Impact of a boost dose of 16 Gy on the local control and cosmesis in patients with early breast cancer: The EORTC boost versus no boost trial

Li Liu, MD
OncoLink Assistant Editor
Ultima Vez Modificado: 23 de octubre del 2000

Share article


Presenter: H. Bartelink
Affiliation: The Netherlands Cancer Institute


Summary:

Breast conservation therapy (BCT) is a standard of care in the management of patients with early stage breast cancers. BCT results have consistently shown survival equivalence to mastectomy. However, the question remains whether boost is necessary for local tumor control and what its impact is on cosmesis as part of a breast conserving therapy is still unknown. In this study, researchers at the European Organization for Research and Treatment of Cancer (EORTC) reported a phase III randomized trial evaluating the impact of a boost dose of 16 Gy on outcome of patients with early stage breast cancers.


Methods:

  • In this phase III study, a total of 5318 patients with early stage breast cancers who underwent a microscopically complete excision were randomized between no boost or a 16 Gy boost following whole breast irradiation of 50 Gy.
  • Median follow-up was 5.1 years.


Results:

  • For all patients as a whole, younger age (< 40 years) was the single most significant predictor for local recurrence in the multivariate analysis.

  • 5-year actuarial local recurrence rate was 6.8% in the no boost group as compared to 4.3% in the boost group (p<0.0001), favoring the boost group.

  • There was no survival difference between the two groups.

  • Cosmetic results appeared to be better in the no boost group, but the difference was not statistically significant.


Author's Conclusions:

  • 16 Gy boost reduced the local recurrence by 41% (4.3% vs. 6.8%).

  • 16 Gy boost resulted in a slight reduction of cosmetic outcome that was not statistically significant.

  • With a median follow-up of 5.1 years, there was no difference in survival between the boost and the no boost group.

  • Longer follow-up is needed to draw any definitive conclusions.


News
No Benefit of Induction Chemo, High-Dose Boost in Anal Cancer

Apr 26, 2012 - Neither induction chemotherapy nor high-dose radiation boost is associated with an improvement in five-year colostomy-free survival in patients with locally advanced anal canal carcinoma, according to a study published online April 23 in the Journal of Clinical Oncology.



I Wish You Knew

How cancer patients have changed my life

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Frente a un nuevo diagnóstico de cáncer o de cambiar el curso de su tratamiento actual? Deje que nuestro personal de enfermería cáncer que ayudan a pasar!

Más información