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A Phase III Randomized Trial of Intermittent vs. Continuous Androgen Suppression for PSA Progression after Radical Therapy (NCIC CTG PR.7/SWOG JPR.7/CTSU JPR.7/ UK Intercontinental Trial CRUKE/01/013) Presenting Author: J. M. Crook Affiliation: University of British Columbia, Kelowna, BC, Canada, Background Conventional radiotherapy is associated with up to a 30% biochemical failure rate at 5 years. Biochemical failure after either...
Accord12/0405-prodige 2 Phase III Trial Neoadjuvant Treatment In Rectal Cancer. Results After 3 Years Of Follow-up Presenting Author: J. Gerard Affiliation: Centre Antoine-Lacassagne, Nice 06189 Cedex 2, France Background The current standard of care for locally advanced rectal cancer is preoperative chemoradiation followed by surgical resection via...
Cardiovascular Mortality following Short-term Androgen Deprivation in Clinically Localized Prostate Cancer: An Analysis of RTOG 94-08 Presenter: Jason Efstathiou Presenter's Affiliation: Massachusetts General Hospital, Boston, MA Background Androgen deprivation therapy (ADT) has been shown to increase risk for metabolic syndrome, cardiovascular disease (CVD) up to 16% and...
Comparative Long-term Morbidity of Intensity Modulated vs Conformal Radiation Therapy (RT) for Prostate Cancer: A SEER-Medicare Analysis Presenter: N. Sheets Presenter's Affiliation: University of North Carolina, Chapel Hill, NC Background There is a rapid uptake of intensity modulated radiation therapy (IMRT) for treatment of prostate cancer because of potential reduction of...
Comparison Of Intensity Modulated Proton Therapy (IMPT) To Passively Scattered Proton Therapy (PSPT) In The Treatment of Prostate Cancer Presenting Author: S. Choi Presenter's Affiliation: M.D. Anderson Cancer Center, Houston, TX Background Prostate cancer can be definitively treated with radiotherapy. Higher doses of radiotherapy have been shown to improve biochemical...
Electronic Web-Based Technology Significantly Improves Quality of Life (QOL) Data Collection: Analysis of RTOG 0828 Presenter: Benjamin Movsas, MD Presenter's Affiliation: Henry Ford Hospital, Detroit, MI Background Missing data are a significant problem in clinical trials, particularly for QOL, which cannot be obtained retrospectively. Unlike...
FDG Uptake Predicts Recurrence and Survival in Patients with Unresectable Stage III Non-Small Cell Lung Cancer treated with 74 Gy (RBE) Proton Therapy and Chemotherapy Presenting Author: J. Chang Institution: M.D. Anderson Cancer Center, HOUSTON, TX Background Concurrent chemoradiation is the standard of care for locally advanced, unresectable non-small cell lung cancer (Curran et al., RTOG 9410, JNCI,...
Five Year Results of a Randomized External Beam Radiotherapy Hypofractionation Trial for Prostate Cancer Presenter: Alan Pollack, MD Presenter's Affiliation: Fox Chase Cancer Center/ University of Miami Background Dose escalation has been shown in a number of prospective randomized trials to improved biochemical recurrence free survival for...
High-dose Proton-beam Based Radiation Therapy with or without Surgery in the Management of Primary and Recurrent Spine Chordomas: A Retrospective Review of Outcomes and Clinicopathologic Prognostic Factors Presenter: Ronny Rotundo, MD Presenter's Affiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA Background Chordomas are rare, slow-growing, low metastatic potential, but locally...
Is Androgen Deprivation Therapy Necessary in Intermediate Risk Prostate Cancer Patients Treated in the Dose escalation Era? Presenter: K.O. Castle Presenter Affiliation: MD Anderson Cancer Center, Houston, TX Background Studies have shown androgen deprivation therapy (ADT) to increase over all survival (OS) in intermediate and high risk prostate cancer patients...
Long Term Follow-up After Charged Particle Therapy for Chordomas and Chondrosarcomas of the Head and Neck: the Lawrence Berkeley National Laboratory (LBNL) / University of California San Francisco (UCSF) Experience Presenting Author: K.K. Mishra Presenter's Affiliation: University of California San Francisco, San Francisco, CA Background TheLawrence Berkeley National Laboratory (LBNL) performed helium and heavier charged particle radiotherapy jointly...
Long Term Outcomes Comparing Three-Dimensional Conformal Radiation Therapy to Intensity Modulated Radiation Therapy with Concurrent Chemotherapy for the Treatment of Esophageal Cancer: The MD Anderson Experience Presenter: BA Myles Presenter Affiliation: MD Anderson Cancer Center, Houston, TX Background 3D-CRT with concurrent chemotherapy (pre-operative or definitive) is the standard of care for treating patients with esophageal cancer. However,...
