Información sobre riesgo, prevención, detección, síntomas, diagnosis, tratamiento y apoyo para el cáncer.
Información sobre el tratamiento del cáncer incluyendo quirúrgica, quimioterapia, radioterapia, estudios clínicos, terapia con protón, medicina complementaria avanzadas.
OncoLink se complace en ofrecer una amplia lista de lista completa de los agentes quimioterapéuticos más comúnmente usados??. Esta guía de referencia incluye información sobre la forma en que cada fármaco se administra, cómo funcionan, y los pacientes los efectos secundarios comunes pueden experimentar.
Maneras que los pacientes de cáncer y las personas que le cuidan puedan enfrentar el cáncer, los efectos secundarios, nutrición, cuestiones en general sobre el apoyo para el cáncer, duelo/decisiones sobre el termino de vida, y experiencias compartidas por sobrevivientes.
Ryan Smith, MD
Abramson Cancer Center of the University of Pennsylvania
Ultima Vez Modificado: 12 de noviembre del 2003
Faculty Disclosure: Peter J. O'Dwyer, M.D.
This presentation by Dr. O'Dwyer contains a discussion on the use of PTK 787/ZK 222584 for the treatment of colorectal cancer which has not been approved by the FDA.
Presenter: Peter J. O'Dwyer, M.D.
Affiliation: University of Pennsylvania
PTK 787 is a selective inhibitor of all three types of the VEGF receptors. It has been shown to reduce the number of tumor microvessels with resultant dilation of the remaining vessels. It has also been shown to inhibit VEGF receptors and has been effective in animal tumor models. In addition, dynamic contrast-enhanced MRI (DCE-MRI) and PET imaging have shown a reduction in blood flow to tumors after the administration of PTK 787.
PTK 787 has been tested in a phase I study in 35 patients with previously untreated metastatic colorectal (CR) cancer. Escalating doses of PTK 787 were combined with FOLFOX4 chemotherapy. In the 28 patients available for response, there was a response rate of 54% and an additional 29% with stable disease. Median time to progression was an impressive 11 months with a median overall survival of 16 months. More importantly in the phase I setting, toxicity profiles were very similar to treatment with FOLFOX4 alone.
This has led to the planning of two phase III studies using PTK 787 at a dose of 1250 mg per day. One is for patients with previously untreated metastatic CR cancer, randomizing between FOLFOX4 + PTK 787 vs. FOLFOX4 alone. The other study has the same design, for patients who have failed 5FU based chemotherapy.
In summary, PTK 787/ZK 222584 is a novel angiogenesis inhibitor, blocking all three VEGF receptors. Its once per day oral dosing is convenient with demonstrated inhibition of angiogenesis as measured by many means, including DCE-MRI and PET imaging. It is well-tolerated with phase I data showing response rates and low toxicity. As the side effects were similar to FOLFOX4 alone with a long time to progression, the phase III study should be supported in hopes of increasing the efficacy of the treatment of metastatic CR cancer.
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