Long Term Follow Up of a Phase II study of Rituximab in Combination with CHOP Chemotherapy in Patients with Previously Untreated Aggressive Non-Hodgkins Lymphoma (NHL)

Reviewer: Julie Draznin Maltzman, MD
OncoLink
Ultima Vez Modificado: 7 de diciembre del 2002

Share article


Presenter: J.M. Vose
Presenter's Affiliation: University of Nebraska Medical Center
Type of Session: Poster

Background

  • Standard therapy for NHL is combination chemotherapy with CHOP (cyclophosphamide/doxorubicin/vincristine/prednisone)
  • Rituxan, a mouse/human anti CD 20 antibody has a distinct mechanism of action and is synergistic with CHOP chemotherapy.
  • This rational is what led to the phase II study that evaluated CHOP/rituxan in previously untreated pts with aggressive NHL. 94% of the pts in that trial had a response. 61% achieved a complete response. At the time the median follow up time was 26 months.
  • This abstract gives long term follow up -- median of 62 months -- of this original phase II trial.

Materials and Methods

  • All pts were treated with 6 cycles of Rituxan 375mg/m2 day 1 and CHOP chemotherapy.
  • 33 pts were enrolled in the trial.
  • Median age =52. 73% of the pts had stage III/IV disease.
  • Disease types included follicular large cell, diffuse large cell, and immunoblastic.

Results

  • At median 62 month follow up , 88% of the pts remained alive and 82% remained free of disease progression.
  • Overall survival curve by Kaplan Meier analysis at 60 months is 87%, with a progression free survival of 80%.
  • Since the first analysis at 26 months, one pt progressed and one pt died of second malignancy (NSCLCa) without progression of NHL.
  • During the entire follow up period 2/23 patients >60 years of age have failed with one death. Similarly, 4/10 pts >60 years of age have failed with 3 deaths.
  • No additional long term complications of CHOP/Rituxan have been reported.

Author's Conclusions

  • Long term results of this phase II trial show that this regimen is safe and active as front line therapy for aggressive NHL. This therapy produces durable response rates for many patients.

Clinical/Scientific Implications

  • This trial certainly expands our armementarium for fighting aggressive lymphomas.
  • Higher response rates, with no additional toxicities, can be achieved by combination chemotherapy and Rituxan in NHL.

Oncolink's ASH Coverage made possible by an unrestricted Educational Grant from Ortho Biotech.


News
Standard-dose rituximab with low-dose CHOP chemotherapy effective for large B-cell lymphoma

Apr 11, 2011 - A standard dose of rituximab combined with a low dose of CHOP (doxorubicin, cyclophosphamide, vincristine, and prednisone) chemotherapy in elderly patients with diffuse large B-cell lymphoma offers good efficacy with acceptable levels of toxicity, according to a study published online April 8 in The Lancet Oncology.



I Wish You Knew

How cancer patients have changed my life

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Frente a un nuevo diagnóstico de cáncer o de cambiar el curso de su tratamiento actual? Deje que nuestro personal de enfermería cáncer que ayudan a pasar!

Más información