Long-term Cause-specific Mortality Of Adolescent And Young Adult (AYA) Survivors Of Bone And Soft Tissue Sarcoma (STS): A Population-based Study Presenting Author: P. Youn Presenter's Affiliation: Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY Background Combined modality therapy has improved outcomes in the treatment of bone...
Long-term Morbidity of Intensity Modulated vs Conformal Radiation Therapy (RT) for Prostate Cancer: A SEER-Medicare Analysis Presenter: N. Sheets Presenter's Affiliation: University of North Carolina, Chapel Hill, NC Background There is a rapid uptake of intensity modulated radiation therapy (IMRT) for treatment of prostate cancer because of potential reduction of...
Long-term Update of U.S. GI Intergroup RTOG 98-11 Phase III Trial for Anal Carcinoma: Concurrent Chemoradiation with 5FU-Mitomycin Yields Better Disease-Free and Overall Survival than 5FU-Cisplatin Presenting Author: Leonard Gunderson Background Randomized studies has shown definitive chemotherapy and radiation render a high local control and colostomy free survival (CFS) for patients with anal cancer (EORTC, Bartelink JCO 1997)....
Meta-analysis of the Impact of Androgen Deprivation Therapy on Cardiovascular Death in Patients with Prostate Cancer Presenter: Paul Nguyen, MD Presenter's Affiliation: Dana Farber/ Brigham and Women's Cancer Center Background Although ADT has been shown in prospective, randomized trials to improve prostate cancer mortality in high risk localized,...
Multi-Institutional Prospective Evaluation of Bowel Quality of Life After Prostate External Beam Radiation Therapy Identifies Patient and Treatment Factors Associated with Patient Reported Outcomes Presenter: D.A. Hamstra Presenter Affiliation: University of Michigan, Ann Arbor, MI Background There are limited tools to evaluate quality of life, especially related to bowel toxicity, in prostate cancer patients undergoing radiation...
Music Relaxation Video and Pain Control: A Randomized Controlled Trial for Women Receiving Intracavitary Brachytherapy for Gynecological Cancer Presenting Author: G.C. Chi Institution: Texas Christian University, Fort Worth, Texas Background Intracavitary brachytherapy is used along with external beam radiotherapy for the treatment of gynecologic malignancies including cervical and...
Preliminary Analysis of 3DCRT vs IMRT on the High Dose Arm of the RTOG 0126 Prostate Cancer Trial: Toxicity Report Presenter: Jeff Michalski , MD Presenter's Affiliation: Washington University Medical Center, St. Louis, MO Trial was funded by the NCI and run by RTOG. Background Numerous dosimetric and several single institution retrospective studies...
Prospective Randomized Trial Comparing External Beam Radiotherapy versus Watchful Waiting in Early Prostate Cancer (T1b-T2, pN0, Grade 1-2, M0) Presenting Author: A. Widmark Affiliation: Department of Radiation Sciences, Oncology, Umeå University, Umeo, Sweden Background In the mid-eighties, watchful waiting was an acceptable standard of care but radical prostatectomy and definitive...
Proton Beam Therapy for Patients with Malignancies of The Nasal Cavity, Para-nasal Sinuses, and/or Involving the Skull Base: The Analysis of Late Toxicity Presenting Author: S. Zenda Presenter's Affiliation: National Cancer Center Hospital East, Chiba, Japan Background Proton beam radiotherapy (PBT), with its characteristic spread out Bragg peak (SOBP), permits sharp fall off distally and...
Randomized Phase III Comparison of Standard Dose (60Gy) Versus High-Dose (74Gy) Conformal Chemoradiotherapy +/- Cetuximab for Stage IIIA/B Non-Small Cell Lung Cancer: Preliminary Findings on Radiation Dose in RTOG 0617 Presenter: Jeffrey Bradley, MD Background Dose escalation has been a controversial topic in definitive treatment of non-small cell lung cancer (NSCLC) with previous studies showing only 20% pathological complete response with 60 Gy and...
Results from a Prospective Trial of Proton Radiotherapy for Medulloblastoma: Clinical Outcomes including Hearing and Neurocognitive Presenter: Torunn Yock, MD Presenter's Affiliation: Massachusetts General Hospital, Boston, MA Background Medulloblastoma is a type of brain tumor that occurs in infants and young children, and this type of brain tumor represents...
Trends in Radiation Oncology Services in the IMRT Era: Evolving Patterns of Usage and Payments in Medicare Patients From 2000-2009 Presenter: X Shen Presenter Institution: Thomas Jefferson University, Philadelphia, PA Background Use of IMRT has rapidly increased over the last decade for treatment of various cancers such as prostate and head and neck. Also, there as has...