Información sobre riesgo, prevención, detección, síntomas, diagnosis, tratamiento y apoyo para el cáncer.
Información sobre el tratamiento del cáncer incluyendo quirúrgica, quimioterapia, radioterapia, estudios clínicos, terapia con protón, medicina complementaria avanzadas.
OncoLink se complace en ofrecer una amplia lista de lista completa de los agentes quimioterapéuticos más comúnmente usados??. Esta guía de referencia incluye información sobre la forma en que cada fármaco se administra, cómo funcionan, y los pacientes los efectos secundarios comunes pueden experimentar.
Maneras que los pacientes de cáncer y las personas que le cuidan puedan enfrentar el cáncer, los efectos secundarios, nutrición, cuestiones en general sobre el apoyo para el cáncer, duelo/decisiones sobre el termino de vida, y experiencias compartidas por sobrevivientes.
National Cancer Institute®
Ultima Vez Modificado: 21 de noviembre del 2001
UI - 21375554
AU - Dumanskii IuV; Shtutin SA; Zagorodnskii VF; Morgunova IN; Zaika AN;
TI - Stoliarova OIu [The complications in surgical treatment of gastric cancer in elderly and senile patients]
SO - Klin Khir 2001 Mar;(3):50-3
Causes of the perioperative complications occurrence in 736 elderly and senile patients, operated on for gastric cancer, were studied. It was established that the complications frequency and mortality were depended on the concomitant diseases presence, on the main disease complications, duration and volume of operation as well, but not from their age. The operation performance method and anesthesiological support perfection would permit to widen indications for the radical surgical intervention performance and raise the treatment of patients efficacy.
UI - 21338544
AU - Uchida K; Hayashi K; Kuramochi H; Takasaki K
TI - Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion.
SO - Int J Oncol 2001 Aug;19(2):341-6
AD - Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1 Kawadachou, Shinjuku-ku, Tokyo 162-8666, Japan.
Thymidylate synthase (TS) is the target enzyme of 5-fluorouracil (5-FU), and dihydropyrimidine dehydrogenase (DPD) is the key enzyme in the 5-FU catabolic pathway. We wanted to determine whether the TS and DPD mRNA expression levels of gastric and colorectal cancer patients would be affected by tegafur (futrafur:FT)-based chemotherapy and whether changes in their expression might be responsible for patient outcome. Thirty-five patients with resectable advanced primary gastric cancer and 36 patients with resectable advanced primary colorectal cancer were the subjects of this study. They all underwent neoadjuvant chemotherapy with protracted infusion of FT alone or FT plus low doses of cisplatin. The TS and DPD mRNA expression levels of endoscopic biopsy specimens before chemotherapy and surgical specimens after chemotherapy were measured by TaqMan reverse transcription-PCR assay using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as the internal standard. There was a significant difference in the DPD mRNA levels during chemotherapy in the colorectal cancers. Although the TS and DPD levels were unrelated to any conventional histopathological grade factors, colorectal cancer patients whose surgical specimens contained lower TS and DPD mRNA levels had longer disease-free intervals. The results of this study suggest that FT may affect DPD mRNA expression in colorectal cancer patients, that TS/DPD expression can be regarded as an independent prognostic factor, and that colorectal cancer patients with low TS and low DPD mRNA are candidates for FT-based adjuvant chemotherapy. In addition, quantitative analysis of the change in TS/DPD mRNA in surgical specimens during FT-based chemotherapy might be a more accurate means of predicting the post-operative disease-free interval of colorectal cancer patients than analysis of endoscopic specimens before chemotherapy. There also seems to be a relation between regulation of TS and DPD during FT chemotherapy. Elucidation of the mechanisms regulating TS and DPD mRNA expression might make it possible to predict sensitivity and/or toxicity to FT.
UI - 21340678
AU - Morant R
TI - Neoadjuvant and adjuvant chemotherapy of locally advanced stomach cancer.
SO - Onkologie 2001 Apr;24(2):116-21
AD - Zentrum fur Tumordiagnostik und Pravention, St. Gallen. email@example.com
Surgical treatment of locally advanced gastric carcinoma still results in unsatisfactory survival results. The addition of adjuvant chemotherapy has been shown to be of little value and is not considered standard practice. Preoperative chemotherapy, however, has a strong theoretical basis and may achieve significant tumor shrinkage and downstaging and thus allow complete resection of cancers previously judged by the responsible surgeon to be inoperable. However, it has not yet been demonstrated whether preoperative chemotherapy prolongs the survival of patients with potentially resectable cancers. Based on theoretical reasons, preoperative chemotherapy may be expected to be more efficient than postoperative chemotherapy. Various phase II trials have shown the feasibility of this approach, and encouraging results were found. Differing diagnostic methods, inclusion criteria, and chemotherapy regimens hamper direct comparisons between the trials. Several useful new drugs including taxanes and camptothecins and promising chemotherapy regimens incorporating continuously infused 5-fluorouracil have been introduced recently. Ongoing large randomized clinical trials (MAGIC trial, EORTC, SAKK) currently study the efficacy of preoperative chemotherapy in locally advanced gastric carcinoma. Copyright 2001 S. Karger GmbH, Freiburg
UI - 21367962
AU - Matsuo A; Watanabe A; Takahashi T; Futamura M; Mori S; Sugiyama Y;
TI - Takahashi Y; Saji S A simple method for classification of cell death by use of thin layer collagen gel for the detection of apoptosis and/or necrosis after cancer chemotherapy.
