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OncoLink se complace en ofrecer una amplia lista de lista completa de los agentes quimioterapéuticos más comúnmente usados??. Esta guía de referencia incluye información sobre la forma en que cada fármaco se administra, cómo funcionan, y los pacientes los efectos secundarios comunes pueden experimentar.
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Reviewer: Ryan P. Smith, MD
The Abramson Cancer Center of the University of Pennsylvania
Ultima Vez Modificado: 4 de julio del 2004
Author: Jocham D, et al.
Source: Lancet, 363, Feb 2004, pg 594
Various methods of tumor vaccines have been studied in many different cancers with varying success. Until the time of publication of this trial, the major successes have been with prophylactic vaccinations (specifically against viruses that are implicated in cervical cancer and hepatoma). Perhaps a large reason that treatment vaccines have not found great success is that they are tried as second and third line treatments. They are often given to patients who have very advanced disease and a weakened immune system to react to the vaccine due to the various chemotherapy regimens to which they have been exposed. This trial reports on results of using an autologous vaccine against a patient's own renal cell carcinoma. The results are impressive, as the progression free survival was significantly higher in those patients receiving the vaccine. This is in contrast to other negative studies that had smaller patient populations and a different method of vaccine preparation. Weaknesses of the trial include the fact that they did not verify an immune response using a surrogate marker such as delayed type hypersensitivity reactions. The authors defend this correctly by stating the fact that these reactions are not reliable. The main limitation in the broad acceptance of these results is simply the applicability of the results. A relative minority of patients will have access to large institutions that have the means and technology to produce an individual vaccine such as was administered in this trial. Although this remains a major hurdle to overcome in the field of tumor immunotherapy, these results are impressive and should be considered in a disease that has limited other reliable options in terms of adjuvant therapy.
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