Presenter: T. Dipetrillo Presenter's Affiliation: Brown University
Type of Session: Scientific
Locally advanced pancreatic cancer has <5% 5 year survival despite advances in chemotherapy and radiation advances
Gemcitabine and paclitaxel are both radiation sensitizers
The use of paclitaxel has demonstrated efficacy in RTOG 98-12
The feasibility of concurrent weekly paclitaxel and gemcitabine with radiation is investigated in this phase I study
This is a Phase I prospective trial of 20 patients. Sixteen were deemed unresectable by CT +/- ultrasound (via major vessel invasion or extensive adenopathy) and 4 patients had underwent partial resection and had residual disease.
Radiation was delivered at 1.8 Gy/fraction to a dose of 45 Gy to the primary tumor plus regional nodes. Conedown to the primary tumor for an additional 5.4 Gy.
Paclitaxel (40 mg/m2) was delivered weekly
Gemcitabine was given in a dose escalating form: Level I-75 mg/m2/week, Level II-150 mg/m2/week, Level III-110 mg/m2/week)
Dose limiting Toxicity (DLT) was Grade 4 hematologic toxicity or Grade 3 nonhematologic toxicity
Three patients were initially treated with Level I dose (75 mg/m2/wk) with no DLT
Three patients were treated with Level II dose (150 mg/m2/wk), all 3 of which had DLT (GI).
Five patients were treated with Level III dose (110 mg/m2/wk), 3 of which had GI DLT.
Maximally tolerated dose was deemed as 75 mg/m2/wk, and an additonal 8 patients were treated with this dose level. 2/11 had Grade 3/4 toxicity (anorexia/dehydration)
Ten/11 were radiographically evaluable, 4 of which had a PR. These 4 patients had surgery, one of which had a pathological CR. This patient continues to be NED 21 months after surgery.
The maximally tolerated dose was weekly paclitaxel 40 mg/m2/wk, gemcitabine 75 mg/m2/wk and radiation to 50.4 Gy.
Substantial activity was seen with gemcitabine
Enrollment was encouraged into RTOG PA-0020 (paclitaxel, gemcitabine, FTI, radiation to 50.4 Gy)
Clinical/Scientific Implications Pancreatic cancer has a poor prognosis with standard 5-FU chemotherapy concurrent with radiation. Gemcitabine and paclitaxel have been shown to have significant activity in pancreatic cancer, but (especially gemcitabine) can elicit extensive radiation toxicity. This phase I trial demonstrates the maximally tolerated dose of gemcitabine, allowing further studies to be done. Given that pancreatic cancer has a dismal prognosis with traditional therapies, enrollment onto these studies should be encouraged.
Oncolink's ASTRO Coverage made possible by an unrestricted Educational Grant from Bristol-Myers Squibb Oncology and Pharmacia Oncology.
Oct 18, 2013 - For patients with metastatic pancreatic cancer, treatment with albumin-bound paclitaxel plus gemcitabine is more effective than gemcitabine alone, according to a study published online Oct. 16 in the New England Journal of Medicine.