Posted Date: Aug 21, 2002
This patient summary on nutrition is adapted from the summary written forhealth professionals by cancer experts. This and other credible informationabout cancer treatment, screening, prevention, supportive care, and ongoingclinical trials, is available from the National Cancer Institute. Cancer andits treatment can lead to malnutrition, a common problem in cancer patients. This brief summary describes the effects of cancer and its therapy onnutrition, as well as methods for maintaining nutrition in cancer patients.
Cancer patients frequently have problems getting enough nutrition. Malnutrition is a major cause of illness and death in cancer patients. Malnutrition occurs when too little food is eaten to continue the body'sfunctions. Progressive wasting, weakness, exhaustion, lower resistance toinfection, problems tolerating cancer therapy, and finally, death may result.
Anorexia (the loss of appetite or desire to eat) is the most common symptom inpeople with cancer. Anorexia may occur early in the disease or later, when thetumor grows and spreads. Some patients may have anorexia when they arediagnosed with cancer; and almost all patients who have widespread cancer willdevelop anorexia. Anorexia is the most common cause of malnutrition anddeterioration in cancer patients.
Cachexia is a wasting syndrome characterized by weakness and a noticeablecontinuous loss of weight, fat, and muscle. Anorexia and cachexia often occurtogether. Cachexia can occur in people who are eating enough, but who cannotabsorb the nutrients. Cachexia is not related to the tumor size, type, orextent. Cancer cachexia is not the same as starvation. A healthy person'sbody can adjust to starvation by slowing down its use of nutrients, but incancer patients, the body does not make this adjustment.
Some cancer patients may die of the effects of malnutrition and wasting.
Many malnutrition problems are caused directly by the tumor. Tumors growing inthe stomach, esophagus, or intestines can cause blockage, nausea and vomiting,poor digestion, slow movement through the digestive system, or poor absorptionof nutrients. Cancer of the ovaries or genital and urinary organs can causeascites (excess fluid in the abdomen), leading to feelings of early fullness,worsening malnutrition, or fluid and electrolyte imbalances. Pain caused bythe tumor can result in severe anorexia and a decrease in the amount of foodsand liquids consumed. Central nervous system tumors (such as brain cancer) cancause confusion or sleepiness; patients may lose interest in food or forget toeat.
Changes in the body's metabolism can also cause nutritional problems. Tumorcells often convert nutrients to energy in different, less efficient ways thando other cells.
Tumors may produce chemicals or other products that can cause anorexia andcachexia. For example, tumors can produce a substance that changes a person'ssense of taste, so that the patient does not want to eat. Tumors can affectthe receptors in the brain that tell the stomach if it is full. Tumors canalso produce hormone substances, which can change the amount of nutrientseaten, the way they are absorbed, and the way they are used by the body.
Nutrition problems can be caused by cancer therapies and their side effects. The treatment may have a direct effect, such as poor protein and fat absorptionafter certain types of surgeries, or an indirect effect, such as an increasedneed for energy due to infection and fever. Severe malnutrition is defined intwo ways: as an increased risk of illness and/or death and as a defined amountof weight loss over a specified amount of time.
Head and neck surgery may cause chewing and swallowing problems or may causemental stress due to the amount of tissue removed during surgery. Surgery tothe esophagus may cause stomach paralysis and poor absorption of fat. Poorabsorption of protein and fat, dumping syndrome (rapid emptying of the stomach)with low blood sugar, and early feelings of fullness may follow stomachsurgery. Surgery to the pancreas may also cause poor protein and fatabsorption, poor absorption of vitamins and minerals, or diabetes. Small boweland colon surgery may cause poor absorption of protein and fat, vitamin andmineral shortages, diarrhea, and severe fluid and electrolyte losses. Surgeryto the urinary tract can cause electrolyte imbalances. Other side effects ofsurgery that can affect nutrition include infection, fistulas (holes betweentwo organs or between an organ and the surface of the body), or short-bowelsyndrome. After a colostomy, patients may decrease the amount they eat anddrink.
Chemotherapy can cause anorexia, nausea and/or vomiting, diarrhea orconstipation, inflammation and sores in the mouth, changes in the way foodtastes, or infections. Symptoms that affect nutrition and last longer than 2weeks are especially critical. The frequency and severity of these symptomsdepends on the type of chemotherapy drug, the dosage, and the other drugs andtreatments given at the same time. Nutrition may be seriously affected when apatient has a fever for an extended period of time since fevers increase thenumber of calories needed by the body.