SO - Jpn J Cancer Res 2001 Jul;92(7):813-9
AD - Second Department of Surgery, Gifu University School of Medicine, Gifu 500-8705, Japan. firstname.lastname@example.org
To assess the efficacy of cancer chemotherapy, an important index is apoptosis of the target cells, which can usually be confirmed by electron microscopy (EM). We established a new experimental technique, whereby cancer cells (MKN45) were distributed in thin collagen gel as one or two cell layers, and cultured with anti-cancer drugs (5-FU and CDDP). The cells were stained with fluorescent Hoechst 33258 (Ho) and photographed, then with hematoxylin and eosin (H&E) and again photographed, and processed for EM. This approach allowed us to characterize the patterns of death of single cells in detail. There were six patterns of cell damage: two patterns of apoptosis, early peripheral condensation of chromatin and late apoptotic bodies, two patterns of necrosis, cytoplasmic swelling and washed-out images, and two further patterns, with morphological features of both apoptosis and necrosis, neither classified into necrosis nor apoptosis. The results show that cell death patterns can be mostly determined by combining observations of Ho and H&E-stained cells without the necessity for EM observation.
UI - 21262956
AU - Caporale A; Cosenza UM; Vestri AR; Giuliani A; Costi U; Galati G;
TI - Cannaviello C; Franchi F Has desmoplastic response extent protective action against tumor aggressiveness in gastric carcinoma?
SO - J Exp Clin Cancer Res 2001 Mar;20(1):21-4
AD - Dept. of Surgery Pietro Valdoni, Universita di Roma La Sapienza, Rome, Italy.
A clinical assessment of protective action of desmoplastic response by limiting tumor aggressiveness has been carried out in 171 patients with gastric carcinoma, surgically treated at the First Surgical Clinic of the University of Rome "La Sapienza" between 1988-1999. A univariate statistical analysis was performed using Kaplan-Meier method for: desmoplastic reaction, age, sex, histologic type, tumor size, stage, lymphonodal status and metastases. To determine the influence of these factors on prognosis, the Cox regression was applied. We found a significant association between desmoplastic reaction extent and presence or absence of metastases (p= 0.026), lymphonodal involvement (p = 0.05), stage (p = 0.036). In the univariate analysis, survival was significantly related to sex (p = 0.012), tumor size (p = 0.009), lymphonodal involvement (p = 0.000), metastases (p = 0.000), stage (p = 0.000), desmoplastic reaction extent (p = 0.05); age and histologic type showed no relationship (p = n.s.). The desmoplastic response extent is not a protective factor against tumor invasiveness in gastric carcinoma, on the contrary it may be considered a negative prognostic factor.
UI - 21271508
AU - Saito A; Noguchi Y; Yoshikawa T; Doi C; Fukuzawa K; Matsumoto A; Ito T;
TI - Tsuburaya A; Nagahara N Gastrectomized patients are in a state of chronic protein malnutrition analyses of 23 amino acids.
SO - Hepatogastroenterology 2001 Mar-Apr;48(38):585-9
AD - First Department of Surgery, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004 Japan. email@example.com
BACKGROUND/AIMS: Malnutrition is one of the major postoperative complications of radical subtotal or total gastrectomy for gastric cancer. This study was conducted to clarify the nutritional consequences of radical gastrectomy with respect to protein metabolism. METHODOLOGY: To evaluate the nutritional status and the abnormalities in protein metabolism in such cases, serum concentrations of 23 amino acids were measured by high performance liquid chromatography in 40 patients who had undergone either subtotal (n = 20) or total (n = 20) gastrectomy more than 6 months prior to this analysis. RESULTS: Serum concentrations of total amino acids and nonessential amino acids were the same between gastrectomized patients and healthy controls (n = 50). However, concentrations of essential amino acids, essential amino acid/nonessential amino acid and branched-chain amino acid/total amino acid ratios were significantly lower in patient groups than in normal controls. Each essential amino acid was decreased and concentrations of glutamate and citrulline were increased in both patient groups compared with controls. The major differences between patients with subtotal and total gastrectomies included an increased ornithine and a decreased arginine concentration in patients with subtotal gastrectomy. CONCLUSIONS: These changes suggest that malabsorption of protein from the intestinal tract causes persistent proteolysis in the skeletal muscle for long periods of time after surgery in these patients and that changes in ornithine and citrulline levels may reflect more severe alterations in those with total gastrectomy.
