NCI CANCERLIT^® Search: AIDS-Related Lymphoma - September 2001

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Ultima Vez Modificado: 1 de noviembre del 2001

[Primary pericardial lymphoma in HIV infection]
[Opportunistic episodes in patients infected with the human immunodeficiency virus during the first 6 months of HAART]
Epidemiological, biological and clinical features of HIV-related lymphomas in the era of highly active antiretroviral therapy.
[A 33-year-old male infected by the human immunodeficiency virus with vomiting and abdominal pain of 15 days of duration]
Detection of abundantly transcribed genes and gene translocation in human immunodeficiency virus-associated non-Hodgkin's lymphoma.

CancerMail from the National Cancer Institute

1
UI - 21388605
AU - Lizarralde Palacios E; Baraia-Etxaburu Artetxe J; Zubero Sulibarria Z; Teira Cobo R; Munoz Sanchez J; Santamaria Jauregui JM
TI - [Primary pericardial lymphoma in HIV infection]
SO - An Med Interna 2001 Apr;18(4):220

2
UI - 21352930
AU - Gonzalez-Castillo J; Blanco F; Soriano V; Barreiro P; Concepcion Bravo M; Jimenez-Nacher I; Gonzalez-Lahoz J
TI - [Opportunistic episodes in patients infected with the human immunodeficiency virus during the first 6 months of HAART]
SO - Med Clin (Barc) 2001 Jun 23;117(3):81-4
AD - Servicio de Enfermedades Infecciosas, Hospital Carlos III, Instituto de Salud Carlos III, Madrid. jgdelcastillo@terra.es
BACKGROUND: We aimed at analysing the incidence and characteristics of opportunistic events (OE) within a few months after starting highly active antiretroviral therapy (HAART) in HIV infected patients. PATIENTS AND METHOD: Retrospective study of HIV infected outclinic patients attended in a HIV/AIDS reference hospital in Madrid, who initiated HAART during the second semester of 1998, with a baseline CD4 cell count 250 x 10(6) cells/l. We recorded the incidence of OE within 6 months after beginning HAART and analysed virological and immunological parameters, sociodemographic variables and types of antiretroviral treatment. RESULTS: The study included 269 patients. Twenty-one (7.8%) OE were recorded. At the onset of HAART, the mean CD4 cell count in these 21 patients was 137 (92) x 10(6)/land the median viral load was 24,043 cop/ml. At the time of OE diagnosis, these parameters were 218 (114) x 10(6)/l (p = 0.012) and < 500 cop/ml, respectively. OE were distributed as follows: herpes zoster, 9 cases (43%), Pneumocystis carinii pneumonia, 5 cases (24%), Kaposi sarcoma,3 cases (14%) and tuberculosis, cerebral toxoplasmosis, cytomegalovirus retinitis, and non-Hodgkin lymphoma, 1 case each. Overall, 78% of OE occurred within first 4 months after beginning HAART. In addition, an OE was developed by 8% patients treated with NRTI and PI, 2% treated with NRTI and NNRTI, and 10% treated with NRTI,NNRTI and PI (p = 0.44). CONCLUSIONS: HIV-infected subjects with low CD4 counts are prone to develop OE within the first few moths after beginning HAART. An inflammatory response to latent antigens due to the immune recovery might explain this fact.

3
UI - 20439436
AU - Tirelli U; Spina M; Gaidano G; Vaccher E; Franceschi S; Carbone A
TI - Epidemiological, biological and clinical features of HIV-related lymphomas in the era of highly active antiretroviral therapy.
SO - AIDS 2000 Aug 18;14(12):1675-88

4
UI - 21232614
AU - Ribera JM; Gimeno F; Campo E
TI - [A 33-year-old male infected by the human immunodeficiency virus with vomiting and abdominal pain of 15 days of duration]
SO - Med Clin (Barc) 2001 Mar 24;116(11):430-6
AD - Servicio de Hematologia y Unidad Hematooncologica. Hospital Universitari Germans Trias i Pujol. Badalona. Barcelona.

5
UI - 21313760
AU - Tarantul V; Nikolaev A; Hannig H; Kalmyrzaev B; Muchoyan I; Maximov V; Nenasheva V; Dubovaya V; Hunsmann G; Bodemer W
TI - Detection of abundantly transcribed genes and gene translocation in human immunodeficiency virus-associated non-Hodgkin's lymphoma.
SO - Neoplasia 2001 Mar-Apr;3(2):132-42
AD - Department of Viral and Cellular Molecular Genetics, Institute of Molecular Genetics, Moscow 123182, Russia. tarantul@img.ras.ru
Several novel, differentially transcribed genes were identified in one centroblastic and one immunoblastic HIV-associated B-cell non-Hodgkin's lymphoma (B-NHL) by subtractive cloning. In both lymphomas, we detected an upregulated transcription of several mitochondrial genes. In the centroblastic B-NHL, we found a high level transcription of nuclear genes including the interferon-inducible gene (INF-ind), the immunoglobulin light chain gene (IgL), the set oncogene, and several unknown genes. The data obtained on upregulated expression of the genes in human B-NHL of HIV-infected patients considerably overlap with those obtained earlier for the B-NHL of simian immunodeficiency virus-infected monkeys. In the centroblastic lymphoma, one transcript revealed a fusion of the 3'-untranslated region of the set gene and the C-terminal region of the IgL gene. This chimeric sequence was confirmed by a site-directed polymerase chain reaction performed with total cDNA and genomic DNA. The expected amplification product was obtained in both cases pointing to a genomic rearrangement. The IgL-set fusion sequence was not found in cDNA preparations and genomic DNA of the immunoblastic HIV-associated B-NHL. Further studies are necessary to determine whether these genes contribute to lymphoma development or can be used as therapeutic targets.