Radiation therapy to the head and neck can cause anorexia, taste changes, drymouth, inflammation of the mouth and gums, swallowing problems, jaw spasms,cavities, or infection. Radiation to the chest can cause infection in theesophagus, swallowing problems, esophageal reflux (a backwards flow of thestomach contents into the esophagus), nausea, or vomiting. Radiation to theabdomen or pelvis may cause diarrhea, nausea and vomiting, inflammation of theintestine or rectum, or fistula formation. Radiation therapy may also causetiredness, which may lead to a decrease in appetite and a reduced desire toeat. Long-term effects can include narrowing of the intestine, chronicinflamed intestines, poor absorption, or blockage of the gastrointestinaltract.
Immunotherapy (for example, biological response modifier therapy) can causefever, tiredness, and weakness, and can lead to loss of appetite and anincreased need for protein and calories.
Eating is an important social activity. Anorexia and food avoidance lead tosocial isolation when people cannot be with others during meal times. Manymental and social factors can affect a person's desire and willingness to eat. Depression, anxiety, anger, and fear are often felt by cancer patients and canlead to anorexia. Feeling a loss of control or helplessness can also reducethe desire to eat. Refusing to eat even when begged to eat by family, friends,and care givers may be one way a patient (who may not feel able to refusetreatment) feels able to have some control in life. Learned food dislikes mayalso cause less eating or drinking, nausea, and/or vomiting. People who havean unpleasant experience after eating a certain food may avoid that food in thefuture.
Factors such as living alone, an inability to cook or prepare meals, or aninability to walk to the kitchen because of physical disabilities may lead toeating problems. A social worker or nurse can evaluate the patient's home andrecommend changes to help improve eating habits.
Diagnosing the cancer and treating it often means that the patient has to spendmuch time away from home and the normal routine, including having meals. Favorite foods may not be available in the hospital, or may not be toleratedwell because of treatment side effects. For example, a person who enjoys hot,spicy food and has inflammation of the esophagus may not like the taste ofbland food and may eat very little. Changes in taste can affect a person'sappetite and desire for food.
The less a cancer patient eats, the weaker he or she becomes, and the more itseems that the cancer is progressing. This wasting is a constant reminder tothe patient, family, and care givers of the cancer diagnosis and expected pooroutcome. This can affect quality of life, social participation, and attitude. Also, with continued wasting, and the resulting tiredness, the personsocializes even less. Since food and eating have such an important role insociety, the inability to eat well and the consequences of inadequate nutritionisolate the patient even more.
Exercise (such as walking or mild aerobics) has a positive effect on thepatient's sense of well-being, alleviating nausea and vomiting, and thepatient's ability to eat. Patients who must have artificial feeding methodsmay show depression, changes in body image, and stress caused by feeding tubesand equipment. To cancer patients, problems with nutrition are more importantto their sense of well-being than their sexuality and their ability to remainemployed.
The patient's medical history and physical examination are the most importantfactors in determining the nutritional status of a cancer patient. Thisassessment should include a weight history; any changes in eating and drinking;symptoms affecting nutrition (including anorexia, nausea, vomiting, diarrhea,constipation, inflammation and sores in the mouth, dry mouth, taste/smellchanges, or pain); medications that affect eating and the way the body usesnutrients; other illnesses or conditions that could affect nutrition ornutritional treatment; and the patient's level of functioning. The cancerpatient should be asked about changes in eating and drinking compared to whatis normal for him or her, and how long this change has lasted. The physicalexamination should look for weight loss, loss of fat under the skin, musclewasting, fluid collection in the legs, and the presence of ascites.
Finding out how much the person likes to eat, as well as what he or she likesto eat, can help when making changes to a cancer patient's diet. Knowing thepatient's specific food likes, dislikes, and allergies is also helpful.
The type of treatment needed to improve a cancer patient's nutrition is chosenbased on the following factors:
Keeping the body looking well and maintaining good nutrition can help thecancer patient feel and look better and help improve his or her dailyfunctioning. It may also help patients tolerate cancer therapy. The type oftreatment chosen for nutritional problems depends on the cause of the problems. Problems caused by the tumor may end when the tumor responds to therapy.
Food odor frequently causes anorexia in cancer patients. Patients withanorexia should avoid odors caused by food preparation. Cancer patients may beable to tolerate food with little odor. For example, they may be able to eatat breakfast, since many breakfast foods have little odor.