UI - 21271511
AU - Sakaguchi T; Sawada H; Yamada Y; Fujimoto H; Emoto K; Takayama T; Ueno
TI - M; Nakajima Y Indication of splenectomy for gastric carcinoma involving the proximal part of the stomach.
SO - Hepatogastroenterology 2001 Mar-Apr;48(38):603-5
AD - First Department of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, 634-8522, Japan.
BACKGROUND/AIMS: The role of splenectomy in the surgical management of gastric carcinoma is controversial and there is no consensus of opinion regarding the therapeutic value of splenectomy. The aim of this study was to search for possible metastasis to lymph nodes in the splenic hilum or along the splenic artery to avoid unnecessary splenectomy and to determine its indication. METHODOLOGY: The clinical records of 204 patients who underwent total gastrectomy combined with splenectomy for gastric carcinomas involving the proximal part of the stomach were analyzed. RESULTS: The incidence of nodal involvement to the splenic hilum and/or along the splenic artery was 49 (24.0%) of 204 gastric carcinomas involving the proximal part of the stomach that underwent combined gastrectomy and splenectomy. The characteristics of gastric carcinoma with metastasis to these nodes included a larger tumor, deeper penetration (T3, 4 tumors), a number of lymph node metastasis, and infiltrative type. In T2 cases, all the tumors with cancerous involvement to these nodes showed intraoperative gross serosal change). When the tumor size was less than 40 mm, nodal metastatic rate to the splenic hilum and/or along the splenic artery was very low. CONCLUSIONS: In conclusion, splenectomy should be conducted in T2 cases with gross serosal change and T3, 4 cases. With regard to tumor size, in the cases with a tumor whose size was less than 40 mm, it is possible to preserve the spleen in most cases. In the near future, splenectomy should be clarified precisely by randomized trials in advanced gastric carcinoma.
UI - 21381292
AU - Feldman RA
TI - Review article: would eradication of Helicobacter pylori infection reduce the risk of gastric cancer?
SO - Aliment Pharmacol Ther 2001 Jun;15 Suppl 1():2-5
AD - The Royal London Hospital, Whitechapel Road, London E1 1BB, UK. firstname.lastname@example.org
This article reviews the data on the epidemiology of gastric cancer, to determine if treatment of an asymptomatic individual can be justified. It reviews retrospective and prospective case-control studies of gastric cancer in Italy and other countries. Mucosa-associated lymphoid tissue lymphoma is associated with Helicobacter pylori infection. The risk of noncardia gastric cancer is higher (4-fold or greater) in those with H. pylori infection. Although no studies have shown prevention following treatment, eradication of asymptomatic H. pylori infection in an individual in the age group 40 or lower may be expected to reduce the risk of gastric cancer.
UI - 21424853
AU - Waller MB
TI - Evaluation and management of gastric adenocarcinoma.
SO - Nurs Clin North Am 2001 Sep;36(3):543-52, xi
AD - Department of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. email@example.com
This article reviews the epidemiology, cause, and current staging of gastric adenocarcinoma. An in-depth discussion regarding patient assessment and treatment options is presented. Advanced disease management and clinical trials are reviewed.
UI - 21464091
AU - Arai K; Iwasaki Y; Takahashi T
TI - [Repeated intraperitoneal chemotherapy for peritoneal dissemination from gastric carcinoma]
SO - Gan To Kagaku Ryoho 2001 Sep;28(9):1257-61
AD - Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.
Repeated intraperitoneal chemotherapy (RIC) via an i.p. port system was carried out in 16 patients with peritoneal dissemination (P1) and in 10 with positive washing cytology (P0.CY1) from gastric carcinoma. CDDP dissolved in 500-1,000 ml of physiological saline solution was periodically administered via the i.p. port system. The change of washing cytology (CY), which was obtained from i.p. port, was examined before each administration as a indicator of the response. The average number of administrations was 5.7 and the average total dose was 301.7 mg. As a result, a negative change of CY after RIC was found in 74% of patients, and also more than 80% of the response occurred within three administrations. The prognosis tended to be better in P0.CY1 patients than in P1 patients. In particular, the median survival time of the CY responders markedly improved as compared with non-responders (27.8 months versus 7.1 months). Although diarrhea and anorexia of grade 3 developed once in each patient, serious toxicities were not found. In conclusion, we consider RIC to be an effective therapy for P0.CY1 among cases with peritoneal dissemination from gastric carcinoma.
