A controlled Study of Postoperative Radiotherapy for Patients with Completey Resected Non-Small Cell Lung Carcinoma
Reviewers: John Han-Chih Chang, MD Source: Cancer 1999 Jul 15; Volume 86(Number 2): pages 265 - 273Background/Critique/DiscussionOverall, non-small cell lung cancer (NSCLCa) comprises about 85% of the 171,000 newly diagnosed lung cancers each...
Chemoradiation for Locally Advanced, Unresectable NSCLC-New Standard of Care, Emerging Strategies
Reviewers: Li Liu, MDSource: Oncology, 13:1075-1088, August 1999BackgroundThis comprehensive review of the management of locally advanced unresectable non-small-cell lung cancer (NSCLC) summarizes major landmark studies that have led to the current...
Molecular Pathological Substaging in 244 Stage I Non-Small Cell Lung Cancer Patients: Clinical Implications
Reviewers: John Han-Chih Chang, MD and Kenneth Blank, MD Source: Journal of Clinical Oncology 1998; volume 16 (number 7): pages 2468 ? 2477IntroductionNon-small cell lung cancer is one of the most deadly malignancies secondary to its high...
Multi-Institutional Randomized Phase II Trial of Gefitinib for Previously Treated Patients with Advanced Non-Small Cell Lung Cancer
Authors: Masahiro Fukuoka, Seiji Yano, Giuseppe Giaccone, Tomohide Tamura, Kazuhiko Nakagawa, Jean-Yves Douillard, Yutaka Nishiwaki, Johan Vansteenkiste, Shinzoh Kudoh, Danny Rischin, Richard Eek, Takeshi Horai, Kazumasa Noda, Ichiro Takata, Egbert...
Patterns of Failure after Resection of Non-small-cell lung cancer: Implications for Postoperative Radiation Therapy Volumes
Authors: Kelsey CR, Light KL, Marks LB Reference: Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1097-105 Affiliation: Department of Radiation Oncology, Duke University Medical Center Background Several studies have shown that local...
Phase III Study of Concurrent versus Sequential Thoracic Radiotherapy in Combination with Mitomycin, Vindesine, and Cisplatin in Unresectable Stage III Non-Small-Cell Lung cancer
Reviewers: Li Liu, MDSource: Journal of Clinical Oncology, 17(9): 2692, September 1999BackgroundThis is a long-term follow-up of a landmark study by the West Japan Lung Cancer Group (WJLCG) directly comparing concurrent chemoradiation to sequential...
Postoperative radiotherapy in non-small cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomized controlled trials
Author: PORT Meta-analysis Trialists Group Source:Lancet. 1998 Jul 25;352(9124):257-63 Background Lung cancer remains the leading cause of cancer death in the United States. Surgery is the treatment of choice for non-small cell lung cancer...
Preoperative Chemotherapy Followed by Concurrent Chemoradiation Therapy Based Hyperfractionated Accelerated Radiotherapy and Definitive Surgery in Locally Advanced Non-Small Cell LungCancer: Mature Results of a Phase II Trial
Source Journal of Clinical Oncology 1998; Volume 16 (Number 2): pages 622-634.BackgroundLocally advanced non-small cell lung cancer (NSCLCa) has a very poor prognosis. By the American Joint Committee on Cancer, the stages included in the definition...
Prospective Randomized Trial of Docetaxel Versus Best Supportive Care in Patients With Non?Small-Cell Lung Cancer Previously Treated With Platinum-Based Chemotherapy
Reviewers: Li Liu, MDSource: Journal of Clinical Oncology, Vol 18, Issue 10 (May), 2000: 2095-2103IntroductionLung cancer is the leading cause of death from cancer for both men and women in the United States and accounts for approximately 14% of new...
Radiosensitization with Carboplatin for Patients with Unresectable Stage III Non-Small-Cell Lung Cancer: A phase III Trial of the Cancer and Leukemia Group B and the Eastern Cooperative Oncology Group
Reviewers: John Han-Chih Chang, MDSource: Journal of Clinical Oncology 1999; Volume 17 (Number 1): pages 4 ? 11BackgroundNon-small-cell lung cancer (NSCLCa) is usually best treated with surgery as the mainstay of curative therapy, reserving...
Randomized Phase III Study of Gemcitabine-Cisplatin Versus Etoposide-Cisplatin in the Treatment of Locally Advanced or Metastatic Non-Small-Cell Lung Cancer
Reviewers: John Han-Chih Chang, MDSource: Journal of Clinical Oncology 1999; Volume 17: pages 12 ? 18BackgroundChemotherapy (ChT) for advanced non-small-cell lung cancer (NSCLCa) has been a fairly controversial topic for many years. There have been...
Randomized Phase III Trial of Docetaxel Versus Vinorelbine or Ifosfamide in Patients With Advanced Non?Small-Cell Lung Cancer Previously Treated With Platinum-Containing Chemotherapy Regimens
Source: Journal of Clinical Oncology, Vol 18, Issue 12 (June), 2000: 2354-2362IntroductionNon-small cell lung cancer (NSCLC) is a leading cause of deaths related to cancer. Surgery is the treatment of choice, but only about 20% of tumors are...
Toxicity and Outcome Results of RTOG 93-11: A Phase I-II Dose-Escalation Study Using Three-Dimensional Conformal Radiotherapy in Patients with Inoperable Non-small-cell Lung Carcinoma
Background The RTOG (Radiation Therapy Oncology Group) initiated dose escalation protocol 93-11 for patients with stage I-III lung cancer in order to attempt improvement in local control. Three-dimensional conformal radiotherapy was used to...
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