The Importance of Head and Neck Lymphoscintigraphy in the Determination of Planning Target Volume for Radiation Therapy of Cephalo-Cervical and Aerodigestive Tumors
Reviewer: William Levin, MD
Ultima Vez Modificado: 6 de octubre del 2002
Presenter: F. Campostrini1 Presenter's Affiliation: Department of Radiation Oncology, ASL 21, Legnago, IT Type of Session: Scientific Background Cancers of the head and neck region commonly spread throughout the body via the lymphatic system.
Radiation therapy can be employed to treat such cancers.
Radiation, when used, is typically given to the region of the primary tumor as well as to the neck, where lymph nodes are located.
Lymphoscintigraphy(LS) is a nuclear medicine technique allowing for visualization of lymph nodes.
The current study looks at the use of LS in regards to it's ablity to help locate neck lymph nodes in patients receiving radiation therapy. Materials and Methods 28 patients with clinically negative lymph nodes were enrolled on this study.
The majority of patients had cancers of the oropharynx, larynx, or oral cavity.
Standard simulation was performed by 3 radiotherapists, at which time the planning treatment volume(PTV) was identified.
Technetium-99 nanocolloids were then injected at four sites (two frontal and two occipital) on the patients' scalp to identify the lymphatic drainage of the neck.
3 hours later, a gammacamera was used to obtain images in the anterior and lateral positions.
The radiotherapists then reviewed the PTV's in relation to the LS images.
Results LS caused no significant patient discomfort, nor was it related with any significant side-effects.
Information gained by LS resulted in 70% of the original treatment plans being altered. Author's Conclusions LS is a safe and effective method of identifying the lymph nodes treated in head and neck cancers.
LS allows for more accurate design of radiation treatment fields and potentially, better results.
By more precisely identifying treatment fields it is posssible to exclude uninvolved critical structures such as the spinal cord. Clinical/Scientific Implications LS is a potentially valuable tool for determining radition treatment volumes in head and neck cancer patients.
It is likely, however, that this technique is highly operator dependent, and has a learning curve.
Therefore, clinician experience with this technique is required to ensure accuracy.
Oncolink's ASTRO Coverage made possible by an unrestricted Educational Grant from Ortho Biotech. English
AACR: New Drug May Add to Therapy for Head and Neck CA
Sep 19, 2014 - The investigational drug alpelisib (previously known as BYL719) appears to inhibit activation of the pathway that leads to resistance to cetuximab, an anti-epidermal growth factor receptor agent used in the treatment of head and neck cancer. These findings were presented at the American Association for Cancer Research's special conference "Targeting the PI3K-mTOR Network in Cancer," held from Sept. 14 to 17 in Philadelphia.
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