UI - 21458879
AU - Boku N; Ohtsu A; Nagashima F; Muto M; Shinkai T; Yoshida S
TI - Retrospective study of hyponatremia in gastric cancer patients treated with a combination chemotherapy of 5-fluorouracil and cisplatin: a possible warning sign of severe hematological toxicities?
SO - Jpn J Clin Oncol 2001 Aug;31(8):382-7
AD - Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan. firstname.lastname@example.org
BACKGROUND: Some anti-neoplastic agents induce hyponatremia. The relationship between hyponatremia and other toxicities in gastric cancer patients treated with 5-fluorouracil and cisplatin (FP) was investigated retrospectively to clarify its clinical significance. METHODS: The subjects were 50 advanced gastric cancer patients treated with FP. Patients' performance status, oral intake, nausea/vomiting, diarrhea, fever, urine volume, presence of ascites or pleural effusion, laboratory data and administration of diuretics, corticosteroid and contents and volume of hydration before and during the first 5 days after chemotherapy were reviewed. RESULTS: The serum sodium level decreased after initiation of chemotherapy in all patients and the lowest level (nadir) was most frequently observed on day 8 (range, days 2-14), which preceded hematological toxicities. In 10 patients (20%) the nadir of serum sodium was lower than 125 mEq/l. We classified these 10 patients as a low-sodium group and the others into a normal-sodium group. Six (60%) and seven (70%) of the 10 patients in the low-sodium group had complications with grade 3 or 4 leukopenia and thrombocytopenia, whereas only one (3%) and two (5%) were seen in the normal-sodium group (p < 0.0001). Stomatitis and diarrhea were also slightly more severe in the former than the latter group. With respect to sensitivity and probability, receiver operating characteristic curves showed the nadir ((> or = ) or <125 mEq/l) of the serum sodium level was the best marker for both leukopenia and thrombocytopenia. CONCLUSION: Hyponatremia after initiation of chemotherapy with FP may be a warning sign of subsequent severe hematological toxicity.
UI - 21383842
AU - Zherlov GK; Koshel' AP; Efimov NP; Autlev KM
TI - [Proximal resection of the cardiac portion of the stomach]
SO - Khirurgiia (Mosk) 2001;(4):17-21
From 1989 to 1999 75 proximal resections of the stomach were performed. There were two variants of operation. In the first variant, invaginative valve from submucous-mucous membrane of the esophagus and the stomach was formed in the zone of gastroesophageal anastomosis. In the second variant, for prevention of anastomotic sutures eruption late after surgery and prophylaxis of valve expanding, duplication of muscular membrane on esophagus was formed. 58 patients were operated by the first variant, 17--by second variant. Postoperative lethality was 2.7% (1 patient died after operation of the first variant, 1 patient--after the second variant). In early postoperative period the complications were revealed in 8 (10.7%) patients. There was no insufficiency of anastomotic sutures. Mean hospital stay after operation was 14.7 +/- 3.5 bed days. Reflux-esophagitis of severe degree in remote period after operation was seen in 1 (1.3%) patient, catarral--in 4 (5.3%), all the patients were operated by the first variant.
UI - 21290095
AU - de Manzoni G; Pasini F; Bonfiglio M; Di Leo A; Pedrazzani C; Borzellino
TI - G; Zerman G; Tasselli S; Castelli A [Results of the surgical treatment of primary gastric lymphoma]
SO - Chir Ital 2001 Jan-Feb;53(2):175-80
AD - Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Ia Divisione Clinicizzata di Chirurgia, Universita degli Studi di Verona.
The aim of the study was to verify the long term results obtained in primary gastric lymphoma with a strategy consisting in surgery as 1999, 44 patients with histologically proven primary gastric lymphoma underwent surgical treatment in the First Department of General Surgery of the University of Verona. Tumours were staged according to the Ann Arbor classification and divided, according to the Kiel classification, into high- and low-grade lymphoma. Patients received adjuvant chemotherapy depending on the grade of malignancy and/or completeness of resection. Of the 44 patients, 40 (90.9%) underwent curative resections, i.e. with complete macroscopic and microscopic tumour removal (R0), consisting in total gastrectomy in 34 cases and subtotal gastrectomy in 6. Twenty-five of 40 patients had stage IE and 15 stage IIE tumours. Adjuvant chemotherapy was given to 33 patients (30 high-grade lymphomas and 3 low-grade lymphomas with N2 metastases). The overall cumulative 10-year survival rate in patients who underwent R0 resection was 79% without any significant differences in 10-year survival between patients with high- and low-grade malignancy (both 79%; P = 0.582) or between patients with or without lymph node metastases (91% and 70%, respectively; P = 0.426). In conclusion, the present investigation suggests that surgery yields prolonged complete remission in a high percentage of patients affected by gastric lymphoma irrespective of histopathologic grade of the disease and nodal involvement.
