Higher Doses of Paclitaxel Fail to Improve Survival Rates in Women with Metastatic Breast Cancer

University of Pennsylvania Cancer Center
Ultima Vez Modificado: 18 de mayo del 1998

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Each year approximately 45,000 women in the U.S. are diagnosed with metastatic breast cancer. New research demonstrates that higher doses of Paclitaxel (Taxol) are not necessarily more effective in patients with advanced breast cancers, and that patients can be spared the increased toxicities associated with high doses.

This study of 475 women with metastatic breast cancer found that higher-than-standard doses of Paclitaxel, one of the standard therapies for treating women with advanced breast cancer, does not improve survival, and that the drug's efficacy actually declined at higher doses (28% tumor response rate at a moderate dose, but only 22% at a higher dose). This finding is particularly relevant given the trend in recent years to increase the dose of chemotherapy agents with the presumption that they will be more active, a hypothesis that had not yet been fully tested.

[ Original Abstract ]


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ASCO: Fewer Side Effects With Weekly Paclitaxel in Breast CA

Jun 4, 2013 - For women with breast cancer, low-dose weekly paclitaxel is as effective as the standard-dose regimen given every two weeks, with fewer side effects; and axillary radiotherapy may be better than axillary lymph node dissection in the case of positive sentinel lymph node biopsy, according to two studies presented at the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.



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