Burning and increased PSA after radical prostatectomy

Alan J. Wein, MD
Ultima Vez Modificado: 1 de enero del 2002

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Question

Dear OncoLink "Ask The Experts,"
My father had radical surgery done for his prostate cancer. Post the surgery, his PSA levels again went up albeit, to 8. Since then however, my father is having a burning sensation when he urinates. Is this normal? What can be causing it? He describes the pain as intense at times.  

Answer

Alan J. Wein, MD, Professor and Chair of the Division of Urology at the University of Pennsylvania School of Medicine, responds:

Following prostatic removal for cancer, the PSA should drop to immeasurable levels and stay there. If your dad's PSA is now 8, this unfortunately signifies that he has recurrent or residual disease. He needs to see his urologist. Here at our institution, we would institute adjunctive treatment. Regarding the burning sensation, this could be due to urinary tract infection or irritation. This is certainly of secondary importance to the issue of the measurable PSA. However, a urine culture should certainly be obtained and any infection that is found should be treated. If he does not have an infection, then there are a number of conditions that can contribute to burning on urination and your local urologist is the individual best equipped to find and treat these. It is doubtful that the burning means anything of a serious nature.

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News
Findings at meeting cover biomarkers for detecting cancer, measuring PSA after prostatectomy

Oct 1, 2010 - A set of biomarkers may accurately detect prostate cancer, and a method for measuring low levels of prostate-specific antigen in men following radical prostatectomy could help guide treatment, according to two studies presented at the American Association for Cancer Research International Conference on Molecular Diagnostics in Cancer Therapeutic Development, held from Sept. 27 to 30 in Denver.



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