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Olivotto IA, Ragaz J
Abramson Cancer Center of the University of Pennsylvania
Ultima Vez Modificado: 1 de noviembre del 2001
Reviewers: John Han-Chih Chang, MD
Source: Cancer 1998; Volume 83 (Number 5): pages 948 - 955
Univariate, bivariate and multivariate logistic regression analyseswere performed on all study patients. Clinical factors, such as age atdiagnosis and at menopause, menopausal status, family history ofunilateral, bilateral breast cancer, number of relatives, palpabilityof primary tumor and axillary lymph nodes, were evaluated. Thepathological factors included tumor grade, histological classification,size of primary tumor, estrogen receptor status, margin status,presence or absence of lymph vascular space involvement (LVI) orperi-neural invasion.
Multivariate logistic regression analysis was utilized to constructa model predicting nodal involvement in the entire sample. Initially,a six category model was utilized and is depicted in the Table 3. The"B" value represents difference between the risk of nodal involvement for that category and the average for all categories of that variable (a negative B means a lower than average risk of ALN metastases). The model, the authors contend, correctly predicted the ALN status in 76.63% of thecases. They felt that the model was too cumbersome to be of clinicalsignificance, since there are too many possible combinations for which to account. Thus, they developed a 3 category model utilizingpalpability of primary tumor and ALN=92s, tumor size and presence orabsence of LVI. They found this to be of comparable predictionaccuracy in ALN status (76.56%). Table 5 displays the data and therisk of ALN metastases based on their model. Based on this, theydivided the patients into 4 risk groups for ALN involvement: Very Low[< 10% risk], Low [10-14% risk], Intermediate [15-50% risk] and High[> 50%]. In table 5, very low risk patients hadnonpalpable disease of 5 mm or less without LVI [dashed line outline]. Low risk patients were those that had palpable disease of 6-10 mmor were nonpalpable without LVI [single line outline]. High riskpatients had clinically palpable ALN's or LVI in palpable tumors 2 cmor greater or nonpalpable tumors 3 cm or greater [double line outline]. Intermediate risk patients cover everyone in between.
Table 6 gives the data on the percentage of ALN positivity in eachrisk group. Because of the prognostic implication of greater than 3ALN's involvement for local control, this was also included in thedata presented in that table. Table 7 yields the data on the usage ofany systemic therapy (Tamoxifen/ChT/Both) according to risk groups andALN status. This article details a clinical model proposed by thisCanadian Group to hopefully guide us to an age of non pathologicalstaging for ALN.
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