Reviewer: Courtney Bui, MD
Abramson Cancer Center of the University of Pennsylvania
Ultima Vez Modificado: 24 de diciembre del 2006
Birgisson H, Pahlman L, Gunnarsson U, Glimelius B. Journal of Clinical Oncology 23:8697-8705, 2005.
Radiation therapy and/or chemotherapy combined with surgery typically comprise the standard treatment for early to intermediate stage rectal cancer. Pre-operative treatment is often better tolerated than post-operative treatment, and thus is preferred at some centers. The Swedish Rectal Cancer Trial was designed to evaluate the benefit of pre-operative radiation therapy utilizing 5 Gy x 5 to 25 Gy, followed by resection 1 week later. The benefit of radiation therapy has been demonstrated in several trials, including this one, but the therapy is not without risk. This article presents the long-term toxicity data of the previously published Swedish Rectal Cancer Trial.
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