Sequential Couplets of Cisplatin/Topotecan and Cisplatin/Paclitaxel as First-Line Therapy in Advanced Epithelial Ovarian Cancer

University of Pennsylvania Cancer Center
Ultima Vez Modificado: 16 de mayo del 1999

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Dr. P. Hoskins presented a Phase II trial of sequential couplets of cisplatin (DDP) and topotecan (TOP) and cisplatin and paclitaxel (T) as first-line therapy for advanced epithelial ovarian cancer on behalf of the National Cancer Institute of Canada. The dosage used were as follows:

DDP/TOP cycles: DDP 50 mg/m2 and TOP 0.75 mg/m2

DDP/T cycles: DDP 75 mg/m2 and T 135 mg/m2 IV infusion over 24 hours

Interval debulking was allowed.

Dr. Hoskins reported that:

  • Dose reduction was needed in 13% of DDP/TOP cycles

  • Dose delays were incurred in 9% of DDP/TOP cycles

  • A response rate of 85%
Dr. Hoskins concluded that:
  • Myelotoxcity of this couplet regimen is high but does not prevent delivery.

  • The response rate is encouraging being that these were predominately suboptimal patients.
This presentation was discussed by David Spriggs, M.D. from Memorial Sloan-Kettering Cancer Center. Dr. Spriggs had reservations:
  • Cisplatin was used instead of carboplatin

  • Marked reduction in topotecan dosing

  • Treatment delay was common

  • Substantial toxicity

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News
ASCO: Pazopanib Ups Survival in Advanced Ovarian Cancer

Jun 4, 2013 - For women with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who have undergone surgery and first-line chemotherapy, maintenance therapy with pazopanib is associated with significant longer median progression-free survival versus placebo, according to a study presented at the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.



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