UI - 21330632
AU - Miwa K
TI - [Optimal nodal dissection for early gastric cancer]
SO - Nippon Geka Gakkai Zasshi 2001 Jun;102(6):484-9
AD - Department of Surgery II, School of Medicine Kanazawa University, Kanazawa, Japan.
Extensive lymphadenectomy (D2) in 295 patients with early gastric cancer (EGC) resulted in a significantly lower 10-year recurrence rate than limited lymph node dissection (D1) in 97 patients (2.1% vs. 11.9%, p < 0.005). Among node-positive patients, the recurrence rate following D2 was significantly lower than that after D1 (12.5% vs. 44.4%, p < 0.02). Among node-negative patients, there was no difference in recurrence rate between two groups (0.6% vs 3.3%, p < 0.2). These observations suggest that there are two optimal methods of node dissections in EGC surgery based on nodal status. The sentinel node concept is important to understand nodal status. In 1993, we developed intraoperative endoscopic lymphatic mapping with 2% patent blue to demonstrate the lymphatic basins in EGC. Frozen sections of the blue nodes in 203 patients had a high predictive value for nodal metastasis, with a sensitivity of 89%, specificity of 100%, and accuracy of 98%. Four false-negative cases had clinical metastasis, which was diagnosed at surgery. In 34 of 35 patients, metastatic nodes were located along the lymphatic basins. Among them, 15 patients had metastasis only in the sentinel lymph nodes. Of 5 gastric lymphatic basins, 42% of the patients had involvement of one, 47% 2, and 12% 3. These results show that each EGC has its own lymphatic basins in which metastasis can develop. The more numbers of the sections there are, the higher the likelihood of nodal metastasis. This means that each frozen section slice carries the risk of being false negative. Therefore we should always dissect the lymphatic basins even in cases with no sentinel node metastasis. In addition, patients with sentinel nodes containing metastasis should be treated with the D2 procedure.
UI - 21384118
AU - Jagoditsch M; Pertl A; Jatzko GR; Denk H; Stettner HM
TI - [Long-term outcome of stomach carcinoma achieved in an Austrian standard hospital with an oncologic focus]
SO - Chirurg 2001 Jul;72(7):822-31
AD - Chirurgische Abteilung, Krankenhaus der Barmherzigen Bruder St. Veit/Glan, Lehrkrankenhaus der medizinischen Fakultat, Universitat Wien, Osterreich.
INTRODUCTION: Although two large prospective and randomized planned European studies failed to show any benefit of radical D2 lymphadenectomy for gastric cancer, the value of radical lymphadenectomy is still a matter of controversy. METHODS: A radical surgical approach principally using D2, D3 lymphadenectomy, as defined by the Japanese Research Society for Gastric Cancer, has been prospectively performed surgically treated for potential cure between 1984 and 31 December, 1998. Clinical, histopathological and surgical factors were evaluated for their influence on long-term survival by means of univariate and multivariate analysis. RESULTS: Tumor-specific 5- and 10-year survival rates for all patients were 58.5% and 57.5% for patients who underwent tumor resection 59% and 58%. For operated patients upon with the aim of achieving cures, the tumor-specific 5- and 10-year survival rates were 63.3% and 62.2% and the median survival time was more than 144 months. Postoperative hospital mortality was 7.7%, 4.6% for R0 resected patients, 8.6% for R1,2 resected patients and 21.3% for those undergoing palliative procedures. Multivariate analysis using the Cox model identified an age older than 65, total gastrectomy as well as high pN- and pT category as detrimental factors with an independent influence on survival. CONCLUSION: After updating the long-term results of gastric cancer, as already published earlier, it is impressively obvious that also in a European setting of gastric cancer patients, with a presupposed appropriate surgical technique and experience, very constant cure rates are achievable with comparatively low mortality and morbidity.
UI - 21396285
AU - Tokunaga A; Onda M; Yoshiyuki T; Onodera H; Fujita I; Okuda T; Mizutani
TI - T; Kiyama T; Kato S; Matsukura N; Takano T; Ogawa R Biochemical assessment of cardiac function in patients undergoing surgery for gastric cancer.
SO - J Nippon Med Sch 2001 Aug;68(4):351-2
AD - Department of Surgery (I), Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan. email@example.com
UI - 21429009
AU - Ell C; Gossner L; May A
TI - [Early carcinoma of the oesophagus, stomach and large intestine--endoscopic therapy instead of surgery]
SO - Dtsch Med Wochenschr 2001 Sep 7;126(36):994-5
UI - 21429010
AU - Willis S; Schumpelick V
TI - [Endoscopic mucosal resection instead of surgical intervention for early carcinoma of the oesophagus, stomach and small intestine]
SO - Dtsch Med Wochenschr 2001 Sep 7;126(36):996
UI - 21438127
AU - Gaspar MJ; Arribas I; Coca MC; Diez-Alonso M
TI - Prognostic value of carcinoembryonic antigen, CA 19-9 and CA 72-4 in gastric carcinoma.
