Información sobre riesgo, prevención, detección, síntomas, diagnosis, tratamiento y apoyo para el cáncer.
Información sobre el tratamiento del cáncer incluyendo quirúrgica, quimioterapia, radioterapia, estudios clínicos, terapia con protón, medicina complementaria avanzadas.
OncoLink se complace en ofrecer una amplia lista de lista completa de los agentes quimioterapéuticos más comúnmente usados??. Esta guía de referencia incluye información sobre la forma en que cada fármaco se administra, cómo funcionan, y los pacientes los efectos secundarios comunes pueden experimentar.
Maneras que los pacientes de cáncer y las personas que le cuidan puedan enfrentar el cáncer, los efectos secundarios, nutrición, cuestiones en general sobre el apoyo para el cáncer, duelo/decisiones sobre el termino de vida, y experiencias compartidas por sobrevivientes.
Reviewer: Neha Vapiwala, MD
Abramson Cancer Center of the University of Pennsylvania
Ultima Vez Modificado: 5 de junio del 2004
This study discusses an off-label use of rituximab for the treatment of NHL.Presenter: M. G. Pfreundschuh
Non-Hodgkin's lymphoma (NHL) is the fifth most common malignancy in the United States, with over 50,000 cases diagnosed yearly. The majority of these cases occur in adults, with an average age at diagnosis of 60 years. The era of molecular anti-cancer therapy has ushered in a variety of targetted agents employed in conjunction with more standard NHL treatment such as chemotherapy. Rituximab was the first monoclonal antibody approved by the US FDA for anti-cancer therapy. It is specifically approved for the treatment of relapsed or refractory low-grade or follicular, CD20+, B-cell non-Hodgkin's lymphoma. It has been or is being extensively studied in over 200 clinical trials, and is well established in the treatment of older NHL patients. The data are not as robust in its use for younger, low-risk NHL patients, and thus the authors designed this trial to specifically evaluate its possible benefit in this specific group.
Materials and Methods
The results of this study are very promising in the management of young, low-risk DLBCL patients. The addition of rituximab to standard chemotherapy regimens appears to improve the outcome in terms of time to treatment failure, disease progression, and overall survival. Furthermore, these improvements are achieved without an undesirable increase in adverse effects. This supports the already well-established role of rituximab by demonstrating its benefit in a relatively low-risk group compared to the elderly patient cohorts in whom it has traditionally been applied.
However, while these data are very encouraging, it is important to remember that this is an interim analysis of a smaller subset of the overall patient group. In order to make a truly comprehensive and meaningful analysis, a final intention-to-treat analysis for the entire group will be needed . Also, it is important to note that this study did exclude the MOST low-risk patients of all, those with stage I, non-bulky disease. It remains to be seen if this subgroup would also benefit from the addition of rituximab, and future studies are likely to address this.
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