The following suggestions can help cancer patients manage anorexia:
Suggestions for helping cancer patients manage taste changes include:
To prevent the development of taste dislikes:
To help dry mouth or trouble swallowing:
The cancer patient should be encouraged to keep a positive attitude towardstreatment and try to take in enough calories and protein. Individual calorieand protein requirements can be calculated so that realistic goals can be setwith the patient and his or her care givers. The actual amount of calories andprotein needed by each cancer patient varies. The following formula can beused to determine how many calories are needed to maintain a cancer patient'sbody weight:
General guidelines of calories required (assuming light activity):
Some cancer patients need more calories and protein. A cancer nutritionist(dietitian, diet technician, nurse, or doctor with special training innutrition) can help determine the nutritional needs and options of eachpatient. General guidelines for grams of protein needed by cancer patients:multiply weight in pounds by 0.5.
Sometimes it may be necessary to maintain nutrition using other methods thaneating. Enteral nutrition (infusions through the intestinal tract, usually thestomach) may be used. The factors that indicate enteral nutrition is neededare:
Enteral nutrition should not be used when the following are present:
Parenteral nutrition (usually an infusion into a vein) should be given for thefollowing reasons:
Parenteral nutrition should not be used when the following are present:
It is believed that cancer patients who have enough nutrition are better ableto stand therapy and its side effects. The type of nutritional support usedshould be chosen based on the patient's physical needs, degree of nutritionalproblem, disease, the amount of time that support will be needed, and theresources available. If the gastrointestinal tract is working and will not beaffected by the cancer therapy, then enteral support is best. Enteralnutrition can be given through a tube in the nose or by tubes placed duringsurgery.
Medications can also be used to improve nutrition. Medications may includethose for pain management, treatment of constipation or diarrhea, stimulationof the stomach, or the use of appetite stimulants.
For more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 9:00 a.m. to 4:30 p.m. Deaf and hard-of-hearing callers with TTY equipment may call 1-800-332-8615. The call is free and a trained Cancer Information Specialist is available to answer your questions.
Web sites and Organizations
The NCI's Cancer.gov Web site provides online access to information on cancer, clinical trials, and other Web sites and organizations that offer support and resources for cancer patients and their families. There are also many other places where people can get materials and information about cancer treatment and services. Local hospitals may have information on local and regional agencies that offer information about finances, getting to and from treatment, receiving care at home, and dealing with problems associated with cancer treatment.
The NCI has booklets and other materials for patients, health professionals, and the public. These publications discuss types of cancer, methods of cancer treatment, coping with cancer, and clinical trials. Some publications provide information on tests for cancer, cancer causes and prevention, cancer statistics, and NCI research activities. NCI materials on these and other topics may be ordered online or printed directly from the NCI Publications Locator. These materials can also be ordered by telephone from the Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237), TTY at 1-800-332-8615.
The NCI's LiveHelp service, a program available on several of the Institute's Web sites, provides Internet users with the ability to chat online with an Information Specialist. The service is available from 9:00 a.m. to 10:00 p.m. Eastern time, Monday through Friday. Information Specialists can help Internet users find information on NCI Web sites and answer questions about cancer.
For more information from the NCI, please write to this address:
PDQ is a comprehensive cancer database available on Cancer.gov.
PDQ is the National Cancer Institute's (NCI's) comprehensive cancer information database. Most of the information contained in PDQ is available online at Cancer.gov, the NCI's Web site. PDQ is provided as a service of the NCI. The NCI is part of the National Institutes of Health, the federal government's focal point for biomedical research.
PDQ contains cancer information summaries.
The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries are available in two versions. The health professional versions provide detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions provide current and accurate cancer information.
The PDQ cancer information summaries are developed by cancer experts and reviewed regularly.
Editorial Boards made up of experts in oncology and related specialties are responsible for writing and maintaining the cancer information summaries. The summaries are reviewed regularly and changes are made as new information becomes available. The date on each summary ("Date Last Modified") indicates the time of the most recent change.
PDQ also contains information on clinical trials.
Some patients have symptoms caused by cancer treatment or by the cancer itself. Patients who have symptoms related to cancer treatment may want to take part in a clinical trial. A clinical trial is a study to answer a scientific question, such as whether one method of treating symptoms is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During supportive care clinical trials, information is collected about new treatment methods, the risks involved, and how well they do or do not work. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard."
Listings of clinical trials are included in PDQ and are available online at Cancer.gov. Descriptions of the trials are available in health professional and patient versions. Many cancer doctors who take part in clinical trials are also listed in PDQ. For more information, call the Cancer Information Service 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615.
Jul 1, 2010 - Immunosuppressive treatment with cyclosporine A, rather than tacrolimus, with dose level monitoring two hours post-dosing or in patients age 50 or younger appears to have a significant association with the development of de novo cancer after liver transplantation, according to research published in the July issue of Liver Transplantation.