SO - Tumour Biol 2001 Sep-Oct;22(5):318-22
AD - Department of Clinical Chemistry, University Hospital Principe de Asturias, Alcala de Henares, Madrid, Spain. firstname.lastname@example.org
The prognostic value of preoperative serum levels of carcinoembryonic antigen (CEA), CA 19-9 and CA 72-4 tumor markers was investigated in patients with gastric cancer. Eighty-two patients who underwent surgical resection of gastric cancer were entered in the study. Correlation analyses showed that CA 72-4 was more frequently positive in patients with advanced tumors (p = 0.04), lymph node invasion (p = 0.02), liver metastasis (p = 0.02) and peritoneal involvement (p = 0.03). CA 19-9 was more frequently positive in patients with advanced tumors (p = 0.01) and with serosal (p = 0.04), lymph node (p = 0.008) and peritoneal involvement (p = 0.02). CEA was more frequently positive in patients with liver metastasis (p = 0.03). Low 3-year cumulative survival was significantly associated with elevated serum levels of CA 72-4 (p = 0.004), CA 19-9 (p = 0.001) and CEA (p < 0.001). Age, tumor stage and CA 72-4 provided prognostic information in the multivariate analysis. Patients with elevated serum levels of CA 72-4 showed a 4.2 times higher risk of death than patients with low levels of the marker. Our results suggest that CA 72-4 has prognostic value in gastric cancer, and patients with a high preoperative serum level of CA 72-4 have a greater risk of death due to gastric cancer. Copyright 2001 S. Karger AG, Basel
UI - 21300164
AU - Lee KY; Noh SH; Hyung WJ; Lee JH; Lah KH; Choi SH; Min JS
TI - Impact of splenectomy for lymph node dissection on long-term surgical outcome in gastric cancer.
SO - Ann Surg Oncol 2001 Jun;8(5):402-6
AD - Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
BACKGROUND: In the treatment of gastric cancer, splenectomy is performed for effective lymph node dissection around the splenic artery and splenic hilum. The purpose of this study was to clarify the long-term outcome of splenectomy in the treatment of gastric cancer. METHODS: The effect of splenectomy on recurrence and prognosis was examined in a retrospective analysis of 665 patients who had undergone curative total gastrectomy for gastric carcinoma from 1987 to 1996. The risk factors associated with recurrence and prognosis were investigated by univariate and multivariate analysis. RESULTS: The splenectomy group showed more advanced lesions and a higher recurrence rate than the spleen-preserved group. However, after adjusting for the TNM (tumor, node, metastasis) stage, there was no significant difference in recurrence rate and pattern between the two groups. Logistic regression analysis revealed that gross type, serosal invasion, and nodal metastasis were independent risk factors for recurrence while splenectomy was not. When comparing patients with the same TNM (tumor, node, metastasis) stages, no significant difference in the 5-year survival rates was apparent. Multivariate analysis demonstrated that age, serosal invasion, and nodal metastasis were independent prognostic factors whereas splenectomy was not. CONCLUSIONS: These data suggest that splenectomy for lymph node dissection in gastric cancer is not effective regarding long-term patient prognosis.
UI - 21312263
AU - Watanabe Y; Sato M; Kikkawa H; Yoshida M; Shiozaki T; Kotani T; Nezu K;
TI - Kawachi K Intragastric endoscopic mucosal resection through a temporary gastrostomy for early gastric cancer: usefulness of Buess-type endoscope.
SO - Eur J Surg 2001 May;167(5):362-5
AD - Department of Surgery II, Ehime University, Shigenobu, Japan.
OBJECTIVE: To assess the feasibility of cure of early gastric cancer by the endoscopic procedure done through a temporary gastrostomy and to use it to treat patients with various severe complications. DESIGN: Prospective study. SETTING: University hospital, Japan. SUBJECTS: Four patients who required gastric mucosal resection for early gastric cancer. MAIN OUTCOME MEASURES: Ease of the procedure, cure rate, safety under epidural anaesthesia, and outcome. RESULTS: All patients had the procedure under epidural anaesthesia without pain or complaints during operation. Mean operation time was 120 minutes (60-200). Histological examination showed that the surgical margin was free of tumour in 3 of the cases. One patient who had microscopic invasion of lymph nodes subsequently underwent second-look conventional gastrectomy with lymphadenectomy. Postoperative recovery was rapid, and all patients were discharged from the hospital uneventfully. CONCLUSION: This organ-preserving procedure enables good visualisation of the tumour and is useful even for high-risk patients.
