hemiparesis were the commonest presenting symptoms. A clinicoradiologic diagnosis of intracerebral haemorrhagic mass, either primary or secondary to tumour bleed, cortico-venous thrombosis or arteriovenous malformation, was entertained in 8 out of 10 cases. In other two cases, ring enhancing lesions prompted the diagnosis of granulomatous masses. Eight patients were operated upon, of whom two died after short hospital stay, and were autopsied. All had haemorrhagic masses noted at surgery/autopsy. Accurate diagnosis of metastatic choriocarcinoma was established only by histologic examination of these haemorrhages. This report emphasizes the importance of considering metastatic choriocarcinoma as an important differential diagnosis of haemorrhagic intracerebral lesions in women of child bearing age group. Measurement of serum/CSF level of HCG in suspected cases helps to implement early therapy. The diagnostic value of histopathologic examination of surgically resected blood clots in determining aetiology of intracerebral haemorrhagic masses is highlighted.

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