Myeloproliferative disorders

Ultima Vez Modificado: 1 de diciembre del 2002

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Question

Dear OncoLink "Ask The Experts,"
I have a friend who was just diagnosed with MPD. Could you please send me information on what the disorder is exactly? 

Answer

Selina M. Luger, MD, Director of the Leukemia Program and Assistant Professor of Medicine at the University of Pennsylvania, responds:

MPD means myeloproliferative disorder. In these patients, typically there is an increase in the number of cells being made by the bone marrow resulting in increased blood counts. There can be an increase in the white blood cells, hemoglobin, or platelet counts or a combination of these. Sometimes patients will have enlarged spleens. Depending on the specific manifestations of the patient's disorder as well as the results of additional testing that may be done on the blood or bone marrow, the physician will determine how to treat the patient.

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News
STAT3 Mutations ID'd in Rare Lymphoproliferative Disorder

May 18, 2012 - Approximately 40 percent of patients with T-cell large granular lymphocytic leukemia have mutations in the Src homology 2 dimerization and activation domain of the signal transducer and activator of the transcription 3 (STAT3) gene, according to a study published in the May 17 issue of the New England Journal of Medicine.



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