UI - 21371224
AU - Wang Y; Yao Z; Huang X
TI - [Clinical study on preventing and treating chemotherapy induced nausea and vomiting using supplemented Inula-Ochrae Decoction]
SO - Zhongguo Zhong Xi Yi Jie He Za Zhi 1998 May;18(5):273-5
AD - Nantong First People's Hospital, Nantong, Jiangsu 226001.
OBJECTIVE: To observe supplemented Inula-Ochrae Decoction (SIOD) in preventing and treating nausea and vomiting induced by chemotherapy for patients with malignant tumour. METHODS: Seventy-two patients were divided into two groups, the patients in test group took SIOD and in control group using ondensetron, and the efficacy of SIOD in preventing and treating chemotherapy induced nausea and vomiting were studied prospectively with self-intersection approach. RESULTS: The effective rate of treating vomiting due to chemotherapy with DDP and without DDP in the test group was 92.7% and 93.5% respectively, and was higher than that in the control group 87.8% and 87.1%, the difference was insignificant statistically (P > 0.05). CONCLUSIONS: The prescription SIOD could prevent and treat effectively chemotherapy induced nausea and vomiting without any toxic and side effects, and is inexpensive with high efficacy for clinical use.
UI - 21441567
AU - Yoshikane H; Sakakibara A; Hidano H; Niwa Y; Goto H; Yokoi T
TI - Piecemeal endoscopic aspiration mucosectomy for large superficial intramucosal tumors of the stomach.
SO - Endoscopy 2001 Sep;33(9):795-9
AD - Dept. of Internal Medicine, Handa City Hospital, Handa, Japan. email@example.com
BACKGROUND AND STUDY AIMS: As endoscopic techniques continue to develop, endoscopic mucosal resection is increasingly being used in the treatment of intramucosal gastric tumors. The aim of this study was to explore the feasibility of piecemeal endoscopic aspiration mucosectomy for large superficial intramucosal tumors of the stomach. PATIENTS AND METHODS: The study group consisted of five consecutive patients with large superficial intramucosal tumors of the stomach, 4 cm or more in diameter. Piecemeal endoscopic aspiration mucosectomy using a cap-fitted panendoscope was carried out. The initial resection was undertaken at the oral side of the lesion. Subsequent resections were carried out along the anal margin of the previous resection site, until the marks around the boundary of the tumor completely disappeared. RESULTS: The shape of the tumors was slightly elevated in four cases and slightly depressed in one. The mean diameter of the tumors was 4.8 cm. The diameters of the resected specimens ranged from approximately 1.0 cm to 2.3 cm. The numbers of piecemeal resection procedures needed per lesion ranged from five to 18 (mean 11). The visual field was well ensured by the cap, and the tumors were macroscopically completely resected without any complications in all patients. The final histological diagnoses in the specimens were adenoma in one case and mucosal carcinoma in adenoma in four. One patient had residual or recurrent tumor, and received full treatment with additional endoscopic procedures. CONCLUSIONS: Piecemeal endoscopic aspiration mucosectomy is a simple and very useful technique for treating large superficial intramucosal tumors of the stomach.
UI - 21179635
AU - Santangelo M; Vescio G; Sommella L; Battaglia M; Valente A; Sammarco G;
TI - Bossa F; Triggiani E [Extended total gastrectomy: indications in the 3rd millennium]
SO - Minerva Chir 2001 Feb;56(1):1-6
AD - Istituto di Chirurgia Generale e dei Trapianti, Facolta di Medicina e Chirurgia, Universita degli Studi Magna Grecia, Catanzaro, Italy. firstname.lastname@example.org
BACKGROUND: Total extended gastrectomy (TEG) is indicated in the treatment of gastric cancer for necessity or to achieve an oncologic radicality. By this surgical treatment the stomach and other organs or a part of them involved by primitive tumor are removed. METHODS: The authors report a study about 15 patients, out of 116 cases of gastric cancer, operated by TEG between 1990-1998. The middle-age of this patients was 63 years (range 45-76) and their general conditions were good in 9 cases and not-good in 6. The postoperative total parenteral nutrition (TPN) was carried out in all the patients, while preoperatively only in the most compromised patients. The surgical treatments were: 2 TG (total gastrectomy)+splenecomy; 3 TG+splenectomy+pancreatic resection; 4 TG+splenectomy+pancreatic resection+distal esophageal resection; 1 TG+distal esophageal resection; 2 TG+atypic hepatic resection; 1 TG+ atypic hepatic resection+duodenum resection; 2 TG+large intestine resection. While 10 patients were operated on to obtain radicality, 5 patients had a palliative treatment. RESULTS: There was not perioperative mortality, but we have observed: one dehiscence of the duodenal stump and one pancreatic fistula treated with conservative therapy; one left subfrenic abscess treated with surgical therapy. The survival has been higher in the patients treated with radicality. On the basis of these cases, the authors consider: 1) the possibility to obtain radicality by TEG; 2) the gastric localizations more often associated to extravisceral neoplastic localization; 3) the role of extensive lymph node resection (III and IV level) to obtain oncological radicality or neoplastic reduction. CONCLUSIONS. On the basis of their personal experience and related literature, the authors conclude that TEG is indicated to: 1) obtain a better lymphadenectomy; 2) obtain an oncologic radicality; 3) reduce the neoplastic mass in order to facilitate adjuvant therapy; 4) avoid or treat neoplastic complications; 5) improve the quality of life.
