Proving HPV Cause

Ultima Vez Modificado: 5 de febrero del 2010

Share article


Question

Dear OncoLink "Ask The Experts,"

Can HPV be proven as the cause of a non-cervical cancer- if so, how?

Answer

Harry Quon, MD, MS (CRM), Assistant Professor of Radiation Oncology at the Abramson Cancer Center of the University of Pennsylvania, responds:

It comes from many studies of large populations or what we call epidemiologic studies. These show consistent relationships and that the relationships are strong between risk factors that are common to the cervix cancer story such as multiple sexual partners and sexual practice at a young age. There are also studies showing HPV infection in non-cervical cancers. Lastly, there are now clinical studies that have treated oropharynx cancers and have taken tissue samples from the cancer and tested to see if there is evidence of HPV infection in the cancer. Many oropharynx cancers show this. Even more significant is that the results of the treatment, show that oropharynx cancers with HPV do better than non-HPV oropharynx cancers. The story with the HPV associated oropharynx cancers isn't that straight forward as those that also get exposed the adverse effects of tobacco when there is infection with a cancer causing HPV virus behave more aggressively and their results from treatment are in the middle.

This question and answer was part of the OncoLink Brown Bag Chat Series, How Much Do You Know About HPV?. View the entire transcript here.


News
HPV 16 Diagnostic Tests Vary in Accuracy, Prognostic Value

Oct 5, 2011 - Diagnostic tests for human papillomavirus-16 in oropharyngeal squamous cell carcinoma differ in accuracy and prognostic value, with a combination of p16 immunohistochemistry and DNA quantitative polymerase chain reaction proving to be the best discriminator of favorable outcome, according to a study published in the Oct. 1 issue of Clinical Cancer Research.



I Wish You Knew

How an oncology social worker can improve your cancer experience

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Frente a un nuevo diagnóstico de cáncer o de cambiar el curso de su tratamiento actual? Deje que nuestro personal de enfermería cáncer que ayudan a pasar!

Más información