Carolyn Vachani, RN, MSN, AOCN
Abramson Cancer Center of the University of Pennsylvania
Ultima Vez Modificado: 5 de junio del 2006
Clear cell sarcoma of the kidney was first described in the 1970's and has a tendency to metastasize to the bone and can relapse long after treatment. The Wilm's Tumor Study has been looking at various combinations of chemotherapy to treat this tumor type over the years. The latest study, NWTS-5, looked at alternating cyclophosphamide and etoposide with the current standard of vincristine/doxorubicin/cyclophosphamide. Patients were also treated with radiation.
Median follow-up at the time of this analysis was 4.6 years. Five year event-free survival (no relapses) was 78.9% and 5-year overall survival (survival with or without relapse) was 88.7%. These results were not different from the NWTS-4 treatment plan, so the addition of cyclophosphamide and etoposide had no effect on outcomes. Etoposide is known to cause secondary cancers down the line, so the authors suggest it would be best to not use this combination given the lack of improvement in outcomes. Further planned studies will look at the addition of carboplatin to the NWTS-4 regimen.
Sep 23, 2014 - Patients with microsatellite instable colorectal cancer may respond to treatment with the investigational drug olaparib, which can block a DNA repair pathway in the cancer cells, resulting in accumulated DNA damage and tumor death, according to a briefing presented Nov. 18 at the American Association for Cancer Research -- National Cancer Institute -- European Organisation for Research and Treatment of Cancer International Conference, "Molecular Targets and Cancer Therapeutics," held from Nov. 15 to 19 in Boston.
Sep 23, 2014