UI - 21325275
AU - You WC; Chang YS; Heinrich J; Ma JL; Liu WD; Zhang L; Brown LM; Yang CS;
TI - Gail MH; Fraumeni JF Jr; Xu GW An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels, and toxicity.
SO - Eur J Cancer Prev 2001 Jun;10(3):257-63
AD - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD 20892, USA. email@example.com
Gastric cancer is the second most frequent cause of death from cancer in the world and the leading cause of death from cancer in China. In inhibit the progression of precancerous gastric lesions in Linqu County, Shandong Province, an area of China with one of the world's highest rates of gastric cancer. Treatment compliance was measured by pill counts and quarterly serum concentrations of vitamin C, vitamin E and S-allyl cysteine. In 1999, toxicity information was collected from each trial participant to evaluate treatment-related side-effects during the trial. Compliance rates were 93% and 92.9% for 39 months of treatment with the vitamins/mineral and garlic preparation, respectively. The means for serum concentrations of vitamins C and E were 7.2 microg/ml and 1695 microg/dl among subjects in the active treatment groups compared with 3.1 microg/ml and 752 microg/dl among subjects in the placebo treatment group, respectively. No significant differences in side-effects were observed between the placebo treatment group and the vitamins/mineral and garlic preparation treatment groups during the 39-month trial period.
UI - 21538324
AU - Uehara S; Murabayashi K; Kusta T; Takahashi K; Ogawa T; Onishi H;
TI - Saegusa S; Noda N; Okanami Y; Nakamura I [Neoadjuvant chemotherapy for advanced gastric cancer with para-aortic lymph node metastasis]
SO - Gan To Kagaku Ryoho 2001 Oct;28(10):1413-8
AD - Dept. of Surgery, Yamada Red Cross Hospital.
Neoadjuvant chemotherapy was applied to patients with advanced gastric cancer and confirmed para-aortic lymph node metastasis. Subjects were 7 patients. The response to the neoadjuvant chemotherapy was a PR in 5 cases, MR in 2 cases for the primary lesion and CR in 2 cases PR in 5 cases for the para-aortic lymph node metastasis. The grades of histological response assessed on the resected specimen were Grade 0 in three cases, Grade 1a in one, Grade 1b in one and Grade 2 in two. While there was no significant difference in survival rate between patient groups with and without neoadjuvant chemotherapy, the 2-year survival rate in patients with neoadjuvant chemotherapy was a good 42.9%, compared with 10% in patients groups without neoadjuvant chemotherapy. It is concluded that a better prognosis can be expected for advanced gastric cancer patients with neoadjuvant chemotherapy.
UI - 21538325
AU - Kamata T; Hayashi Y; Minatoya G; Michiwa Y; Onishi I; Takeda T; Koyasaki
TI - N; Kanno M [A pilot study of low-dose TS-1 and cisplatin combination chemotherapy for advanced gastric cancer]
SO - Gan To Kagaku Ryoho 2001 Oct;28(10):1419-22
AD - Dept. of Surgery and Gastroenterology, Keiju Medical Center.
TS-1, a novel oral formation of 5-fluorouracil, consists of tegafur (5-FU), CDHP and Oxo. Low-dose cisplatin (CDDP) and TS-1 was evaluated in 12 patients with advanced or recurrent gastric cancer. CDDP was given biweekly at a dose of 15 mg/m2 infused for 30 minutes, and 80 mg/body of TS-1 was orally administered as many times as possible. The response rate was 41.7%. Median survival time was 13.3 months. In one case, an adverse reaction of grade 3 leucopenia was observed. Thus, thought it is necessary to watch for leucopenia, this chemotherapy could well be effective for patients with advanced or recurrent gastric cancer.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
Endocrine System Cancers
Head and Neck Cancers
Urinary Tract Cancers
Bone Marrow Transplants
General Treatment Concerns
Newly Diagnosed Patients
Causes and Prevention
Legal and Financial Information for Patients
Cancer Resource List
Resources for Young Adults